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Overdose clinical trials
Every US clinical trial registered for Overdose — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
14 US clinical trials · 4 currently recruiting
The research picture
Overdose has 14 registered US clinical trials, 4 of them open to new participants right now — about 29% of the total.
- 4
- recruiting participants now
- 29%
- of trials open to enrollment
- 1
- in Phase 3–4 (later-stage)
- 2
- top sponsor: Kaiser Permanente
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Emergency Medicine Peer Outreach Worker Engagement for Recovery
University of California, Los Angeles
NCT06320015
Community-based Education, Navigation, and Support Intervention for Military Veterans
New York University
NCT05343169
Shelter HArm Reduction Evaluation
NYU Langone Health
NCT07170072
A Universal Primary Care Based Intervention to Reduce Youth Overdose Risk
Boston Medical Center
NCT07022717
The Impact of a Web-Based Naloxone Intervention Under Standing Orders to Patients Prescribed Chronic Opioid Therapy
Kaiser Permanente
NCT03337009
Motivational Interviewing to Increase Uptake of Drug Checking and Safe Drug Use Behaviors to Reduce Overdose
University of California, San Diego
NCT06855836
Pharmacist-Led Interventions to Increase Access to Medications for Opioid Use Disorders (PLI-MOUD)
University of Arkansas
NCT05776823
The Ganchero Intervention for Migrant People Who Inject Drugs From Puerto Rico in New York City
North Jersey AIDS Alliance dba North Jersey Community Research Initiative (NJCRI)
NCT06316739
Improving Access to Naloxone to Prevent Opioid Overdose Deaths (SAIA-Naloxone)
RTI International
NCT05886712
Evaluation of a Medication Health Center to Promote Opioid Safety
Kaiser Permanente
NCT06456294
Monitoring of Overdose Patients With and Without Supplemental Oxygen in the Emergency Department
Hennepin Healthcare Research Institute
NCT02101424
Project POINT: Effectiveness and Scalability of an Overdose Survivor Intervention
Indiana University
NCT03336268
Rapid Initiation of Drug Treatment Engagement
University of Pennsylvania
NCT03908437
AWAITS: A Web-based E-health Application for Active Illicit Opioid Users
University of Cincinnati
NCT03402672
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Overdose Trial Landscape
ClinicalTrials.gov lists 14 US studies indexed under Overdose, and 4 of those are currently open to recruitment — roughly 29% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Overdose shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 0 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Overdose is led by Kaiser Permanente with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 14 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Overdose?
PlainTrial tracks 14 US clinical trials for Overdose, of which 4 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Overdose?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.