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ClinicalTrials.gov 12 recruiting now official registry

Rectal Adenocarcinoma clinical trials

Every US clinical trial registered for Rectal Adenocarcinoma — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

18 US clinical trials · 12 currently recruiting

The research picture

Rectal Adenocarcinoma has 18 registered US clinical trials, 12 of them open to new participants right now — about 67% of the total.

12
recruiting participants now
67%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
3
top sponsor: M.D. Anderson Cancer Center

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING Phase 3 477 participants

A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)

Merck Sharp & Dohme

NCT06997497

RECRUITING Phase 2 200 participants

Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid Tumors

Memorial Sloan Kettering Cancer Center

NCT04165772

RECRUITING Early Phase 1 120 participants

Active Surveillance and Chemotherapy Before Surgery in Treating Participants With Stage II-III Rectal Cancer

M.D. Anderson Cancer Center

NCT03594630

RECRUITING Phase 2 60 participants

Trial Utilizing Metronidazole to Optimize the Microbiome of Rectal Adenocarcinoma Undergoing Neoadjuvant Therapy

M.D. Anderson Cancer Center

NCT06569368

RECRUITING 50 participants

Establishing a ctDNA Biomarker to Improve Organ Preserving Strategies in Patients With Rectal Cancer

OHSU Knight Cancer Institute

NCT05081024

RECRUITING Phase 2 44 participants

Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates

University of Colorado, Denver

NCT07292298

RECRUITING 39 participants

Monitoring Treatment Response With On-board DWI During Neo-adjuvant Chemo-radiation for Rectal Cancer Using Magnetic Resonance-guided-radiotherapy Systems

Institut Paoli-Calmettes

NCT03961776

RECRUITING Phase 2 37 participants

A Study of Tucatinib and Trastuzumab in People With Rectal Cancer

Memorial Sloan Kettering Cancer Center

NCT05672524

RECRUITING Phase 2 26 participants

FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before Surgery

City of Hope Medical Center

NCT06780787

RECRUITING Phase 1 25 participants

Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer

Jonsson Comprehensive Cancer Center

NCT04703101

RECRUITING Phase 1 22 participants

MRI-Guided Adaptive Radiation Therapy for Organ Preservation in Rectal Cancer

Medical College of Wisconsin

NCT04808323

RECRUITING Phase 3 20 participants

Evaluating Novel Therapies in ctDNA Positive GI Cancers

Georgetown University

NCT05482516

ACTIVE NOT RECRUITING 818 participants

Young-Onset Colorectal Cancer

M.D. Anderson Cancer Center

NCT02863107

ACTIVE NOT RECRUITING Phase 2 50 participants

ExIST Study of LY2157299 (Galunisertib) in Rectal Cancer

Providence Health & Services

NCT02688712

ACTIVE NOT RECRUITING Phase 2 48 participants

Study of Cabozantinib and Nivolumab in Refractory Metastatic Microsatellite Stable (MSS) Colorectal Cancer

University of Colorado, Denver

NCT04963283

ACTIVE NOT RECRUITING Early Phase 1 20 participants

Adaptive Radiation for Locally Advanced Rectal Adenocarcinoma

H. Lee Moffitt Cancer Center and Research Institute

NCT05108428

ACTIVE NOT RECRUITING Phase 1 19 participants

TAS-102 With Concurrent Radiation for the Treatment of Untreated Resectable Stage II-III Rectal Cancer

OHSU Knight Cancer Institute

NCT04104139

COMPLETED Phase 1 42 participants

Nintedanib and Capecitabine in Treating Patients With Refractory Metastatic Colorectal Cancer

Roswell Park Cancer Institute

NCT02393755

Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 7
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Rectal Adenocarcinoma Trial Landscape

ClinicalTrials.gov lists 18 US studies indexed under Rectal Adenocarcinoma, and 12 of those are currently open to recruitment — roughly 67% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Rectal Adenocarcinoma shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 13 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Rectal Adenocarcinoma is led by M.D. Anderson Cancer Center with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 18 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Rectal Adenocarcinoma?

PlainTrial tracks 18 US clinical trials for Rectal Adenocarcinoma, of which 12 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Rectal Adenocarcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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