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ClinicalTrials.gov 4 recruiting now official registry

Secondary Myelofibrosis clinical trials

4 of 13 indexed Secondary Myelofibrosis trials are currently recruiting.

13 US clinical trials · 4 currently recruiting

Secondary Myelofibrosis is the subject of 13 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 13 in Phase 1-2 (earlier-stage). The most active sponsor is Fred Hutchinson Cancer Center, running 4 of these trials.

The research picture

Secondary Myelofibrosis has 13 registered US clinical trials, 4 of them open to new participants right now, about 31% of the total.

4
recruiting participants now
31%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
4
top sponsor: Fred Hutchinson Cancer Center
Phase 12Phase 211

Active & Recent Trials

13 total, page 1 of 1

RECRUITING Phase 2 62 participants

A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative Neoplasms (MPNs)

National Cancer Institute (NCI)

NCT06661915

RECRUITING Phase 2 50 participants

Ruxolitinib Before, During and After Hematopoietic Cell Transplant in Older Patients With Myelofibrosis and Myelodysplastic Syndrome/Myeloproliferative Neoplasm Overlap Syndromes

Fred Hutchinson Cancer Center

NCT07228624

RECRUITING Phase 2 25 participants

Decitabine With Ruxolitinib, Fedratinib or Pacritinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms

University of Washington

NCT04282187

RECRUITING Phase 2 20 participants

Reduced Intensity Haploidentical Transplantation for the Treatment of Primary or Secondary Myelofibrosis

Fred Hutchinson Cancer Center

NCT04370301

ACTIVE NOT RECRUITING Phase 2 61 participants

JAK Inhibitor Before Donor Stem Cell Transplant in Treating Patients With Primary or Secondary Myelofibrosis

Fred Hutchinson Cancer Center

NCT02251821

ACTIVE NOT RECRUITING Phase 2 59 participants

Itacitinib, Tacrolimus, and Sirolimus for the Prevention of GVHD in Patients With Acute Leukemia, Myelodysplastic Syndrome, or Myelofibrosis Undergoing Reduced Intensity Conditioning Donor Stem Cell Transplantation

City of Hope Medical Center

NCT04339101

ACTIVE NOT RECRUITING Phase 2 53 participants

Peritransplant Ruxolitinib for Patients With Primary and Secondary Myelofibrosis

Fred Hutchinson Cancer Center

NCT04384692

ACTIVE NOT RECRUITING Phase 1 22 participants

Combination Chemotherapy, Total Body Irradiation, and Donor Blood Stem Cell Transplant in Treating Patients With Secondary Myelofibrosis

City of Hope Medical Center

NCT03118492

ACTIVE NOT RECRUITING Phase 2 21 participants

Decitabine in Treating Patients With Myelofibrosis

National Cancer Institute (NCI)

NCT00095784

ACTIVE NOT RECRUITING Phase 2 20 participants

Adding Itacitinib to Cyclophosphamide and Tacrolimus for the Prevention of Graft Versus Host Disease in Patients Undergoing Hematopoietic Stem Cell Transplants

City of Hope Medical Center

NCT05364762

COMPLETED Phase 2 80 participants

Imetelstat Sodium in Treating Participants With Primary or Secondary Myelofibrosis

Geron Corporation

NCT01731951

COMPLETED Phase 2 32 participants

Sirolimus, Tacrolimus, and Antithymocyte Globulin in Preventing Graft-Versus-Host Disease in Patients Undergoing a Donor Stem Cell Transplant For Hematological Cancer

City of Hope Medical Center

NCT00589563

COMPLETED Early Phase 1 3 participants

Combination Chemotherapy, Total Body Irradiation, and Donor Blood Stem Cell Transplant in Treating Patients With Primary or Secondary Myelofibrosis

M.D. Anderson Cancer Center

NCT03426969

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 11

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Secondary Myelofibrosis Trial Landscape

13 indexed Secondary Myelofibrosis studies · 4 recruiting (31%).

Phase mix: 0 late (III/IV) vs 13 early (I/II).

Top sponsor: Fred Hutchinson Cancer Center (4 trials), 5 others listed. 13 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Secondary Myelofibrosis?

PlainTrial tracks 13 US clinical trials for Secondary Myelofibrosis, of which 4 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Secondary Myelofibrosis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.