Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Severe Sepsis: early-phase trial registry
A small indexed set (10 trials) with no open enrollment listed right now.
Corpus placement: #1,724 of 28,707 conditions by registered trial count.
10 US clinical trials · none currently recruiting · #1,724 of 28,707 conditions by registered trial count
Severe Sepsis: 10 US clinical trials tracked, none currently recruiting.
Severe Sepsis is the subject of 10 registered US clinical trials on ClinicalTrials.gov, none currently recruiting. 1 are in Phase 3-4 (later-stage) and 3 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of General Medical Sciences (NIGMS), running 1 of these trials.
Enrollment posture brief
Registry condition severe-sepsis
OPEN 0 | RECR 0% | LATE 1 | EARLY 3 | RANK #1724 | SPON 1
Volume-matched condition peers
Nearest open-share peer: Accelerated Phase Chronic Myelogenous Leukemia (0% recruiting · 12 trials)
Severe Sepsis has no open enrollment in this registry pull (10 archived studies). Peers show how other volume-matched labels compare on open share. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Severe Sepsis on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Severe Sepsis is recruiting below its size-band peers.
0 of 10 indexed trials (0%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Severe Sepsis trials is spread across many organizations.
National Institute of General Medical Sciences (NIGMS) accounts for 1 of 10 trials (10%). 10 distinct sponsors appear on at least one study for this condition label.
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Typical Severe Sepsis enrolment sits around 330 participants.
Median target enrolment is 330 among the 10 trials that report a genuine target (sentinel values excluded). 2 of those (20%) plan for fewer than 100 participants.
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Severe Sepsis research is mostly interventional.
7 interventional and 3 observational studies make up this index (70% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Indexed trials (enrollment closed)
10 total, page 1 of 1
Monocyte Distribution Width (MDW) in the General Population of Emergency Department Patients With and Without Bacteremia
Henry Ford Health System
NCT05296590
Zinc Therapy in Critical Illness
University of Vermont
NCT01162109
Predictive algoRithm for EValuation and Intervention in SEpsis
Dascena
NCT03235193
ACCESS: A Controlled Comparison of Eritoran Tetrasodium and Placebo in Patients With Severe Sepsis
Eisai
NCT00334828
Evaluate Protein C Levels in Severe Sepsis Patients on Drotrecogin Alfa (Activated)
Eli Lilly and Company
NCT00386425
Antibiotic Administration and Blood Culture Positivity in Severe Sepsis and Septic Shock
University of British Columbia
NCT01867905
Clinical Trial of the Optimal Endpoint of Early Sepsis Resuscitation
National Institute of General Medical Sciences (NIGMS)
NCT00372502
Ultrasound Measurement of Reactive Hyperemia in Critical Care
University of Rochester
NCT01726595
Preemptive Resuscitation for Eradication of Septic Shock
Christiana Care Health Services
NCT01449721
A Study of Nivolumab Safety and Pharmacokinetics in Patients With Severe Sepsis or Septic Shock.
Bristol-Myers Squibb
NCT02960854
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 1 |
| Phase 3 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Severe Sepsis records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Severe Sepsis trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Severe Sepsis page
10 registered trials, 0 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- No Severe Sepsis trials are currently recruiting in this registry; that can change as new trials post, or check the broader research index. Browse research indexes
- National Institute of General Medical Sciences (NIGMS) sponsors the most Severe Sepsis trials on record, review their full trial history before evaluating a specific study. See National Institute of General Medical Sciences (NIGMS)'s trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Severe Sepsis condition card totals 10 registered trials; most-linked intervention Standard EGDT; top US site state North Carolina. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.