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ClinicalTrials.gov 7 recruiting now official registry

Relapsing Multiple Sclerosis clinical trials

Every US clinical trial registered for Relapsing Multiple Sclerosis — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

24 US clinical trials · 7 currently recruiting

The research picture

Relapsing Multiple Sclerosis has 24 registered US clinical trials, 7 of them open to new participants right now — about 29% of the total.

7
recruiting participants now
29%
of trials open to enrollment
17
in Phase 3–4 (later-stage)
6
top sponsor: Novartis Pharmaceuticals

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING Phase 3 800 participants

Study to Evaluate Safety, Efficacy and Pharmacokinetics (PK) of a Modified Regimen of Ublituximab

TG Therapeutics

NCT05877963

RECRUITING 500 participants

A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)

TG Therapeutics

NCT06433752

RECRUITING Phase 3 360 participants

Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.

Novartis Pharmaceuticals

NCT06846281

RECRUITING Phase 3 175 participants

Comparative PK, PD, Efficacy, and Safety Assessment of the Proposed Ocrelizumab Biosimilar CYB704 and Ocrevus in Participants With Relapsing Multiple Sclerosis

Sandoz

NCT06847724

RECRUITING Phase 3 156 participants

Best Available Therapy Versus Autologous Hematopoietic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS)

National Institute of Allergy and Infectious Diseases (NIAID)

NCT04047628

RECRUITING Phase 4 100 participants

Prospective Evaluation of Sequencing From antiCD-20 Therapies to Ozanimod

University of Colorado, Denver

NCT06529406

RECRUITING 16 participants

A Study Evaluating the Presence and Concentration of BRIUMVI™ (Ublituximab) in Breast Milk

TG Therapeutics

NCT06143514

ACTIVE NOT RECRUITING Phase 3 2,500 participants

A Study to Investigate Long-term Safety and Tolerability of Tolebrutinib in Participants With Multiple Sclerosis.

Sanofi

NCT06372145

ACTIVE NOT RECRUITING Phase 3 1,882 participants

Long-term Safety, Tolerability and Effectiveness Study of Ofatumumab in Patients With Relapsing MS

Novartis Pharmaceuticals

NCT03650114

ACTIVE NOT RECRUITING Phase 3 1,011 participants

Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS)

Novartis Pharmaceuticals

NCT05156281

ACTIVE NOT RECRUITING Phase 3 1,001 participants

Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS)

Novartis Pharmaceuticals

NCT05147220

ACTIVE NOT RECRUITING Phase 3 751 participants

Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)

Hoffmann-La Roche

NCT04586023

ACTIVE NOT RECRUITING Phase 3 746 participants

A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)

Hoffmann-La Roche

NCT04586010

ACTIVE NOT RECRUITING Phase 2 109 participants

A Study to Investigate the Efficacy of Fenebrutinib in Relapsing Multiple Sclerosis (RMS)

Hoffmann-La Roche

NCT05119569

ACTIVE NOT RECRUITING Phase 2 93 participants

A Study of Obexelimab in Patients With Relapsing Multiple Sclerosis (MoonStone)

Zenas BioPharma (USA)

NCT06564311

ACTIVE NOT RECRUITING Phase 4 60 participants

Effects of Ocrevus in Relapsing Multiple Sclerosis

Georgia State University

NCT04387734

ACTIVE NOT RECRUITING Phase 4 30 participants

Impact of Ocrelizumab on Cerebrospinal Fluid Biomarkers at Multiple Sclerosis Onset

University of California, San Francis

NCT04466150

COMPLETED 35,895 participants

JC Virus Antibody Study of Participants With Relapsing Forms of MS Receiving Treatment With Natalizumab

Biogen

NCT01070836

COMPLETED Phase 3 1,516 participants

Efficacy and Safety Study of Peginterferon Beta-1a in Participants With Relapsing Multiple Sclerosis

Biogen

NCT00906399

COMPLETED Phase 3 1,077 participants

Long-Term Safety and Efficacy Study of Peginterferon Beta-1a

Biogen

NCT01332019

COMPLETED Phase 3 562 participants

An Open-label Study Evaluating Ofatumumab Treatment Effectiveness and PROs in Subjects With RMS Transitioning From Fumarate-based RMS Approved Therapies or Fingolimod to Ofatumumab

Novartis Pharmaceuticals

NCT04353492

COMPLETED Phase 2 258 participants

Efficacy and Safety Study of Ozanimod (RPC1063) in Relapsing Multiple Sclerosis Patients

Celgene

NCT01628393

COMPLETED Phase 3 185 participants

Safety and Tolerability of Conversion From Oral, Injectable, or Infusion Disease Modifying Therapies to Dose-titrated Oral Siponimod (Mayzent) in Advancing RMS Patients

Novartis Pharmaceuticals

NCT03623243

COMPLETED 113 participants

A Study to Assess the Effectiveness and Safety of Mayzent in Chinese Patients With Relapsing Forms of Multiple Sclerosis

Novartis

NCT06395909

Phase Distribution

PhaseTrial count
Phase 2 3
Phase 3 14
Phase 4 3

Top Sponsors

Biogen 3 trials
TG Therapeutics 3 trials
Novartis 1 trials
Sandoz 1 trials
Celgene 1 trials
Sanofi 1 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Relapsing Multiple Sclerosis Trial Landscape

ClinicalTrials.gov lists 24 US studies indexed under Relapsing Multiple Sclerosis, and 7 of those are currently open to recruitment — roughly 29% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Relapsing Multiple Sclerosis shows 17 late-stage studies (Phase 3 and Phase 4 combined) alongside 3 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Relapsing Multiple Sclerosis is led by Novartis Pharmaceuticals with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 24 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Relapsing Multiple Sclerosis?

PlainTrial tracks 24 US clinical trials for Relapsing Multiple Sclerosis, of which 7 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Relapsing Multiple Sclerosis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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