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NCT05081024 · ClinicalTrials.gov registry record
Establishing a ctDNA Biomarker to Improve Organ Preserving Strategies in Patients With Rectal Cancer
A clinical trial of Rectal Adenocarcinoma and Stage III Rectal Cancer AJCC v8, sponsored by OHSU Knight Cancer Institute.
- Recruiting
- Registry status
- 50
- Enrollment target
- 2
- Study locations
NCT05081024: Recruiting study of Rectal Adenocarcinoma and Stage III Rectal Cancer AJCC v8, sponsored by OHSU Knight Cancer Institute.
NCT05081024 is a study of Rectal Adenocarcinoma and Stage III Rectal Cancer AJCC v8 that is actively recruiting participants, run by OHSU Knight Cancer Institute. The registered enrollment target is 50 participants, below the 122-participant average among 17 other Rectal Adenocarcinoma trials with a reported enrollment target (59% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05081024, a study of Rectal Adenocarcinoma and Stage III Rectal Cancer AJCC v8, is actively recruiting participants, sponsored by OHSU Knight Cancer Institute.
- RECRUITING
- Registry status
- 50 participants
- Enrollment target
- 2
- Study locations
Study Summary
This study measures the levels of circulating tumor DNA (ctDNA) in patients with stage II-III rectal cancer before, during, and after treatment to find out if the presence or absence of ctDNA in patient's blood using the Signatera test can be used to gauge how different treatments may affect rectal cancer. ctDNA is DNA from the rectal cancer that is circulating in the blood. The purpose of this study is to understand if the way rectal tumors respond to standard treatment can be associated with varying levels of ctDNA.
Primary Outcome
cCR following TNT will be analyzed using the TNT analysis set. Proportions of participants that achieved cCR will be calculated and the exact 95% confidence interval (CI) will be presented.
Conditions Studied
Interventions
- PROCEDURE Biospecimen Collection
- PROCEDURE Biopsy
- OTHER Electronic Health Record Review
Study Locations (2)
Oregon
- OHSU Knight Cancer Institute - Portland
Washington
- Fred Hutch - Seattle
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2021-09-03 |
| Est. Completion | 2026-09-03 |
What NCT05081024 shows while recruiting
NCT05081024 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 122-participant average among 17 other Rectal Adenocarcinoma trials with a reported enrollment target (59% lower).
The record links to 9 conditions, with Rectal Adenocarcinoma appearing as the primary indexed condition, and to 3 interventions - of which Biospecimen Collection is the first listed.
NCT05081024 reports a single indexed study location in Oregon, Washington.
Frequently Asked Questions
What is clinical trial NCT05081024 about?
NCT05081024 is a clinical study titled "Establishing a ctDNA Biomarker to Improve Organ Preserving Strategies in Patients With Rectal Cancer". This study measures the levels of circulating tumor DNA (ctDNA) in patients with stage II-III rectal cancer before, during, and after treatment to find out if the presence or absence of ctDNA in patient's blood using the Signatera test can be used to gauge how different treatments may affect rectal ...
What is the current status of trial NCT05081024?
This trial is currently recruiting. The enrollment target is 50 participants. The study started on 2021-09-03. Estimated completion is 2026-09-03.
What conditions does trial NCT05081024 study?
This clinical trial studies the following conditions: Rectal Adenocarcinoma, Stage III Rectal Cancer AJCC v8, Stage II Rectal Cancer AJCC v8, Stage IIIA Rectal Cancer AJCC v8, Stage IIIB Rectal Cancer AJCC v8.
What interventions are being tested in trial NCT05081024?
The interventions under investigation include: Biospecimen Collection (PROCEDURE), Biopsy (PROCEDURE), Electronic Health Record Review (OTHER).
Who is sponsoring clinical trial NCT05081024?
This trial is sponsored by OHSU Knight Cancer Institute, which has 211 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05081024 being conducted?
This trial has 2 study locations across Oregon, Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Rectal Adenocarcinoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05081024's enrollment target sits among peer trials
50 6th of 17 higher than 11 of 17 other Rectal Adenocarcinoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Rectal Adenocarcinoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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