Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
PrEP clinical trials
4 of 6 indexed PrEP trials are currently recruiting.
Corpus placement: #2,866 of 28,707 conditions by registered trial count.
6 US clinical trials · 4 currently recruiting · #2,866 of 28,707 conditions by registered trial count
PrEP: 6 US clinical trials tracked, 4 recruiting.
PrEP is the subject of 6 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. The most active sponsor is Johns Hopkins Bloomberg School of Public Health, running 1 of these trials.
Enrollment posture brief
Registry condition prep
OPEN 4 | RECR 67% | LATE 0 | EARLY 0 | RANK #2866 | SPON 1
Volume-matched condition peers
Nearest open-share peer: Adenocarcinoma of Lung (67% recruiting · 6 trials)
PrEP lists 4 open slots (67% of 6 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for PrEP on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
-
PrEP is recruiting above its size-band peers.
4 of 6 indexed trials (66.7%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
-
One sponsor concentrates PrEP research.
Johns Hopkins Bloomberg School of Public Health accounts for 1 of 6 trials (16.7%). 6 distinct sponsors appear on at least one study for this condition label.
-
Typical PrEP enrolment sits around 1,000 participants.
Median target enrolment is 1,000 among the 6 trials that report a genuine target (sentinel values excluded). 1 of those (16.7%) plan for fewer than 100 participants.
-
PrEP research is mostly interventional.
5 interventional and 1 observational studies make up this index (83.3% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
6 total, page 1 of 1
HOTSPOT Study: Implement and Evaluate the PrEP (Pre-exposure Prophylaxis) Implementation Strategy
University of Texas Southwestern Medical Center
NCT06919419
Using PrEP, Doing It for Ourselves
Duke University
NCT06638892
A Multi-Level Trauma-Informed Approach to Increase HIV Pre-exposure Prophylaxis Initiation Among Black Women
Johns Hopkins Bloomberg School of Public Health
NCT06703060
PrOTECT AL: PrEP Optimization Through Enhanced Continuum Tracking
University of Alabama at Birmingham
NCT07231640
Clinic-based HIV Identification and Prevention Project Using Electronic Resources
Johns Hopkins University
NCT05412433
Hepatitis C Treatment to Prevent HIV, Initiate Opioid Substitution Therapy, and Reduce Risky Behavior
University of Maryland, Baltimore
NCT03221309
Phase Distribution
Phase data not available
Top Sponsors
Named interventions
Most-linked intervention names on PrEP records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on PrEP trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this PrEP page
6 registered trials, 4 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 4 PrEP trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Johns Hopkins Bloomberg School of Public Health sponsors the most PrEP trials on record, review their full trial history before evaluating a specific study. See Johns Hopkins Bloomberg School of Public Health's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This PrEP condition card totals 6 registered trials; most-linked intervention Multilevel; top US site state Maryland. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.