Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 7 recruiting now later-stage tilt

Relapsing Multiple Sclerosis: later-stage trial registry

7 of 24 indexed Relapsing Multiple Sclerosis trials are currently recruiting, with more weight in Phase 3-4.

Corpus placement: #686 of 28,707 conditions by registered trial count.

24 US clinical trials · 7 currently recruiting · #686 of 28,707 conditions by registered trial count

Relapsing Multiple Sclerosis: 24 US clinical trials tracked, 7 recruiting.

Relapsing Multiple Sclerosis is the subject of 24 registered US clinical trials on ClinicalTrials.gov, 7 of them currently open to new participants. 17 are in Phase 3-4 (later-stage) and 3 in Phase 1-2 (earlier-stage). The most active sponsor is Novartis Pharmaceuticals, running 6 of these trials.

Enrollment posture brief

Registry condition relapsing-multiple-sclerosis

OPEN 7 | RECR 29% | LATE 17 | EARLY 3 | RANK #686 | SPON 6

Nearest open-share peer: Bleeding (29% recruiting · 24 trials)

Aplastic Anemia37.5%Behavior37.5%Relapsing Multiple Scler (th…29%Allergic Rhinitis8.3%Adult Acute Myeloid Leukemia0%
Open-enrollment share among volume-matched conditions near Relapsing Multiple Sclerosis

Relapsing Multiple Sclerosis lists 7 open slots (29% of 24 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Relapsing Multiple Sclerosis on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Relapsing Multiple Sclerosis is recruiting below its size-band peers.

    7 of 24 indexed trials (29.2%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates Relapsing Multiple Sclerosis research.

    Novartis Pharmaceuticals accounts for 6 of 24 trials (25%). 13 distinct sponsors appear on at least one study for this condition label.

  3. Typical Relapsing Multiple Sclerosis enrolment sits around 500 participants.

    Median target enrolment is 500 among the 24 trials that report a genuine target (sentinel values excluded). 4 of those (16.7%) plan for fewer than 100 participants.

  4. Relapsing Multiple Sclerosis research is mostly interventional.

    20 interventional and 4 observational studies make up this index (83.3% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 23Phase 314Phase 43

Open and recent trials

24 total, page 1 of 1

RECRUITING Phase 3 800 participants

Study to Evaluate Safety, Efficacy and Pharmacokinetics (PK) of a Modified Regimen of Ublituximab

TG Therapeutics

NCT05877963

RECRUITING 500 participants

A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)

TG Therapeutics

NCT06433752

RECRUITING Phase 3 360 participants

Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.

Novartis Pharmaceuticals

NCT06846281

RECRUITING Phase 3 175 participants

Comparative PK, PD, Efficacy, and Safety Assessment of the Proposed Ocrelizumab Biosimilar CYB704 and Ocrevus in Participants With Relapsing Multiple Sclerosis

Sandoz

NCT06847724

RECRUITING Phase 3 156 participants

Best Available Therapy Versus Autologous Hematopoietic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS)

National Institute of Allergy and Infectious Diseases (NIAID)

NCT04047628

RECRUITING Phase 4 100 participants

Prospective Evaluation of Sequencing From antiCD-20 Therapies to Ozanimod

University of Colorado, Denver

NCT06529406

RECRUITING 16 participants

A Study Evaluating the Presence and Concentration of BRIUMVI™ (Ublituximab) in Breast Milk

TG Therapeutics

NCT06143514

ACTIVE NOT RECRUITING Phase 3 2,500 participants

A Study to Investigate Long-term Safety and Tolerability of Tolebrutinib in Participants With Multiple Sclerosis.

Sanofi

NCT06372145

ACTIVE NOT RECRUITING Phase 3 1,882 participants

Long-term Safety, Tolerability and Effectiveness Study of Ofatumumab in Patients With Relapsing MS

Novartis Pharmaceuticals

NCT03650114

ACTIVE NOT RECRUITING Phase 3 1,011 participants

Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS)

Novartis Pharmaceuticals

NCT05156281

ACTIVE NOT RECRUITING Phase 3 1,001 participants

Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS)

Novartis Pharmaceuticals

NCT05147220

ACTIVE NOT RECRUITING Phase 3 751 participants

Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)

Hoffmann-La Roche

NCT04586023

ACTIVE NOT RECRUITING Phase 3 746 participants

A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)

Hoffmann-La Roche

NCT04586010

ACTIVE NOT RECRUITING Phase 2 109 participants

A Study to Investigate the Efficacy of Fenebrutinib in Relapsing Multiple Sclerosis (RMS)

Hoffmann-La Roche

NCT05119569

ACTIVE NOT RECRUITING Phase 2 93 participants

A Study of Obexelimab in Patients With Relapsing Multiple Sclerosis (MoonStone)

Zenas BioPharma (USA)

NCT06564311

ACTIVE NOT RECRUITING Phase 4 60 participants

Effects of Ocrevus in Relapsing Multiple Sclerosis

Georgia State University

NCT04387734

ACTIVE NOT RECRUITING Phase 4 30 participants

Impact of Ocrelizumab on Cerebrospinal Fluid Biomarkers at Multiple Sclerosis Onset

University of California, San Francisco

NCT04466150

COMPLETED 35,895 participants

JC Virus Antibody Study of Participants With Relapsing Forms of MS Receiving Treatment With Natalizumab

Biogen

NCT01070836

COMPLETED Phase 3 1,516 participants

Efficacy and Safety Study of Peginterferon Beta-1a in Participants With Relapsing Multiple Sclerosis

Biogen

NCT00906399

COMPLETED Phase 3 1,077 participants

Long-Term Safety and Efficacy Study of Peginterferon Beta-1a

Biogen

NCT01332019

COMPLETED Phase 3 562 participants

An Open-label Study Evaluating Ofatumumab Treatment Effectiveness and PROs in Subjects With RMS Transitioning From Fumarate-based RMS Approved Therapies or Fingolimod to Ofatumumab

Novartis Pharmaceuticals

NCT04353492

COMPLETED Phase 2 258 participants

Efficacy and Safety Study of Ozanimod (RPC1063) in Relapsing Multiple Sclerosis Patients

Celgene

NCT01628393

COMPLETED Phase 3 185 participants

Safety and Tolerability of Conversion From Oral, Injectable, or Infusion Disease Modifying Therapies to Dose-titrated Oral Siponimod (Mayzent) in Advancing RMS Patients

Novartis Pharmaceuticals

NCT03623243

COMPLETED 113 participants

A Study to Assess the Effectiveness and Safety of Mayzent in Chinese Patients With Relapsing Forms of Multiple Sclerosis

Novartis

NCT06395909

Phase Distribution

PhaseTrial count
Phase 2 3
Phase 3 14
Phase 4 3

Top Sponsors

Biogen 3 trials
TG Therapeutics 3 trials
Novartis 1 trials
Sandoz 1 trials
Celgene 1 trials
Sanofi 1 trials

Named interventions

Most-linked intervention names on Relapsing Multiple Sclerosis records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Placebo Drug
8 trials
Teriflunomide Drug
5 trials
Fenebrutinib Drug
3 trials
Ocrelizumab Drug
3 trials
Ofatumumab Biological
2 trials
Remibrutinib Drug
2 trials
Ozanimod Drug
2 trials
natalizumab Drug
1 trials

US sites by state

Facility locations filed on Relapsing Multiple Sclerosis trials. A trial with sites in several states counts in each.

California 17 trials
Florida 14 trials
Arizona 12 trials
Colorado 11 trials
Ohio 9 trials
Alabama 9 trials
Maryland 6 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Relapsing Multiple Sclerosis page

24 registered trials, 7 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

  • 7 Relapsing Multiple Sclerosis trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
  • Novartis Pharmaceuticals sponsors the most Relapsing Multiple Sclerosis trials on record, review their full trial history before evaluating a specific study. See Novartis Pharmaceuticals's trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Relapsing Multiple Sclerosis condition card totals 24 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.