Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Tobacco Dependence: full-pipeline trial registry
10 of 29 indexed Tobacco Dependence trials are currently recruiting.
Corpus placement: #552 of 28,707 conditions by registered trial count.
29 US clinical trials · 10 currently recruiting · #552 of 28,707 conditions by registered trial count
Tobacco Dependence: 29 US clinical trials tracked, 10 recruiting.
Tobacco Dependence is the subject of 29 registered US clinical trials on ClinicalTrials.gov, 10 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Johns Hopkins University, running 4 of these trials.
Enrollment posture brief
Registry condition tobacco-dependence
OPEN 10 | RECR 34% | LATE 6 | EARLY 5 | RANK #552 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Colitis, Ulcerative (34% recruiting · 29 trials)
Tobacco Dependence lists 10 open slots (34% of 29 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Tobacco Dependence on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Tobacco Dependence is recruiting below its size-band peers.
10 of 29 indexed trials (34.5%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Tobacco Dependence trials is spread across many organizations.
Johns Hopkins University accounts for 4 of 29 trials (13.8%). 21 distinct sponsors appear on at least one study for this condition label.
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Typical Tobacco Dependence enrolment sits around 240 participants.
Median target enrolment is 240 among the 29 trials that report a genuine target (sentinel values excluded). 6 of those (20.7%) plan for fewer than 100 participants.
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Tobacco Dependence research is mostly interventional.
29 interventional and 0 observational studies make up this index (100% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
29 total, page 1 of 1
Reach Through Equitable Implementation in Utah
University of Utah
NCT06881069
Smoke-free Home Study in Subsidized Housing
University of California, San Francisco
NCT06170437
FRESH Delivers: An Innovative Approach to Reducing Tobacco Use Among Rural Smokers
University of Arkansas
NCT05429892
Early Withdrawal Exposure and Negative Affect Withdrawal (NAW) Regulation Training for Smoking Cessation
University of Alabama at Birmingham
NCT03912194
Use of Nicotine Pouches Among Daily Smokers
Milton S. Hershey Medical Center
NCT06043362
Harm Reduction for Smokers With Mental Illness
Dartmouth-Hitchcock Medical Center
NCT06543407
Extended Intervention for Tobacco Use (EXIT) for People Experiencing Homelessness
University of California, San Francisco
NCT07148232
Cannabidiol for Reducing Cigarette Use
University of California, Los Angeles
NCT06218056
Oral Cannabidiol for Tobacco Cessation
Johns Hopkins University
NCT05445804
C-Raven, a Virtual Tobacco Cessation Intervention in Residency Clinics
Johns Hopkins University
NCT07220356
Assessment of Biomarkers in Children to Help Parents Quit Tobacco
Massachusetts General Hospital
NCT04832659
Provider and Peer Delivered Youth Smoking Intervention
University of Massachusetts, Worcester
NCT00435344
Helping Poor Smokers Quit
Washington University School of Medicine
NCT03194958
Evaluation of Tobacco Treatment Strategies for Inpatient Psychiatry
Stanford University
NCT00968513
Bupropion SR Plus Counseling for Smoking Cessation
University of Wisconsin, Madison
NCT01621009
System Based Tracking and Treatment for Emergency Patients Who Smoke: STTEPS
The Miriam Hospital
NCT01839903
Tobacco Treatment for Employable Californians, Total IMPACT Study
Stanford University
NCT02478697
Varenicline OTC Trial on Efficacy and Safety
Arizona State University
NCT03557294
The Appeal and Impact of E-cigarettes in Smokers With SMI
Dartmouth-Hitchcock Medical Center
NCT03050853
A Facebook Intervention for Young Sexual and Gender Minority Smokers
University of California, San Francisco
NCT03259360
Varenicline Effects on Cue Reactivity and Smoking Reward/Reinforcement
H. Lee Moffitt Cancer Center and Research Institute
NCT00747643
Innovative Digital Therapeutic for Smoking Cessation
My Digital Study
NCT03694327
S-Adenosyl-L-Methionine (SAMe) for Smoking Abstinence
Mayo Clinic
NCT00722124
Tobacco Dependence Treatment for Asian Americans
University of Massachusetts, Boston
NCT01091363
A Study of Novel Smoking Cessation Interventions in Current and Former Injection Drug Users
Johns Hopkins University
NCT01334736
Personalized Feedback for Smokers With Elevated Anxiety Sensitivity
University of Houston
NCT03382093
Effects of Yoga and Cardiovascular Exercise on Smoking Motivation
H. Lee Moffitt Cancer Center and Research Institute
NCT01423578
Very Low Nicotine Cigarettes in Smokers With Schizophrenia
Brown University
NCT02019459
C-Raven, a Virtual Tobacco Cessation Intervention in the Community
Johns Hopkins University
NCT06545669
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 4 |
| Phase 3 | 1 |
| Phase 4 | 5 |
Top Sponsors
Named interventions
Most-linked intervention names on Tobacco Dependence records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Tobacco Dependence trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Tobacco Dependence page
29 registered trials, 10 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 10 Tobacco Dependence trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Johns Hopkins University sponsors the most Tobacco Dependence trials on record, review their full trial history before evaluating a specific study. See Johns Hopkins University's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Tobacco Dependence condition card totals 29 registered trials; most-linked intervention Lung Cancer Screening; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.