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ClinicalTrials.gov 7 recruiting now official registry

Renal Impairment clinical trials

7 of 33 indexed Renal Impairment trials are currently recruiting.

33 US clinical trials · 7 currently recruiting

Renal Impairment is the subject of 33 registered US clinical trials on ClinicalTrials.gov, 7 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 32 in Phase 1-2 (earlier-stage). The most active sponsor is Pfizer, running 3 of these trials.

The research picture

Renal Impairment has 33 registered US clinical trials, 7 of them open to new participants right now, about 21% of the total.

7
recruiting participants now
21%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
3
top sponsor: Pfizer
Phase 132

Active & Recent Trials

33 total, page 1 of 1

RECRUITING NA 124 participants

Groundbreaking Renal Assist Device Intervening to ENhance cardioThoracic Surgery Outcomes

3ive Labs

NCT07017933

RECRUITING Phase 1 50 participants

Investigation of the Effects of Renal Impairment on the Pharmacokinetics, Safety, and Tolerability of Opemalirsen (AZD2373)

AstraZeneca

NCT07154901

RECRUITING Phase 1 40 participants

A Study of S-892216-PO in Participants With Renal Impairment and Matched Controls

Shionogi

NCT07217886

RECRUITING Phase 1 28 participants

Study of Bemnifosbuvir/Ruzasvir as a Fixed-dose Combination in Subjects With Normal or Severely Impaired Renal or Hepatic Function

Atea Pharmaceuticals

NCT06911320

RECRUITING Phase 1 28 participants

A Study to Learn How the Body Processes the Study Medicine PF-07328948 in People With Reduced Kidney Function

Pfizer

NCT07315360

RECRUITING Phase 1 28 participants

A Study of Eloralintide (LY3841136) in Participants With Renal Impairment and in Participants With Normal Renal Function

Eli Lilly and Company

NCT07426380

RECRUITING Phase 1 24 participants

A Clinical Trial of MK-2828 in People With Kidney Disease (MK-2828-006)

Merck Sharp & Dohme

NCT07348237

ACTIVE NOT RECRUITING Phase 1 32 participants

A Study of Pharmacokinetics and Safety of LY3537031 in Participants With Normal Renal Function and Participants With Renal Impairment

Eli Lilly and Company

NCT07165015

COMPLETED Phase 1 62 participants

Effect of Renal Impairment on the Pharmacokinetics of NN9535

Novo Nordisk A/S

NCT00833716

COMPLETED Phase 1 58 participants

A Study to Evaluate Pharmacokinetic and Safety Trial of Emraclidine in Participants With Renal Impairment Compared With Participants With Normal Renal Function

AbbVie

NCT05940402

COMPLETED Phase 1 58 participants

Pharmacokinetics of LCQ908 in Patients With Renal Impairment

Novartis Pharmaceuticals

NCT01558323

COMPLETED Phase 1 48 participants

To Investigate The Pharmacokinetics Of Intravenous WCK 5222 (FEP-ZID) In Patients With Renal Impairment

Wockhardt

NCT02942810

COMPLETED Phase 1 46 participants

Pharmacokinetic Study of AR882 in Subjects With Various Degrees of Renal Impairment

Arthrosi Therapeutics

NCT04646889

COMPLETED Phase 1 42 participants

Study OF PF-06882961 IN Participants With Type 2 Diabetes Mellitus With Varying Degrees OF Renal Impairment AND Participants Without Renal Impairment

Pfizer

NCT04616027

COMPLETED Phase 1 33 participants

A Study to Evaluate the Pharmacokinetics, Safety, and Pharmacodynamics of Olpasiran in Participants With Normal Renal Function and Participants With Various Degrees of Renal Impairment

Amgen

NCT05489614

COMPLETED Phase 1 33 participants

A Pharmacokinetic Study of YM178 in Normal Subjects and Those With Mild, Moderate, and Severe Renal Impairment

Astellas Pharma

NCT00750620

COMPLETED Phase 1 32 participants

A Single-Dose Study to Assess the Pharmacokinetics of Cabozantinib (XL184) Capsules in Subjects With Impaired Renal Function

Exelixis

NCT01761773

COMPLETED Phase 1 32 participants

Multiple Dose Study to Evaluate the Safety of Multiple Doses of Denosumab 120 mg in Adults With Severe Chronic Kidney Disease (CKD) and CKD on Dialysis

Amgen

NCT01464931

COMPLETED Phase 1 32 participants

Pharmacokinetics, Safety and Tolerability of AGO178C in Subjects With Renal Deficiencies Compared With Healthy Subjects

Novartis Pharmaceuticals

NCT01459250

COMPLETED Phase 1 28 participants

A Study About How ASP5354 Affects the Body in Healthy Adults and in Adults Whose Kidneys do Not Work Well

Astellas Pharma Global Development

NCT05495581

COMPLETED Phase 1 26 participants

A Study to Evaluate the Drug Levels of Mezigdomide in Adult Participants With Renal Impairment

Celgene

NCT06318676

COMPLETED Phase 1 25 participants

Study of Pomalidomide to Evaluate the Pharmacokinetics and Safety for Patients With Multiple Myeloma and Impaired Renal Function (POM Renal)

Celgene

NCT01575925

COMPLETED Phase 1 25 participants

Safety and Pharmacokinetics Study of MBX 2109 in Adult Subjects With Normal and Impaired Renal Function

MBX Biosciences

NCT06496217

COMPLETED Phase 1 24 participants

Fruquintinib Renal Impairment Study

Hutchmed

NCT05216354

COMPLETED Phase 1 23 participants

Safety, Pharmacokinetics (PK), And Hematological Activity Of AMD3100 (Plerixafor) In Subjects With Renal Impairment

Genzyme, a Sanofi Company

NCT00445302

COMPLETED Phase 1 22 participants

Study to Assess the Plasma Concentration of Tolebrutinib Given as a Tablet to Adult Participants With Renal Impairment Compared to Healthy Participants.

Sanofi

NCT05282030

COMPLETED Phase 1 20 participants

Study to Determine How Cialis Effects the Renal Function in Response to Volume Expansion in Preclinical Systolic Cardiomyopathy (Aim2)

Mayo Clinic

NCT01970176

COMPLETED Phase 1 16 participants

Evaluation of Effect of Renal Impairment on the PK of Tenofovir Exalidex

ContraVir Pharmaceuticals

NCT03284164

COMPLETED Phase 1 16 participants

A Single Dose Evaluation of the Effects of Renal Impairment on Deflazacort Pharmacokinetics

PTC Therapeutics

NCT02286622

COMPLETED Phase 1 16 participants

A Study to Learn How the Body Processes the Study Medicine Called PF-07923568 in People With Loss of Kidney Function

Pfizer

NCT06037031

COMPLETED Phase 1 16 participants

Phase 1 Study of PK and Safety of HM15912 (Sonefpeglutide) in Subjects With Normal and Severe Kidney Function

Hanmi Pharmaceutical Company Limited

NCT05711381

COMPLETED Phase 1 12 participants

Single-Dose Study to Evaluate the PKs of Pretomanid in Participants With Renal Impairment Compared to Participants With Normal Renal Function

National Institute of Allergy and Infectious Diseases (NIAID)

NCT03896750

COMPLETED Phase 1 6 participants

A Study to Evaluate the Safety and Pharmacokinetics of BMS-986177 in Participants With End-stage Renal Dysfunction on Chronic Stable Hemodialysis Treatment

Bristol-Myers Squibb

NCT02902679

Phase Distribution

PhaseTrial count
Phase 1 32

Top Sponsors

Pfizer 3 trials
Celgene 2 trials
Amgen 2 trials
Wockhardt 1 trials
PTC Therapeutics 1 trials
Hutchmed 1 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Renal Impairment Trial Landscape

33 indexed Renal Impairment studies · 7 recruiting (21%).

Phase mix: 0 late (III/IV) vs 32 early (I/II).

Top sponsor: Pfizer (3 trials), 9 others listed. 33 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Renal Impairment?

PlainTrial tracks 33 US clinical trials for Renal Impairment, of which 7 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Renal Impairment?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.