Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT03912194 · ClinicalTrials.gov registry record · Phase 3
Early Withdrawal Exposure and Negative Affect Withdrawal (NAW) Regulation Training for Smoking Cessation
A Phase 3 study of Tobacco Dependence, sponsored by University of Alabama at Birmingham.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 400
- Enrollment target
- 1
- Study location
NCT03912194: Recruiting Phase 3 study of Tobacco Dependence, sponsored by University of Alabama at Birmingham.
NCT03912194 is a Phase 3 study of Tobacco Dependence that is actively recruiting participants, run by University of Alabama at Birmingham. The registered enrollment target is 400 participants, below the 464-participant average among 28 other Tobacco Dependence trials with a reported enrollment target (14% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03912194, a Phase 3 study of Tobacco Dependence, is actively recruiting participants, sponsored by University of Alabama at Birmingham.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 400 participants
- Enrollment target
- 1
- Study location
Study Summary
Smoking remains the single most preventable cause of morbidity and mortality in the United States, accounting for approximately half a million deaths every year. The current study will investigate the efficacy and mechanisms of change of a novel smoking cessation intervention. The current study will thus provide essential information regarding a treatment that has the potential to enhance the efficacy of existing smoking cessation interventions, thereby having a beneficial impact on the public health of the United States.
Primary Outcome
Self reported abstinence from smoking ("no smoking, not even a puff) in the past seven days, biochemically confirmed by a breath carbon monoxide reading of 3 or less
Conditions Studied
Interventions
- BEHAVIORAL cognitive-behavioral withdrawal regulation strategies
- BEHAVIORAL relaxation strategies
- BEHAVIORAL early withdrawal exposure
Study Locations (1)
Alabama
- Ryals Public Health Building - Birmingham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 400 participants |
| Start Date | 2019-08-01 |
| Est. Completion | 2026-07-01 |
| Phase | Phase 3 |
What NCT03912194 shows while recruiting
NCT03912194 is an interventional study that assigns participants to a tested intervention. The registered 400 participants enrollment target is mid-sized for trials with a published cap, below the 464-participant average among 28 other Tobacco Dependence trials with a reported enrollment target (14% lower).
The record links to 1 condition, with Tobacco Dependence appearing as the primary indexed condition, and to 3 interventions - of which cognitive-behavioral withdrawal regulation strategies is the first listed.
NCT03912194 reports a single indexed study location in Alabama.
Frequently Asked Questions
What is clinical trial NCT03912194 about?
NCT03912194 is a clinical study titled "Early Withdrawal Exposure and Negative Affect Withdrawal (NAW) Regulation Training for Smoking Cessation". Smoking remains the single most preventable cause of morbidity and mortality in the United States, accounting for approximately half a million deaths every year. The current study will investigate the efficacy and mechanisms of change of a novel smoking cessation intervention. The current study will...
What is the current status of trial NCT03912194?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 400 participants. The study started on 2019-08-01. Estimated completion is 2026-07-01.
What conditions does trial NCT03912194 study?
This clinical trial studies the following conditions: Tobacco Dependence.
What interventions are being tested in trial NCT03912194?
The interventions under investigation include: cognitive-behavioral withdrawal regulation strategies (BEHAVIORAL), relaxation strategies (BEHAVIORAL), early withdrawal exposure (BEHAVIORAL).
Who is sponsoring clinical trial NCT03912194?
This trial is sponsored by University of Alabama at Birmingham, which has 1,160 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03912194 being conducted?
This trial has 1 study location across Alabama. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Tobacco Dependence
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03912194's enrollment target sits among peer trials
400 10th of 28 higher than 19 of 28 other Tobacco Dependence trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Tobacco Dependence trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Harm Reduction for Smokers With Mental Illness
RECRUITING · NA
-
Cannabidiol for Reducing Cigarette Use
RECRUITING · Phase 2
-
Reach Through Equitable Implementation in Utah
RECRUITING · NA
-
FRESH Delivers: An Innovative Approach to Reducing Tobacco Use Among Rural Smokers
RECRUITING · NA
-
Extended Intervention for Tobacco Use (EXIT) for People Experiencing Homelessness
RECRUITING · Phase 4
-
Use of Nicotine Pouches Among Daily Smokers
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01665326 · 400 participants
Determination of CRIM Status and Longitudinal Follow-up of Individuals With Pompe Disease
- NCT02108054 · 400 participants · NA
Behavioral and Functional Task Development, Implementation, and Testing
- NCT02216500 · 400 participants · NA
Ketogenic Therapy Effects on Electrical and Metabolic Abnormalities in Epilepsy
- NCT02250352 · 400 participants
Core Biopsies for Establishing a Breast Tumor Tissue Repository
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI