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NCT05108428 · ClinicalTrials.gov registry record · Early Phase 1
Adaptive Radiation for Locally Advanced Rectal Adenocarcinoma
A Early Phase 1 study of Rectal Adenocarcinoma, sponsored by H. Lee Moffitt Cancer Center and Research Institute.
- Active
- Registry status
- Early Phase 1
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT05108428: Active Early Phase 1 study of Rectal Adenocarcinoma, sponsored by H. Lee Moffitt Cancer Center and Research Institute.
NCT05108428 is a Early Phase 1 study of Rectal Adenocarcinoma that is active but no longer recruiting, run by H. Lee Moffitt Cancer Center and Research Institute. The registered enrollment target is 20 participants, below the 123-participant average among 17 other Rectal Adenocarcinoma trials with a reported enrollment target (84% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05108428, a Early Phase 1 study of Rectal Adenocarcinoma, is active but no longer recruiting, sponsored by H. Lee Moffitt Cancer Center and Research Institute.
- ACTIVE NOT RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of the study is to determine the feasibility of using magnetic resonance imaging (MRI)-guided adaptive chemoradiation therapy to improve response to treatment.
Primary Outcome
Investigators will demonstrate if MRI guided dose-adaptation based on MR morphologic objective measurements during primary chemoradiation is feasible. Feasibility will be recorded for each patient as an indicator variable (1=feasible; 0=not feasible)
Conditions Studied
Interventions
- DRUG Capecitabine
- RADIATION Radiation Therapy
- DRUG FOLFOX regimen
Study Locations (1)
Florida
- Moffitt Cancer Center - Tampa
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2021-12-23 |
| Est. Completion | 2026-10 |
| Phase | Early Phase 1 |
What the registry record for NCT05108428 still lists
NCT05108428 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 123-participant average among 17 other Rectal Adenocarcinoma trials with a reported enrollment target (84% lower).
The record links to 1 condition, with Rectal Adenocarcinoma appearing as the primary indexed condition, and to 3 interventions - of which Capecitabine is the first listed.
NCT05108428 reports a single indexed study location in Florida.
Frequently Asked Questions
What is clinical trial NCT05108428 about?
NCT05108428 is a clinical study titled "Adaptive Radiation for Locally Advanced Rectal Adenocarcinoma". The purpose of the study is to determine the feasibility of using magnetic resonance imaging (MRI)-guided adaptive chemoradiation therapy to improve response to treatment.
What is the current status of trial NCT05108428?
This trial is currently active not recruiting. It is a Early Phase 1 study. The enrollment target is 20 participants. The study started on 2021-12-23. Estimated completion is 2026-10.
What conditions does trial NCT05108428 study?
This clinical trial studies the following conditions: Rectal Adenocarcinoma.
What interventions are being tested in trial NCT05108428?
The interventions under investigation include: Capecitabine (DRUG), Radiation Therapy (RADIATION), FOLFOX regimen (DRUG).
Who is sponsoring clinical trial NCT05108428?
This trial is sponsored by H. Lee Moffitt Cancer Center and Research Institute, which has 502 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05108428 being conducted?
This trial has 1 study location across Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Rectal Adenocarcinoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05108428's enrollment target sits among peer trials
20 16th of 17 higher than 1 of 17 other Rectal Adenocarcinoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Rectal Adenocarcinoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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