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NCT05312255 · ClinicalTrials.gov registry record · NA
Non-chemotherapeutic Interventions for the Improvement of Quality of Life and Immune Function in Patients With Multiple Myeloma
A NA study of Plasma Cell Myeloma and Refractory Plasma Cell Myeloma, sponsored by Roswell Park Cancer Institute.
- Recruiting
- Registry status
- NA
- Development phase
- 175
- Enrollment target
- 1
- Study location
NCT05312255: Recruiting NA study of Plasma Cell Myeloma and Refractory Plasma Cell Myeloma, sponsored by Roswell Park Cancer Institute.
NCT05312255 is a NA study of Plasma Cell Myeloma and Refractory Plasma Cell Myeloma that is actively recruiting participants, run by Roswell Park Cancer Institute. The registered enrollment target is 175 participants, below the 203-participant average among 32 other Plasma Cell Myeloma trials with a reported enrollment target (14% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05312255, a NA study of Plasma Cell Myeloma and Refractory Plasma Cell Myeloma, is actively recruiting participants, sponsored by Roswell Park Cancer Institute.
- RECRUITING
- Registry status
- NA
- Development phase
- 175 participants
- Enrollment target
- 1
- Study location
Study Summary
This clinical trial investigates the effect of non-chemotherapeutic interventions in patients with multiple myeloma or MDS. Non-chemotherapeutic interventions such as physical activity and nutritional interventions (e.g., modifications in diet) have been shown to positively affect the immune system and improve overall quality of life. Another purpose of this study is for researchers to learn how the addition of a beta-blocker (propranolol) to the standard treatment regimen in patients with newly diagnosed multiple myeloma affects immune response and quality of life. A study from the Mayo Clinic looked at multiple myeloma patients who were on a beta-blocker while undergoing chemotherapy and found that the use of a beta-blocker resulted in improved patient survival outcomes. Non-chemotherapeutic treatment options may help decrease symptoms and improve quality of life for patients with multiple myeloma.
Primary Outcome
Will be assessed by flow cytometry, comparing levels before and after one of three lifestyle interventions (physical exercise, intermittent fasting, beta blocker therapy). Will use a linear mixed model. Since the form of the model is unknown a priori, the power calculations are based on comparing any two timepoints using a two-sided paired t-test. With n=100, we have 80% power (at alpha = 0.05/3) to detect a difference of at least 0.33 standard deviations (SD).
Conditions Studied
Interventions
- OTHER Quality-of-Life Assessment
- OTHER Questionnaire Administration
- BEHAVIORAL Behavioral Intervention
- DRUG Propranolol
- DRUG Beta-Adrenergic Antagonist
Study Locations (1)
New York
- Roswell Park Cancer Institute - Buffalo
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 175 participants |
| Start Date | 2022-06-28 |
| Est. Completion | 2027-06-28 |
| Phase | NA |
What NCT05312255 shows while recruiting
NCT05312255 is an interventional study that assigns participants to a tested intervention. The registered 175 participants enrollment target is mid-sized for trials with a published cap, below the 203-participant average among 32 other Plasma Cell Myeloma trials with a reported enrollment target (14% lower).
The record links to 4 conditions, with Plasma Cell Myeloma appearing as the primary indexed condition, and to 5 interventions - of which Quality-of-Life Assessment is the first listed.
NCT05312255 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT05312255 about?
NCT05312255 is a clinical study titled "Non-chemotherapeutic Interventions for the Improvement of Quality of Life and Immune Function in Patients With Multiple Myeloma". This clinical trial investigates the effect of non-chemotherapeutic interventions in patients with multiple myeloma or MDS. Non-chemotherapeutic interventions such as physical activity and nutritional interventions (e.g., modifications in diet) have been shown to positively affect the immune system ...
What is the current status of trial NCT05312255?
This trial is currently recruiting. It is a NA study. The enrollment target is 175 participants. The study started on 2022-06-28. Estimated completion is 2027-06-28.
What conditions does trial NCT05312255 study?
This clinical trial studies the following conditions: Plasma Cell Myeloma, Refractory Plasma Cell Myeloma, Recurrent Plasma Cell Myeloma, Smoldering Plasma Cell Myeloma.
What interventions are being tested in trial NCT05312255?
The interventions under investigation include: Quality-of-Life Assessment (OTHER), Questionnaire Administration (OTHER), Behavioral Intervention (BEHAVIORAL), Propranolol (DRUG), Beta-Adrenergic Antagonist (DRUG).
Who is sponsoring clinical trial NCT05312255?
This trial is sponsored by Roswell Park Cancer Institute, which has 365 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05312255 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Plasma Cell Myeloma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05312255's enrollment target sits among peer trials
175 9th of 32 higher than 24 of 32 other Plasma Cell Myeloma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Plasma Cell Myeloma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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