Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 8 recruiting now official registry

Periodontal Diseases clinical trials

Every US clinical trial registered for Periodontal Diseases — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

16 US clinical trials · 8 currently recruiting

The research picture

Periodontal Diseases has 16 registered US clinical trials, 8 of them open to new participants right now — about 50% of the total.

8
recruiting participants now
50%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
2
top sponsor: The Forsyth Institute

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING NA 929 participants

Oral Health Intervention in Adult Primary Care

Case Western Reserve University

NCT06555029

RECRUITING Phase 3 150 participants

Shaping the Indications for Periodontal Adjunctive Antibiotics in Dental Practice

Rutgers, The State University of New Jersey

NCT06131021

RECRUITING 100 participants

Oral Health In Cirrhosis of the Liver (ORACLE)

Hunter Holmes Mcguire Veteran Affairs Medical Center

NCT06052150

RECRUITING NA 100 participants

F.L.O.S.S. Project (Facilitated Lessons on Oral and Systemic Health in Survivors)

Georgetown University

NCT06315855

RECRUITING NA 76 participants

Novel Dental Gel as an Adjunct to Scaling and Root Planing

University of Alabama at Birmingham

NCT05384132

RECRUITING NA 70 participants

An Evaluation of the Effect of the Erchonia FX-405 Laser as an Adjunctive Treatment of Periodontitis

Erchonia Corporation

NCT06656325

RECRUITING NA 25 participants

Microsurgery and Periodontal Healing

The University of Texas Health Science Center at San Antonio

NCT07054008

RECRUITING 12 participants

Changes in Microbial Status From Dentate, Edentulous and After Dental Implant Placement

Case Western Reserve University

NCT06149585

ACTIVE NOT RECRUITING NA 250 participants

Addition of Dehydrated Human Amnion-Chorion Membrane During Scaling and Root Planing

University of Colorado, Denver

NCT03836378

COMPLETED Phase 2 400 participants

Study Comparing Two Different Methods of Treating Periodontal Disease

The Forsyth Institute

NCT00127244

COMPLETED Phase 2 154 participants

Microbial Associations in Periodontal Health and Disease

The Forsyth Institute

NCT00066001

COMPLETED NA 58 participants

Impact of Brief Motivational Interviewing on Periodontal Clinical Outcomes: a 3-year Post-trial Follow-up

University of Minnesota

NCT05336396

COMPLETED NA 30 participants

Evaluating the Efficacy of a Gum Health Formulation on Teeth Whitening in Patients With Gingivitis and Periodontitis

Glo Science

NCT02906982

COMPLETED NA 29 participants

Treatment of Periodontitis With Er:YAG Laser

Columbia University

NCT03628872

COMPLETED NA 21 participants

Application of L-PRF in Periodontal Surgery

The University of Texas Health Science Center at San Antonio

NCT06296498

COMPLETED NA 20 participants

Clinical and Microbiologic Outcomes of Adjunctive Antimicrobial Photodynamic Therapy in the Non-surgical and Surgical Treatment of Teeth With Periodontal Disease

The University of Texas Health Science Center, Houston

NCT05252000

Phase Distribution

PhaseTrial count
Phase 2 2
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Periodontal Diseases Trial Landscape

ClinicalTrials.gov lists 16 US studies indexed under Periodontal Diseases, and 8 of those are currently open to recruitment — roughly 50% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Periodontal Diseases shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 2 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Periodontal Diseases is led by The Forsyth Institute with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 16 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Periodontal Diseases?

PlainTrial tracks 16 US clinical trials for Periodontal Diseases, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Periodontal Diseases?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →