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ClinicalTrials.gov 6 recruiting now official registry

REM Sleep Behavior Disorder clinical trials

6 of 12 indexed REM Sleep Behavior Disorder trials are currently recruiting.

12 US clinical trials · 6 currently recruiting

REM Sleep Behavior Disorder is the subject of 12 registered US clinical trials on ClinicalTrials.gov, 6 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Cedars-Sinai Medical Center, running 3 of these trials.

The research picture

REM Sleep Behavior Disorder has 12 registered US clinical trials, 6 of them open to new participants right now, about 50% of the total.

6
recruiting participants now
50%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
3
top sponsor: Cedars-Sinai Medical Center
Phase 11Phase 24Phase 41

Active & Recent Trials

12 total, page 1 of 1

RECRUITING 800 participants

Natural History Study of Synucleinopathies

NYU Langone Health

NCT01799915

RECRUITING 500 participants

North American Prodromal Synucleinopathy Consortium Stage 2

Washington University School of Medicine

NCT05826457

RECRUITING 100 participants

Intestinal Immunity in Neurologic Disease

Yale University

NCT06329453

RECRUITING NA 86 participants

Neuroplasticity in RBD

University of Minnesota

NCT05471960

RECRUITING NA 60 participants

Identification of Prodromal Neurodegeneration in Serotonergic-Induced REM Sleep Behavior Disorder

University of Minnesota

NCT06467461

RECRUITING NA 20 participants

Behavioral Treatment for Nightmares in REM Sleep Behavior Disorder

University of Utah

NCT06441864

ACTIVE NOT RECRUITING Phase 2 15 participants

Cardiac Changes in Early Parkinson's Disease: A Follow up Study

Cedars-Sinai Medical Center

NCT04218968

ACTIVE NOT RECRUITING Phase 2 15 participants

Terazosin Effect on Cardiac Changes in Early Parkinson's Disease

Cedars-Sinai Medical Center

NCT04386317

ACTIVE NOT RECRUITING Phase 2 15 participants

Terazosin and Parkinson's Disease Extension Study

Cedars-Sinai Medical Center

NCT05109364

ACTIVE NOT RECRUITING Phase 2 15 participants

Adrenergic Blockers for Cardiac Changes in Early Parkinson's Disease (Protocol 53136)

Michele Tagliati, MD

NCT03775096

COMPLETED Phase 1 82 participants

Quantitative Mapping of Substantia Nigra Iron in Parkinson's Disease (Stages I-IV, REM Sleep Behavior Disorder) and Controls

Weill Medical College of Cornell University

NCT03675282

COMPLETED Phase 4 24 participants

Treatment of REM Sleep Behavior Disorder (RBD) With Sodium Oxybate

Stanford University

NCT04006925

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 4
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the REM Sleep Behavior Disorder Trial Landscape

12 indexed REM Sleep Behavior Disorder studies · 6 recruiting (50%).

Phase mix: 1 late (III/IV) vs 5 early (I/II).

Top sponsor: Cedars-Sinai Medical Center (3 trials), 8 others listed. 12 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for REM Sleep Behavior Disorder?

PlainTrial tracks 12 US clinical trials for REM Sleep Behavior Disorder, of which 6 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for REM Sleep Behavior Disorder?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.