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ClinicalTrials.gov 8 recruiting now official registry

Unresectable Malignant Solid Neoplasm clinical trials

Every US clinical trial registered for Unresectable Malignant Solid Neoplasm — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

21 US clinical trials · 8 currently recruiting

The research picture

Unresectable Malignant Solid Neoplasm has 21 registered US clinical trials, 8 of them open to new participants right now — about 38% of the total.

8
recruiting participants now
38%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
18
top sponsor: National Cancer Institute (NCI)

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING Phase 2 88 participants

Testing the Combination of the Anti-cancer Drugs ZEN003694 (ZEN-3694) and Talazoparib in Patients With Advanced Solid Tumors, The ComBET Trial

National Cancer Institute (NCI)

NCT05327010

RECRUITING Phase 1 66 participants

Testing the Combination of Two Anti-cancer Drugs, Peposertib (M3814) and Tuvusertib (M1774) for Advanced Solid Tumors

National Cancer Institute (NCI)

NCT05687136

RECRUITING Phase 1 55 participants

Testing the Combination of DS-8201a and Olaparib in HER2-Expressing Cancers With Expansion in Patients With Platinum Resistant Ovarian Cancer

National Cancer Institute (NCI)

NCT04585958

RECRUITING Phase 1 52 participants

TR-002 for the Treatment of Advanced, Unresectable or Metastatic Solid Tumors and Unresectable or Metastatic, Refractory Pancreatic Adenocarcinoma

University of California, Davis

NCT07189195

RECRUITING Phase 1 45 participants

Testing the Safety and Efficacy of the Combination of Two Anti-cancer Drugs, ZEN003694 and Abemaciclib, for Adult and Pediatric Patients (12-17 Years) With Metastatic or Unresectable NUT Carcinoma, Breast Cancer and Other Solid Tumors

National Cancer Institute (NCI)

NCT05372640

RECRUITING Phase 1 43 participants

Studying the Safety and Determining the Optimal Dose of Novobiocin in Patients With Tumors That Have Alterations in DNA Repair Genes

National Cancer Institute (NCI)

NCT05687110

RECRUITING Phase 1 42 participants

MTI-301 for the Treatment of Metastatic or Unresectable and Refractory Solid Cancers

Mayo Clinic

NCT06911008

RECRUITING Phase 1 30 participants

Testing the Addition of an Anti-Cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment (Capecitabine) for Metastatic or Unresectable Cancers

National Cancer Institute (NCI)

NCT05803382

ACTIVE NOT RECRUITING Phase 1 103 participants

Testing the Combination of New Anti-cancer Drug Peposertib With Avelumab and Radiation Therapy for Advanced/Metastatic Solid Tumors and Hepatobiliary Malignancies

National Cancer Institute (NCI)

NCT04068194

ACTIVE NOT RECRUITING Phase 1 96 participants

Trametinib and Navitoclax in Treating Patients With Advanced or Metastatic Solid Tumors

National Cancer Institute (NCI)

NCT02079740

ACTIVE NOT RECRUITING Phase 1 64 participants

Testing the Combination of Copanlisib, Nivolumab and Ipilimumab in Patients With Advanced Cancer and Lymphoma

National Cancer Institute (NCI)

NCT03502733

ACTIVE NOT RECRUITING Phase 1 62 participants

Testing the Biological Effects of DS-8201a on Patients With Advanced Cancer

National Cancer Institute (NCI)

NCT04294628

ACTIVE NOT RECRUITING Phase 1 54 participants

Testing the Addition of an Anti-cancer Drug, Copanlisib, to the Usual Immunotherapy (Nivolumab With or Without Ipilimumab) in Patients With Advanced Solid Cancers That Have Changes in the Following Genes: PIK3CA and PTEN

National Cancer Institute (NCI)

NCT04317105

ACTIVE NOT RECRUITING Phase 2 54 participants

Testing Whether Cancers With Specific Mutations Respond Better to Glutaminase Inhibitor, Telaglenastat Hydrochloride, Anti-Cancer Treatment, BeGIN Study

National Cancer Institute (NCI)

NCT03872427

ACTIVE NOT RECRUITING Phase 1 40 participants

Atezolizumab in Treating Patients With Cancer Following Adoptive Cell Transfer

National Cancer Institute (NCI)

NCT02862275

ACTIVE NOT RECRUITING Phase 1 39 participants

Testing the Combination of the Anti-cancer Drugs Copanlisib, Olaparib, and MEDI4736 (Durvalumab) in Patients With Advanced Solid Tumors With Selected Mutations

National Cancer Institute (NCI)

NCT03842228

ACTIVE NOT RECRUITING Phase 1 36 participants

Pembrolizumab and Recombinant Interleukin-12 in Treating Patients With Solid Tumors

National Cancer Institute (NCI)

NCT03030378

ACTIVE NOT RECRUITING Phase 1 28 participants

Testing the Addition of an Anti-cancer Drug, BAY 1895344, to Usual Chemotherapy for Advanced Stage Solid Tumors, With a Specific Focus on Patients With Small Cell Lung Cancer, Poorly Differentiated Neuroendocrine Cancer, and Pancreatic Cancer

National Cancer Institute (NCI)

NCT04514497

ACTIVE NOT RECRUITING Phase 1 23 participants

Avelumab and M6620 for the Treatment of DDR Deficient Metastatic or Unresectable Solid Tumors

M.D. Anderson Cancer Center

NCT04266912

ACTIVE NOT RECRUITING Phase 1 19 participants

Cediranib Maleate and Selumetinib Sulfate in Treating Patients With Solid Malignancies

National Cancer Institute (NCI)

NCT01364051

ACTIVE NOT RECRUITING Phase 1 13 participants

Testing the Sequential Combination of the Anti-cancer Drugs Olaparib Followed by Adavosertib (AZD1775) in Patients With Advanced Solid Tumors With Selected Mutations and PARP Resistance, STAR Study

National Cancer Institute (NCI)

NCT04197713

Phase Distribution

PhaseTrial count
Phase 1 19
Phase 2 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Unresectable Malignant Solid Neoplasm Trial Landscape

ClinicalTrials.gov lists 21 US studies indexed under Unresectable Malignant Solid Neoplasm, and 8 of those are currently open to recruitment — roughly 38% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Unresectable Malignant Solid Neoplasm shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 21 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Unresectable Malignant Solid Neoplasm is led by National Cancer Institute (NCI) with 18 indexed trials, alongside 3 other organizations in the top contributor list. The list on this page surfaces up to 21 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Unresectable Malignant Solid Neoplasm?

PlainTrial tracks 21 US clinical trials for Unresectable Malignant Solid Neoplasm, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Unresectable Malignant Solid Neoplasm?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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