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ClinicalTrials.gov 4 recruiting now official registry

Stage IIIA Rectal Cancer AJCC v8 clinical trials

4 of 9 indexed Stage IIIA Rectal Cancer AJCC v8 trials are currently recruiting.

9 US clinical trials · 4 currently recruiting

Stage IIIA Rectal Cancer AJCC v8 is the subject of 9 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 7 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 4 of these trials.

The research picture

Stage IIIA Rectal Cancer AJCC v8 has 9 registered US clinical trials, 4 of them open to new participants right now, about 44% of the total.

4
recruiting participants now
44%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
4
top sponsor: M.D. Anderson Cancer Center
Phase 16Phase 21

Active & Recent Trials

9 total, page 1 of 1

RECRUITING Early Phase 1 120 participants

Active Surveillance and Chemotherapy Before Surgery in Treating Participants With Stage II-III Rectal Cancer

M.D. Anderson Cancer Center

NCT03594630

RECRUITING 50 participants

Establishing a ctDNA Biomarker to Improve Organ Preserving Strategies in Patients With Rectal Cancer

OHSU Knight Cancer Institute

NCT05081024

RECRUITING Phase 1 25 participants

Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer

Jonsson Comprehensive Cancer Center

NCT04703101

RECRUITING Early Phase 1 15 participants

An Investigational Scan (64Cu-Labeled M5A Antibody) in Combination With SOC Chemotherapy and Radiotherapy in Locally Advanced Rectal Cancer

City of Hope Medical Center

NCT05245786

ACTIVE NOT RECRUITING 341 participants

Circulating Tumor Cells in Patients With Locally Advanced Rectal Cancer

M.D. Anderson Cancer Center

NCT02874885

ACTIVE NOT RECRUITING Phase 1 51 participants

SX-682 and Nivolumab for the Treatment of RAS-Mutated, MSS Unresectable or Metastatic Colorectal Cancer, the STOPTRAFFIC-1 Trial

M.D. Anderson Cancer Center

NCT04599140

ACTIVE NOT RECRUITING Phase 1 46 participants

LY3214996 and Cetuximab Alone or in Combination With Abemaciclib for the Treatment of Unresectable or Metastatic Colorectal Cancer

M.D. Anderson Cancer Center

NCT04616183

ACTIVE NOT RECRUITING Phase 1 19 participants

TAS-102 With Concurrent Radiation for the Treatment of Untreated Resectable Stage II-III Rectal Cancer

OHSU Knight Cancer Institute

NCT04104139

ACTIVE NOT RECRUITING Phase 2 12 participants

Panitumumab, Regorafenib, or TAS-102, in Treating Patients With Metastatic and/or Unresectable RAS Wild-Type Colorectal Cancer

Academic and Community Cancer Research United

NCT03992456

Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Stage IIIA Rectal Cancer AJCC v8 Trial Landscape

9 indexed Stage IIIA Rectal Cancer AJCC v8 studies · 4 recruiting (44%).

Phase mix: 0 late (III/IV) vs 7 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (4 trials), 4 others listed. 9 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Stage IIIA Rectal Cancer AJCC v8?

PlainTrial tracks 9 US clinical trials for Stage IIIA Rectal Cancer AJCC v8, of which 4 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Stage IIIA Rectal Cancer AJCC v8?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.