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NCT05471960 · ClinicalTrials.gov registry record · NA

Neuroplasticity in RBD

A NA study of REM Sleep Behavior Disorder, sponsored by University of Minnesota.

Recruiting
Registry status
NA
Development phase
86
Enrollment target
1
Study location

NCT05471960: Recruiting NA study of REM Sleep Behavior Disorder, sponsored by University of Minnesota.

NCT05471960 is a NA study of REM Sleep Behavior Disorder that is actively recruiting participants, run by University of Minnesota. The registered enrollment target is 86 participants, below the 150-participant average among 11 other REM Sleep Behavior Disorder trials with a reported enrollment target (43% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT05471960, a NA study of REM Sleep Behavior Disorder, is actively recruiting participants, sponsored by University of Minnesota.

RECRUITING
Registry status
NA
Development phase
86 participants
Enrollment target
1
Study location

Study Summary

REM sleep behavior disorder is a parasomnia that reflects the presence of alpha-synucleinopathy in the brain and is highly predictive of eventual phenoconversion to Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy over the course of years to decades. Neuroplastic adaptations in the brain during the prodromal stage of disease are thought to mask the expression of motor and non-motor signs and may substantially delay diagnosis during a potentially critical time window. This study will examine the state and progression (over 30 to 36 months) of neuroplastic changes in the excitability of the motor and prefrontal cortex (using transcranial magnetic stimulation), the structural and functional connectivity of the brain (using highfield, 7T, magnetic resonance imaging), and the relationship of these changes to the expression of motor and neuropsychological signs, in a cohort of individuals with REM sleep behavior disorder and matched controls.

Primary Outcome

Yes/No whether a change was observed from baseline

Conditions Studied

REM Sleep Behavior Disorder

Interventions

  • OTHER Natural progression over time

Study Locations (1)

Minnesota

  • University of Minnesota - Minneapolis

Trial Details

FieldValue
Enrollment Target 86 participants
Start Date 2022-08-01
Est. Completion 2030-08-01
Phase NA
University of Minnesota

966 total trials

What NCT05471960 shows while recruiting

NCT05471960 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 86 participants, a relatively small participant target, below the 150-participant average among 11 other REM Sleep Behavior Disorder trials with a reported enrollment target (43% lower).

The record links to 1 condition, with REM Sleep Behavior Disorder appearing as the primary indexed condition, and to 1 intervention - of which Natural progression over time is the first listed.

NCT05471960 reports a single indexed study location in Minnesota.

Frequently Asked Questions

What is clinical trial NCT05471960 about?

NCT05471960 is a clinical study titled "Neuroplasticity in RBD". REM sleep behavior disorder is a parasomnia that reflects the presence of alpha-synucleinopathy in the brain and is highly predictive of eventual phenoconversion to Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy over the course of years to decades. Neuroplastic adaptation...

What is the current status of trial NCT05471960?

This trial is currently recruiting. It is a NA study. The enrollment target is 86 participants. The study started on 2022-08-01. Estimated completion is 2030-08-01.

What conditions does trial NCT05471960 study?

This clinical trial studies the following conditions: REM Sleep Behavior Disorder.

What interventions are being tested in trial NCT05471960?

The interventions under investigation include: Natural progression over time (OTHER).

Who is sponsoring clinical trial NCT05471960?

This trial is sponsored by University of Minnesota, which has 966 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05471960 being conducted?

This trial has 1 study location across Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for REM Sleep Behavior Disorder

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT05471960's enrollment target sits among peer trials

86 4th of 11 higher than 8 of 11 other REM Sleep Behavior Disorder trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other REM Sleep Behavior Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT05471960

Source: ClinicalTrials.gov NCT05471960, the US trial registry maintained by the National Library of Medicine. NCT05471960 (small enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.