Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT01575925 · ClinicalTrials.gov registry record · Phase 1
Study of Pomalidomide to Evaluate the Pharmacokinetics and Safety for Patients With Multiple Myeloma and Impaired Renal Function (POM Renal)
A Phase 1 study of Multiple Myeloma and Renal Impairment, sponsored by Celgene.
- Completed
- Registry status
- Phase 1
- Development phase
- 25
- Enrollment target
- 9
- Study locations
NCT01575925: Completed Phase 1 study of Multiple Myeloma and Renal Impairment, sponsored by Celgene.
NCT01575925 is a Phase 1 study of Multiple Myeloma and Renal Impairment that has completed, run by Celgene. The registered enrollment target is 25 participants, below the 547-participant average among 438 other Multiple Myeloma trials with a reported enrollment target (95% lower). The trial reports 9 study locations across 9 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01575925, a Phase 1 study of Multiple Myeloma and Renal Impairment, has completed, sponsored by Celgene.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 25 participants
- Enrollment target
- 9
- Study locations
Study Summary
The purpose of this study is to determine the pharmacokinetics (PK) and safety for the combination of pomalidomide (POM) + low-dose dexamethasone (LD- DEX) in subjects with relapsed or refractory Multiple Myeloma (RRMM) and impaired renal function.
Primary Outcome
PK-Area under the plasma concentration time curve (AUC)
Conditions Studied
Interventions
- DRUG 4 mg Oral POM + 40 mg Oral DEX
- DRUG 2 mg Oral POM + 40 mg Oral DEX
Study Locations (9)
Colorado
- Colorado Blood Cancer Institute - Denver
Georgia
- Winship Cancer Institute of Emory University - Atlanta
Illinois
- Ingalls Cancer Research Center - Harvey
New Jersey
- Hackensack University Medical Center - Hackensack
New York
- Weill Cornell Medical College - New York
Ohio
- Cleveland Clinic - Cleveland
Texas
- MD Anderson Cancer Center - Houston
Nova Scotia
- Queen Elizabeth II Health Sciences Centre - Halifax
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 25 participants |
| Start Date | 2012-06-01 |
| Est. Completion | 2018-08-07 |
| Phase | Phase 1 |
What the finished NCT01575925 record still lists
NCT01575925 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 25 participants, a relatively small participant target, below the 547-participant average among 438 other Multiple Myeloma trials with a reported enrollment target (95% lower).
The record links to 2 conditions, with Multiple Myeloma appearing as the primary indexed condition, and to 2 interventions - of which 4 mg Oral POM + 40 mg Oral DEX is the first listed.
NCT01575925 lists 9 locations in 9 states (Colorado, Georgia, Illinois).
Frequently Asked Questions
What is clinical trial NCT01575925 about?
NCT01575925 is a clinical study titled "Study of Pomalidomide to Evaluate the Pharmacokinetics and Safety for Patients With Multiple Myeloma and Impaired Renal Function (POM Renal)". The purpose of this study is to determine the pharmacokinetics (PK) and safety for the combination of pomalidomide (POM) + low-dose dexamethasone (LD- DEX) in subjects with relapsed or refractory Multiple Myeloma (RRMM) and impaired renal function.
What is the current status of trial NCT01575925?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 25 participants. The study started on 2012-06-01. Estimated completion is 2018-08-07.
What conditions does trial NCT01575925 study?
This clinical trial studies the following conditions: Multiple Myeloma, Renal Impairment.
What interventions are being tested in trial NCT01575925?
The interventions under investigation include: 4 mg Oral POM + 40 mg Oral DEX (DRUG), 2 mg Oral POM + 40 mg Oral DEX (DRUG).
Who is sponsoring clinical trial NCT01575925?
This trial is sponsored by Celgene, which has 308 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01575925 being conducted?
This trial has 9 study locations across Colorado, Georgia, Illinois, New Jersey, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Multiple Myeloma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT01575925's enrollment target sits among peer trials
25 366th of 438 higher than 63 of 438 other Multiple Myeloma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Multiple Myeloma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
A Study to Investigate the Safety and Efficacy of Belantamab for the Treatment of Multiple Myeloma When Used as Monotherapy and in Combination Treatments
RECRUITING · Phase 1
-
TriPRIL CAR T Cells in Multiple Myeloma
RECRUITING · Phase 1
-
A Study to Assess Adverse Events and Change in Disease Activity of Oral ABBV-453 Alone or in Combination With Subcutaneous and/or Oral Antimyeloma Agents in Adult Participants With Multiple Myeloma (MM)
RECRUITING · Phase 1
-
AZD0305 as Monotherapy or in Combination With Anticancer Agents in Participants With Relapsed/Refractory Multiple Myeloma
RECRUITING · Phase 1
-
Study of Carfilzomib, Lenalidomide, Dexamethasone and Belantamab Mafodotin in Multiple Myeloma
RECRUITING · Phase 1
-
CRISPR Delivered Anti-BCMA Car-T Therapy for Relapsed or Refractory Multiple Myeloma
RECRUITING · Phase 1
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01166854 · 25 participants
Characterization of Familial Myopathy and Paget Disease of Bone
- NCT01913106 · 25 participants · Phase 1
HSV-tk + Valacyclovir Therapy in Combination With Brachytherapy for Recurrent Prostate Cancer
- NCT02138669 · 25 participants · NA
Intacs Prescription Inserts for Keratoconus Patients
- NCT02174549 · 25 participants · Phase 1
Dose-defining Study of Tirapazamine Combined With Embolization in Liver Cancer
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI