Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Substance Abuse: early-phase trial registry
9 of 59 indexed Substance Abuse trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #241 of 28,707 conditions by registered trial count.
59 US clinical trials · 9 currently recruiting · #241 of 28,707 conditions by registered trial count
Substance Abuse: 59 US clinical trials tracked, 9 recruiting.
Substance Abuse is the subject of 59 registered US clinical trials on ClinicalTrials.gov, 9 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 14 in Phase 1-2 (earlier-stage). The most active sponsor is Yale University, running 6 of these trials.
Enrollment posture brief
Registry condition substance-abuse
OPEN 9 | RECR 15% | LATE 2 | EARLY 14 | RANK #241 | SPON 6
Volume-matched condition peers
Nearest open-share peer: Arthroplasty, Replacement, Knee (15% recruiting · 13 trials)
Substance Abuse lists 9 open slots (15% of 59 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Substance Abuse on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Substance Abuse is recruiting below its size-band peers.
9 of 59 indexed trials (15.3%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Substance Abuse trials is spread across many organizations.
Yale University accounts for 6 of 59 trials (10.2%). 38 distinct sponsors appear on at least one study for this condition label.
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Typical Substance Abuse enrolment sits around 144 participants.
Median target enrolment is 144 among the 59 trials that report a genuine target (sentinel values excluded). 25 of those (42.4%) plan for fewer than 100 participants.
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Substance Abuse research is mostly interventional.
53 interventional and 6 observational studies make up this index (89.8% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
59 total, page 2 of 2
Integration of Buprenorphine Into HIV Clinical Settings - Primary Care Model (PCM)
Yale University
NCT00798538
Computer Based Training in CBT in Primary Care
Yale University
NCT03013478
Evaluation of Atomoxetine for Cocaine Dependence: A Pilot Trial
Sharon Walsh
NCT00617201
Group Therapy for Women Prisoners With Comorbid Substance Use and Depression
Brown University
NCT00606996
Neuromodulation to Facilitate the Effect of Ketamine
The Neuroscience Center
NCT01816958
Improving Antihypertensive Medication Adherence
UConn Health
NCT01296594
Exercise as a Behavioral Treatment for Cocaine Dependence
Baylor College of Medicine
NCT01601743
Varenicline vs Placebo for the Treatment of Methamphetamine Dependence
University of California, Los Angeles
NCT01011829
Safety Interaction Trial Ibudilast and Methamphetamine
University of California, Los Angeles
NCT01217970
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 6 |
| Phase 2 | 8 |
| Phase 3 | 1 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Substance Abuse records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Substance Abuse trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Substance Abuse page
59 registered trials, 9 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 9 Substance Abuse trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Yale University sponsors the most Substance Abuse trials on record, review their full trial history before evaluating a specific study. See Yale University's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Substance Abuse condition card totals 59 registered trials; most-linked intervention Placebo; top US site state Connecticut. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.