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ClinicalTrials.gov 9 recruiting now official registry

Persistent Atrial Fibrillation clinical trials

Every US clinical trial registered for Persistent Atrial Fibrillation — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

16 US clinical trials · 9 currently recruiting

The research picture

Persistent Atrial Fibrillation has 16 registered US clinical trials, 9 of them open to new participants right now — about 56% of the total.

9
recruiting participants now
56%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
3
top sponsor: Vivek Reddy

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 15,000 participants

Real-world Experience of Catheter Ablation for the Treatment of Paroxysmal and Persistent Atrial Fibrillation

Heart Rhythm Clinical and Research Solutions

NCT04088071

RECRUITING NA 407 participants

Repeat Ablation of Persistent Atrial Fibrillation, Including Mitral Isthmus Catheter Ablation, With the FARAPULSE Pulsed Field Ablation System

Boston Scientific Corporation

NCT06735534

RECRUITING Phase 4 275 participants

Pragmatic Evaluation of a Pentaspline Pulsed Field Ablation System to Treat Atrial Fibrillation and Related Arrhythmias

Vivek Reddy

NCT06765356

RECRUITING NA 250 participants

ULTRA-HFIB-Redo: Ultrasound-based Renal Sympathetic Denervation vs Control in Redo Ablation Patients

Vivek Reddy

NCT05988411

RECRUITING NA 245 participants

Endocardial Mapping With the CoreMap EP Mapping System

CoreMap

NCT06529978

RECRUITING 200 participants

SPHERE Per-AF Post-Approval Study

Medtronic Cardiac Ablation Solutions

NCT06858306

RECRUITING 200 participants

Observational Study to Examine the Procedural and Outcomes of AF Ablation Assisted by STAR Apollo™ Mapping System

Kansas City Heart Rhythm Research Foundation

NCT05826665

RECRUITING NA 160 participants

Medtronic Terminate AF Study

Medtronic Cardiac Surgery

NCT03546374

RECRUITING NA 60 participants

ARIADNE Clinical Trial

Stavros E Mountantonakis

NCT06747091

ACTIVE NOT RECRUITING NA 549 participants

Safety and Effectiveness of the Globe® Pulsed Field System for Treating Patients With Symptomatic Paroxysmal or Persistent Atrial Fibrillation

Kardium

NCT05462145

ACTIVE NOT RECRUITING NA 484 participants

Pulsed Field Ablation (PFA) vs Anti-Arrhythmic Drug (AAD) Therapy as a First Line Treatment for Persistent Atrial Fibrillation

Boston Scientific Corporation

NCT06096337

ACTIVE NOT RECRUITING 400 participants

STOP Persistent AF PAS

Medtronic Cardiac Ablation Solutions

NCT05005949

ACTIVE NOT RECRUITING NA 150 participants

AtriCure CryoICE Lesions for Persistent and Long-standing Persistent Atrial Fibrillation Treatment

AtriCure

NCT03732794

COMPLETED NA 350 participants

Randomized Evaluation of Atrial Fibrillation Treatment With Focal Impulse and Rotor Modulation Guided Procedures

Abbott Medical Devices

NCT02274857

COMPLETED NA 110 participants

Comparison of Pulmonary Vein Ablation With or Without Left Atrial Posterior Wall Ablation for Persistent AF (PIVoTAL)

Arash Aryana, MD

NCT03057548

COMPLETED NA 65 participants

RADAR Clinical Trial

Vivek Reddy

NCT03263702

Phase Distribution

PhaseTrial count
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Persistent Atrial Fibrillation Trial Landscape

ClinicalTrials.gov lists 16 US studies indexed under Persistent Atrial Fibrillation, and 9 of those are currently open to recruitment — roughly 56% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Persistent Atrial Fibrillation shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 0 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Persistent Atrial Fibrillation is led by Vivek Reddy with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 16 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Persistent Atrial Fibrillation?

PlainTrial tracks 16 US clinical trials for Persistent Atrial Fibrillation, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Persistent Atrial Fibrillation?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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