Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Substance Use Disorder: early-phase trial registry
8 of 19 indexed Substance Use Disorder trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #902 of 28,707 conditions by registered trial count.
19 US clinical trials · 8 currently recruiting · #902 of 28,707 conditions by registered trial count
Substance Use Disorder: 19 US clinical trials tracked, 8 recruiting.
Substance Use Disorder is the subject of 19 registered US clinical trials on ClinicalTrials.gov, 8 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 3 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 5 of these trials.
Enrollment posture brief
Registry condition substance-use-disorder
OPEN 8 | RECR 42% | LATE 0 | EARLY 3 | RANK #902 | SPON 5
Volume-matched condition peers
Nearest open-share peer: Brain Concussion (42% recruiting · 19 trials)
Substance Use Disorder lists 8 open slots (42% of 19 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Substance Use Disorder on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Substance Use Disorder is recruiting below its size-band peers.
8 of 19 indexed trials (42.1%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Substance Use Disorder research.
VA Office of Research and Development accounts for 5 of 19 trials (26.3%). 13 distinct sponsors appear on at least one study for this condition label.
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Typical Substance Use Disorder enrolment sits around 152 participants.
Median target enrolment is 152 among the 19 trials that report a genuine target (sentinel values excluded). 7 of those (36.8%) plan for fewer than 100 participants.
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Substance Use Disorder research is mostly interventional.
18 interventional and 1 observational studies make up this index (94.7% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
19 total, page 1 of 1
Screening, Evaluation and Assessment (SEA) Protocol at the NIDA IRP
National Institute on Drug Abuse (NIDA)
NCT06552741
Defining Neurobiological Links Between Substance Use and Mental Illness
National Institute on Drug Abuse (NIDA)
NCT05538910
A Type I Hybrid Effectiveness-Implementation Trial of MIO
Baystate Medical Center
NCT07168642
OSA PAP Treatment for Veterans With SUD and PTSD on Residential Treatment Unit
VA Office of Research and Development
NCT05156112
A Digital Intervention to Decrease Self-Stigma Among Pregnant and Postpartum Women With Substance Use Disorder
Washington University School of Medicine
NCT07211867
Smoking Cessation CM for Veterans With or at Risk for Cancer
VA Office of Research and Development
NCT06432985
Personalized Approach to Healthy Use and Recovery (PATH) Trial
VA Office of Research and Development
NCT06580457
Successful Transitions and Reintegration Tools for Veterans (START-VETS)
VA Office of Research and Development
NCT04366531
Targeting Drug Memories With Methylphenidate
Icahn School of Medicine at Mount Sinai
NCT05978167
Peer Recovery Support Services for Individuals in Recovery Residences on MOUD
Potomac Health Foundations
NCT05616949
Neuromodulation in Substance Use Disorders
Manish Ranjan
NCT07010016
The Tobacco, Alcohol, Prescription Medication and Other Substances Tool
Friends Research Institute
NCT02110693
Testing the Leadership and Organizational Change for Implementation (LOCI) Intervention
University of California, San Diego
NCT03042832
Early Intervention for Minors in Possession of Alcohol/Drugs: A Feasibility Study
Oregon Research Institute
NCT01616212
Body-oriented Therapy for Women in SUD Treatment
University of Washington
NCT01960036
Innovative Digital Therapeutic for Smoking Cessation
My Digital Study
NCT03694327
Project IMPACT: In-the-Moment Protection From Automatic Capture by Trigger
Rutgers, The State University of New Jersey
NCT02579317
Mindful Awareness in Body-Oriented Therapy for Women's Substance Abuse Treatment
University of Washington
NCT01280916
Mindful Self Compassion for Combat Deployed Veterans With Moral Injury and Co-occurring PTSD-SUD
VA Office of Research and Development
NCT03681288
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
Top Sponsors
Named interventions
Most-linked intervention names on Substance Use Disorder records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Substance Use Disorder trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Substance Use Disorder page
19 registered trials, 8 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 8 Substance Use Disorder trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- VA Office of Research and Development sponsors the most Substance Use Disorder trials on record, review their full trial history before evaluating a specific study. See VA Office of Research and Development's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Substance Use Disorder condition card totals 19 registered trials; most-linked intervention Mindful Awareness in Body-oriented Therapy; top US site state Maryland. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.