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ClinicalTrials.gov 4 recruiting now official registry

Refractory Plasma Cell Myeloma clinical trials

4 of 26 indexed Refractory Plasma Cell Myeloma trials are currently recruiting.

26 US clinical trials · 4 currently recruiting

Refractory Plasma Cell Myeloma is the subject of 26 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 25 in Phase 1-2 (earlier-stage). The most active sponsor is Fred Hutchinson Cancer Center, running 5 of these trials.

The research picture

Refractory Plasma Cell Myeloma has 26 registered US clinical trials, 4 of them open to new participants right now, about 15% of the total.

4
recruiting participants now
15%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
5
top sponsor: Fred Hutchinson Cancer Center
Phase 114Phase 211

Active & Recent Trials

26 total, page 1 of 1

RECRUITING NA 175 participants

Non-chemotherapeutic Interventions for the Improvement of Quality of Life and Immune Function in Patients With Multiple Myeloma

Roswell Park Cancer Institute

NCT05312255

RECRUITING Phase 1 30 participants

CS1-CAR T Therapy Following Chemotherapy in Treating Patients With Relapsed or Refractory CS1 Positive Multiple Myeloma

City of Hope Medical Center

NCT03710421

RECRUITING Phase 2 29 participants

Leflunomide, Pomalidomide, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma

City of Hope Medical Center

NCT04508790

RECRUITING Phase 1 15 participants

Radioimmunotherapy (111Indium/225Actinium-DOTA-daratumumab) for the Treatment of Relapsed/Refractory Multiple Myeloma

City of Hope Medical Center

NCT05363111

ACTIVE NOT RECRUITING Phase 2 52 participants

Selinexor, Daratumumab, Carfilzomib and Dexamethasone for the Treatment of High-Risk, Recurrent or Refractory Multiple Myeloma

Academic and Community Cancer Research United

NCT04756401

ACTIVE NOT RECRUITING Phase 2 40 participants

Daratumumab, Bortezomib, and Dexamethasone Followed by Daratumumab, Ixazomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma

M.D. Anderson Cancer Center

NCT03763162

ACTIVE NOT RECRUITING Phase 1 22 participants

Low-Dose Selinexor and Choline Salicylate for Non-Hodgkin or Hodgkin Lymphoma, Histiocytic/Dendritic Cell Neoplasm, or Relapsed or Refractory Multiple Myeloma

Mayo Clinic

NCT04640779

ACTIVE NOT RECRUITING Phase 1 10 participants

Bortezomib and Pembrolizumab With or Without Pelareorep for the Treatment of Relapsed or Refractory Multiple Myeloma, AMBUSH Trial

University of Southern California

NCT05514990

ACTIVE NOT RECRUITING Phase 1 7 participants

Venetoclax and Tocilizumab for the Treatment of Patients With Relapsed or Refractory t(11;14) Multiple Myeloma

Emory University

NCT05391750

ACTIVE NOT RECRUITING Phase 1 5 participants

Genetically Engineered Cells (MUC1-Activated T-Cells) for the Treatment of MUC1 Positive Recurrent or Refractory Multiple Myeloma

Mayo Clinic

NCT05411497

ACTIVE NOT RECRUITING Phase 2 5 participants

Isatuximab, Carfilzomib, and Pomalidomide for the Treatment of Relapsed or Refractory Multiple Myeloma

OHSU Knight Cancer Institute

NCT04850599

COMPLETED Phase 2 210 participants

Tacrolimus and Mycophenolate Mofetil With or Without Sirolimus in Preventing Acute Graft-Versus-Host Disease in Patients Who Are Undergoing Donor Stem Cell Transplant for Hematologic Cancer

Fred Hutchinson Cancer Center

NCT00105001

COMPLETED Phase 2 143 participants

S1304, Carfilzomib and Dexamethasone for Treating Patients With Relapsed or Refractory Myeloma

SWOG Cancer Research Network

NCT01903811

COMPLETED Phase 2 70 participants

Ixazomib and Dexamethasone Versus Ixazomib, Dexamethasone and Lenalidomide, Randomized With NFKB2 Rearrangement

Emory University

NCT02765854

COMPLETED Phase 1 63 participants

Panobinostat and Carfilzomib in Treating Participants With Relapsed or Refractory Multiple Myeloma

M.D. Anderson Cancer Center

NCT01301807

COMPLETED Phase 1 50 participants

Vismodegib After Stem Cell Transplant in Treating Patients With High-Risk First Remission or Relapsed Multiple Myeloma

National Cancer Institute (NCI)

NCT01330173

COMPLETED Phase 1 50 participants

Carfilzomib and Melphalan Before Stem Cell Transplant in Treating Patients With Multiple Myeloma

Mayo Clinic

NCT01842308

COMPLETED Phase 2 32 participants

Lenalidomide, Dexamethasone, and Clarithromycin in Treating Patients Who Have Undergone Stem Cell Transplant for Multiple Myeloma

Fred Hutchinson Cancer Center

NCT00445692

COMPLETED Phase 1 32 participants

Ixazomib Plus Pomalidomide and Dexamethasone in Treating Patients With Relapsed or Relapsed/Refractory Multiple Myeloma

City of Hope Medical Center

NCT02119468

COMPLETED Phase 2 32 participants

Autologous or Syngeneic Stem Cell Transplant Followed by Donor Stem Cell Transplant and Bortezomib in Treating Patients With Newly Diagnosed High-Risk, Relapsed, or Refractory Multiple Myeloma

Fred Hutchinson Cancer Center

NCT00793572

COMPLETED Phase 1 28 participants

Immunotherapy With BCMA CAR-T Cells in Treating Patients With BCMA Positive Relapsed or Refractory Multiple Myeloma

Fred Hutchinson Cancer Center

NCT03338972

COMPLETED Phase 2 19 participants

Busulfan, Melphalan, and Bortezomib Before First-Line Stem Cell Transplant in Treating Patients With Multiple Myeloma

Albert Einstein College of Medicine

NCT01605032

COMPLETED Phase 1 18 participants

Bortezomib, Total Marrow Irradiation, Fludarabine Phosphate, and Melphalan in Treating Patients Undergoing Donor Peripheral Blood Stem Cell Transplant For High-Risk Stage I or II Multiple Myeloma

City of Hope Medical Center

NCT01163357

COMPLETED Phase 1 15 participants

90 Y-BC8-DOTA Monoclonal Antibody, Fludarabine Phosphate, and Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Multiple Myeloma

Fred Hutchinson Cancer Center

NCT01503242

COMPLETED Phase 1 12 participants

Viral Therapy in Treating Patients With Relapsed or Refractory Multiple Myeloma

National Cancer Institute (NCI)

NCT01533194

COMPLETED Phase 2 8 participants

Ixazomib Citrate, Pomalidomide, Dexamethasone, Stem Cell Transplant in Treating Relapsed or Refractory Multiple Myeloma

Mayo Clinic

NCT03202628

Phase Distribution

PhaseTrial count
Phase 1 14
Phase 2 11

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Refractory Plasma Cell Myeloma Trial Landscape

26 indexed Refractory Plasma Cell Myeloma studies · 4 recruiting (15%).

Phase mix: 0 late (III/IV) vs 25 early (I/II).

Top sponsor: Fred Hutchinson Cancer Center (5 trials), 9 others listed. 26 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Refractory Plasma Cell Myeloma?

PlainTrial tracks 26 US clinical trials for Refractory Plasma Cell Myeloma, of which 4 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Refractory Plasma Cell Myeloma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.