Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Opioid-induced Constipation: later-stage trial registry
1 of 6 indexed Opioid-induced Constipation trials are currently recruiting, with more weight in Phase 3-4.
Corpus placement: #2,866 of 28,707 conditions by registered trial count.
6 US clinical trials · 1 currently recruiting · #2,866 of 28,707 conditions by registered trial count
Opioid-induced Constipation: 6 US clinical trials tracked, 1 recruiting.
Opioid-induced Constipation is the subject of 6 registered US clinical trials on ClinicalTrials.gov, 1 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most active sponsor is Bausch Health Americas, running 3 of these trials.
Enrollment posture brief
Registry condition opioid-induced-constipation
OPEN 1 | RECR 17% | LATE 3 | EARLY 1 | RANK #2866 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Acute Renal Failure (17% recruiting · 6 trials)
Opioid-induced Constipation lists 1 open slots (17% of 6 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Opioid-induced Constipation on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Opioid-induced Constipation is recruiting below its size-band peers.
1 of 6 indexed trials (16.7%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Opioid-induced Constipation research.
Bausch Health Americas accounts for 3 of 6 trials (50%). 4 distinct sponsors appear on at least one study for this condition label.
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Typical Opioid-induced Constipation enrolment sits around 547 participants.
Median target enrolment is 547 among the 6 trials that report a genuine target (sentinel values excluded). 2 of those (33.3%) plan for fewer than 100 participants.
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Opioid-induced Constipation research is mostly interventional.
5 interventional and 1 observational studies make up this index (83.3% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
6 total, page 1 of 1
Risk of Major Adverse Cardiovascular Events for Naldemedine & Other Medications for Opioid Induced Constipation
BioDelivery Sciences International
NCT03720613
A Study of Oral Methylnaltrexone (MNTX) for the Treatment of Opioid-Induced Constipation (OIC) in Participants With Chronic, Non-Malignant Pain
Bausch Health Americas
NCT01186770
Efficacy and Safety of Naldemedine in the Treatment of Opioid-induced Constipation
Shionogi
NCT01965158
Safety of Subcutaneous Methylnaltrexone for Opioid-Induced Constipation in Patients With Advanced Illness
Bausch Health Americas
NCT00672139
A Study of TD-1211 in Subjects With Opioid-Induced Constipation (OIC)
Theravance Biopharma
NCT01401985
Compassionate Use Study of Methylnaltrexone
Bausch Health Americas
NCT01368562
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 1 |
| Phase 3 | 2 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Opioid-induced Constipation records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Opioid-induced Constipation trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Opioid-induced Constipation page
6 registered trials, 1 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 1 Opioid-induced Constipation trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Bausch Health Americas sponsors the most Opioid-induced Constipation trials on record, review their full trial history before evaluating a specific study. See Bausch Health Americas's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Opioid-induced Constipation condition card totals 6 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.