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ClinicalTrials.gov enrollment closed early-phase tilt small index

Stage IV Cutaneous Melanoma AJCC v6 and v7: early-phase trial registry

A small indexed set (18 trials) with no open enrollment listed right now.

Corpus placement: #953 of 28,707 conditions by registered trial count.

18 US clinical trials · none currently recruiting · #953 of 28,707 conditions by registered trial count

Stage IV Cutaneous Melanoma AJCC v6 and v7: 18 US clinical trials tracked, none currently recruiting.

Stage IV Cutaneous Melanoma AJCC v6 and v7 is the subject of 18 registered US clinical trials on ClinicalTrials.gov, none currently recruiting. 1 are in Phase 3-4 (later-stage) and 17 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 12 of these trials.

Enrollment posture brief

Registry condition stage-iv-cutaneous-melanoma-ajcc-v6-and-v7

OPEN 0 | RECR 0% | LATE 1 | EARLY 17 | RANK #953 | SPON 12

Nearest open-share peer: Accelerated Phase Chronic Myelogenous Leukemia (0% recruiting · 12 trials)

Arrhythmias, Cardiac27.8%Androgenetic Alopecia16.7%Anemia, Sickle Cell16.7%Acquired Immunodeficiency Sy5.6%Stage IV Cutaneous Melan (th…0%
Open-enrollment share among volume-matched conditions near Stage IV Cutaneous Melanoma AJCC v6 and v7

Stage IV Cutaneous Melanoma AJCC v6 and v7 has no open enrollment in this registry pull (18 archived studies). Peers show how other volume-matched labels compare on open share. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Stage IV Cutaneous Melanoma AJCC v6 and v7 on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Stage IV Cutaneous Melanoma AJCC v6 and v7 is recruiting below its size-band peers.

    0 of 18 indexed trials (0%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates Stage IV Cutaneous Melanoma AJCC v6 and v7 research.

    National Cancer Institute (NCI) accounts for 12 of 18 trials (66.7%). 4 distinct sponsors appear on at least one study for this condition label.

  3. Most Stage IV Cutaneous Melanoma AJCC v6 and v7 trials plan to enrol fewer than 100 people.

    Median target enrolment is 62 among the 18 trials that report a genuine target (sentinel values excluded). 13 of those (72.2%) plan for fewer than 100 participants.

  4. Stage IV Cutaneous Melanoma AJCC v6 and v7 research is mostly interventional.

    18 interventional and 0 observational studies make up this index (100% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 16Phase 211Phase 31

Indexed trials (enrollment closed)

18 total, page 1 of 1

ACTIVE NOT RECRUITING Phase 3 1,673 participants

Ipilimumab or High-Dose Interferon Alfa-2b in Treating Patients With High-Risk Stage III-IV Melanoma That Has Been Removed by Surgery

National Cancer Institute (NCI)

NCT01274338

ACTIVE NOT RECRUITING Phase 2 600 participants

A Phase II/III Trial of Nivolumab, Ipilimumab, and GM-CSF in Patients With Advanced Melanoma

National Cancer Institute (NCI)

NCT02339571

ACTIVE NOT RECRUITING Phase 2 280 participants

Testing Two Different Treatment Schedules of Dabrafenib and Trametinib for Skin Cancer Which Has Spread

National Cancer Institute (NCI)

NCT02196181

ACTIVE NOT RECRUITING Phase 2 245 participants

Ipilimumab With or Without Sargramostim in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery

National Cancer Institute (NCI)

NCT01134614

ACTIVE NOT RECRUITING Phase 2 88 participants

Ipilimumab With or Without High-Dose Recombinant Interferon Alfa-2b in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery

National Cancer Institute (NCI)

NCT01708941

ACTIVE NOT RECRUITING Phase 2 72 participants

Dinaciclib in Treating Patients With Stage IV Melanoma

National Cancer Institute (NCI)

NCT00937937

ACTIVE NOT RECRUITING Phase 1 70 participants

Aerosolized Aldesleukin in Treating Patients With Lung Metastases

M.D. Anderson Cancer Center

NCT01590069

ACTIVE NOT RECRUITING Phase 1 62 participants

Akt Inhibitor MK2206 and Hydroxychloroquine in Treating Patients With Advanced Solid Tumors, Melanoma, Prostate or Kidney Cancer

National Cancer Institute (NCI)

NCT01480154

ACTIVE NOT RECRUITING Phase 2 52 participants

Nivolumab With Trametinib and Dabrafenib, or Encorafenib and Binimetinib in Treating Patients With BRAF Mutated Metastatic or Unresectable Stage III-IV Melanoma

M.D. Anderson Cancer Center

NCT02910700

ACTIVE NOT RECRUITING Phase 2 43 participants

Talimogene Laherparepvec and Pembrolizumab in Treating Patients With Stage III-IV Melanoma

National Cancer Institute (NCI)

NCT02965716

ACTIVE NOT RECRUITING Phase 1 35 participants

Riluzole and Sorafenib Tosylate in Treating Patients With Advanced Solid Tumors or Melanoma

National Cancer Institute (NCI)

NCT01303341

ACTIVE NOT RECRUITING Phase 1 34 participants

Genetically Modified T-Cells Followed by Aldesleukin in Treating Patients With Stage III-IV Melanoma

M.D. Anderson Cancer Center

NCT01955460

ACTIVE NOT RECRUITING Phase 1 20 participants

Pembrolizumab and Ibrutinib in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery

Mayo Clinic

NCT03021460

ACTIVE NOT RECRUITING Phase 1 19 participants

Cediranib Maleate and Selumetinib Sulfate in Treating Patients With Solid Malignancies

National Cancer Institute (NCI)

NCT01364051

ACTIVE NOT RECRUITING Phase 2 18 participants

Ibrutinib in Treating Patients With Refractory Metastatic Cutaneous Melanoma

National Cancer Institute (NCI)

NCT02581930

COMPLETED Phase 2 169 participants

Ipilimumab With or Without Bevacizumab in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery

National Cancer Institute (NCI)

NCT01950390

COMPLETED Phase 2 18 participants

Pembrolizumab, Standard Chemotherapy, Tumor Infiltrating Lymphocytes, and High- or Low-Dose Aldesleukin in Treating Patients With Metastatic Melanoma

M.D. Anderson Cancer Center

NCT02500576

COMPLETED Phase 2 11 participants

Tumor-Infiltrating Lymphocytes After Combination Chemotherapy in Treating Patients With Metastatic Melanoma

Fred Hutchinson Cancer Center

NCT01807182

Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 11
Phase 3 1

Named interventions

Most-linked intervention names on Stage IV Cutaneous Melanoma AJCC v6 and v7 records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Laboratory Biomarker Analysis Other
10 trials
Ipilimumab Biological
5 trials
Pharmacological Study Other
3 trials
Aldesleukin Biological
3 trials
Fludarabine Phosphate Drug
3 trials
Cyclophosphamide Drug
3 trials
Pembrolizumab Biological
3 trials
Recombinant Interferon Alfa-2b Biological
2 trials

US sites by state

Facility locations filed on Stage IV Cutaneous Melanoma AJCC v6 and v7 trials. A trial with sites in several states counts in each.

Alabama 8 trials
California 7 trials
Texas 4 trials
Arizona 4 trials
Arkansas 4 trials
Colorado 3 trials
Ohio 2 trials
New Jersey 2 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Stage IV Cutaneous Melanoma AJCC v6 and v7 page

18 registered trials, 0 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

  • No Stage IV Cutaneous Melanoma AJCC v6 and v7 trials are currently recruiting in this registry; that can change as new trials post, or check the broader research index. Browse research indexes
  • National Cancer Institute (NCI) sponsors the most Stage IV Cutaneous Melanoma AJCC v6 and v7 trials on record, review their full trial history before evaluating a specific study. See National Cancer Institute (NCI)'s trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Stage IV Cutaneous Melanoma AJCC v6 and v7 condition card totals 18 registered trials; most-linked intervention Laboratory Biomarker Analysis; top US site state Alabama. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.