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ClinicalTrials.gov 1 recruiting now early-phase tilt small index

Recurrent Non-small Cell Lung Cancer: early-phase trial registry

1 of 16 indexed Recurrent Non-small Cell Lung Cancer trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #1,060 of 28,707 conditions by registered trial count.

16 US clinical trials · 1 currently recruiting · #1,060 of 28,707 conditions by registered trial count

Recurrent Non-small Cell Lung Cancer: 16 US clinical trials tracked, 1 recruiting.

Recurrent Non-small Cell Lung Cancer is the subject of 16 registered US clinical trials on ClinicalTrials.gov, 1 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 13 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 10 of these trials.

Enrollment posture brief

Registry condition recurrent-non-small-cell-lung-cancer

OPEN 1 | RECR 6% | LATE 0 | EARLY 13 | RANK #1060 | SPON 10

Nearest open-share peer: Stage IV Pancreatic Cancer (6% recruiting · 16 trials)

Adolescent62.5%Alcohol Intoxication56.3%AL Amyloidosis43.8%Allergy18.8%Recurrent Non-small Cell (th…6%
Open-enrollment share among volume-matched conditions near Recurrent Non-small Cell Lung Cancer

Recurrent Non-small Cell Lung Cancer lists 1 open slots (6% of 16 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Recurrent Non-small Cell Lung Cancer on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Recurrent Non-small Cell Lung Cancer is recruiting below its size-band peers.

    1 of 16 indexed trials (6.3%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates Recurrent Non-small Cell Lung Cancer research.

    National Cancer Institute (NCI) accounts for 10 of 16 trials (62.5%). 7 distinct sponsors appear on at least one study for this condition label.

  3. Most Recurrent Non-small Cell Lung Cancer trials plan to enrol fewer than 100 people.

    Median target enrolment is 50 among the 16 trials that report a genuine target (sentinel values excluded). 12 of those (75%) plan for fewer than 100 participants.

  4. Recurrent Non-small Cell Lung Cancer research is mostly interventional.

    16 interventional and 0 observational studies make up this index (100% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 15Phase 28

Open and recent trials

16 total, page 1 of 1

RECRUITING NA 1,020 participants

Comprehensive Genomic Analysis in Tissue Samples From Patients With Recurrent or Stage IV Non-small Cell Lung Cancer

Barbara Ann Karmanos Cancer Institute

NCT02178163

ACTIVE NOT RECRUITING Phase 2 468 participants

A Study of Relatlimab Plus Nivolumab in Combination With Chemotherapy vs. Nivolumab in Combination With Chemotherapy as First Line Treatment for Participants With Stage IV or Recurrent Non-small Cell Lung Cancer (NSCLC)

Bristol-Myers Squibb

NCT04623775

ACTIVE NOT RECRUITING NA 29 participants

Image-Guided Hypofractionated Radiation Therapy With Stereotactic Body Radiation Therapy Boost and Combination Chemotherapy in Treating Patients With Stage II-III Non-Small Cell Lung Cancer That Cannot Be Removed By Surgery

Jonsson Comprehensive Cancer Center

NCT01345851

ACTIVE NOT RECRUITING Phase 1 13 participants

Clinical Trial of CD40L-Augmented TIL for Patients With EGFR, ALK, ROS1 or HER2-Driven NSCLC

H. Lee Moffitt Cancer Center and Research Institute

NCT05681780

COMPLETED NA 129 participants

Erlotinib in Treating Patients With Stage IIIB, Stage IV, or Recurrent Non-Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT00085280

COMPLETED Phase 2 120 participants

APRiCOT-L: Study to Evaluate Efficacy and Safety of Apricoxib With Erlotinib in Patients With Non-small Cell Lung Cancer

Tragara Pharmaceuticals

NCT00652340

COMPLETED Phase 2 80 participants

Erlotinib and Celecoxib in Treating Patients With Stage IIIB or Stage IV Recurrent Non-Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT00062101

COMPLETED Phase 2 65 participants

S0341: Erlotinib in Treating Patients With Advanced Primary Non-Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT00087412

COMPLETED Phase 2 60 participants

AZD2171 and Pemetrexed Disodium in Treating Patients With Relapsed Non-Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT00410904

COMPLETED Phase 2 50 participants

CCI-779 in Treating Patients With Stage IIIB (With Pleural Effusion) or Stage IV Non-Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT00079235

COMPLETED Phase 2 48 participants

A Phase II Trial of Triapine (NSC #663249) in Combination With Gemcitabine as Second Line Treatment of Non-Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT00077350

COMPLETED Phase 2 42 participants

Bortezomib in Treating Patients With Stage IIIB or Stage IV Lung Cancer

National Cancer Institute (NCI)

NCT00118144

COMPLETED Phase 1 34 participants

Bortezomib Plus Gemcitabine and Carboplatin in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT00052338

COMPLETED Phase 1 18 participants

Interleukin-12, Paclitaxel, and Trastuzumab in Treating Patients With Solid Tumors

National Cancer Institute (NCI)

NCT00028535

COMPLETED Phase 1 18 participants

Erlotinib Hydrochloride With or Without Cixutumumab in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT00778167

COMPLETED Early Phase 1 10 participants

Stereotactic Body Radiation Therapy After Surgery in Treating Patients With Stage III-IV Non-small Cell Lung Cancer

Roswell Park Cancer Institute

NCT01781741

Phase Distribution

PhaseTrial count
Phase 1 5
Phase 2 8

Named interventions

Most-linked intervention names on Recurrent Non-small Cell Lung Cancer records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

laboratory biomarker analysis Other
9 trials
erlotinib hydrochloride Drug
4 trials
gemcitabine hydrochloride Drug
2 trials
bortezomib Drug
2 trials
paclitaxel Drug
2 trials
carboplatin Drug
2 trials
cixutumumab Biological
1 trials
erlotinib/placebo Drug
1 trials

US sites by state

Facility locations filed on Recurrent Non-small Cell Lung Cancer trials. A trial with sites in several states counts in each.

California 5 trials
New York 3 trials
Michigan 3 trials
Florida 3 trials
Ohio 2 trials
Massachusetts 2 trials
Kentucky 2 trials
Illinois 2 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Recurrent Non-small Cell Lung Cancer page

16 registered trials, 1 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Recurrent Non-small Cell Lung Cancer condition card totals 16 registered trials; most-linked intervention laboratory biomarker analysis; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.