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ClinicalTrials.gov 6 recruiting now official registry

Muscular Atrophy, Spinal clinical trials

6 of 16 indexed Muscular Atrophy, Spinal trials are currently recruiting.

16 US clinical trials · 6 currently recruiting

Muscular Atrophy, Spinal is the subject of 16 registered US clinical trials on ClinicalTrials.gov, 6 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 7 in Phase 1-2 (earlier-stage). The most active sponsor is Hoffmann-La Roche, running 7 of these trials.

The research picture

Muscular Atrophy, Spinal has 16 registered US clinical trials, 6 of them open to new participants right now, about 38% of the total.

6
recruiting participants now
38%
of trials open to enrollment
6
in Phase 3–4 (later-stage)
7
top sponsor: Hoffmann-La Roche
Phase 13Phase 24Phase 34Phase 42

Active & Recent Trials

16 total, page 1 of 1

RECRUITING Phase 1 58 participants

A Study to Find Out How Nusinersen is Processed in the Body When Given Through the ThecaFlex DRx™ System in Adult and Pediatric Participants With Spinal Muscular Atrophy (PIERRE-PK)

Biogen

NCT06555419

RECRUITING Phase 3 30 participants

A Study to Learn About Salanersen's (BIIB115) Effects on Movement and Its Safety When Given Before Symptoms Appear in Babies With Genetically Diagnosed Spinal Muscular Atrophy (SMA)

Biogen

NCT07221669

RECRUITING Phase 4 28 participants

A Study Evaluating the Effectiveness and Safety of Risdiplam Administered in Pediatric Patients With Spinal Muscular Atrophy Who Experienced a Plateau or Decline in Function After Gene Therapy

Hoffmann-La Roche

NCT05861999

RECRUITING Phase 4 28 participants

A Study Evaluating the Effectiveness and Safety of Risdiplam Administered as an Early Intervention in Pediatric Participants With Spinal Muscular Atrophy After Gene Therapy

Hoffmann-La Roche

NCT05861986

RECRUITING 20 participants

A Study to Learn How Nusinersen (Spinraza) Affects Participants With Spinal Muscular Atrophy (SMA) Who Took it Before or During Pregnancy And About The Health of Their Babies

Biogen

NCT05789758

RECRUITING Phase 2 10 participants

A Study to Investigate the Pharmacokinetics and Safety of Risdiplam in Infants With Spinal Muscular Atrophy

Hoffmann-La Roche

NCT05808764

ACTIVE NOT RECRUITING Phase 3 238 participants

Long-Term Safety & Efficacy of Apitegromab in Patients With SMA Who Completed Previous Trials of Apitegromab

Scholar Rock

NCT05626855

ACTIVE NOT RECRUITING Phase 3 115 participants

A Study to Learn About the Long-Term Safety of Higher Doses of Nusinersen (BIIB058) Given as Injections to Participants With Spinal Muscular Atrophy (SMA) Who Took Part in an Earlier Nusinersen Trial (ONWARD)

Biogen

NCT04729907

ACTIVE NOT RECRUITING Phase 2 26 participants

A Study of Risdiplam in Infants With Genetically Diagnosed and Presymptomatic Spinal Muscular Atrophy

Hoffmann-La Roche

NCT03779334

COMPLETED Phase 2 231 participants

A Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of Risdiplam (RO7034067) in Type 2 and 3 Spinal Muscular Atrophy (SMA) Participants

Hoffmann-La Roche

NCT02908685

COMPLETED Phase 3 188 participants

Efficacy and Safety of Apitegromab in Patients With Later-Onset Spinal Muscular Atrophy Treated With Nusinersen or Risdiplam

Scholar Rock

NCT05156320

COMPLETED Phase 2 58 participants

An Active Treatment Study of SRK-015 in Patients With Type 2 or Type 3 Spinal Muscular Atrophy

Scholar Rock

NCT03921528

COMPLETED 36 participants

A Study to Collect Blood Samples From Patients With Spinal Muscular Atrophy for Biomarker Analysis

Hoffmann-La Roche

NCT01910168

COMPLETED Phase 1 29 participants

A Pilot Therapeutic Trial Using Hydroxyurea in Type I Spinal Muscular Atrophy Patients

Stanford University

NCT00568698

COMPLETED Phase 1 26 participants

A Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics and Safety and Tolerability of a Single Oral Dose of Risdiplam Compared to Matched Healthy Participants With Normal Hepatic Function

Hoffmann-La Roche

NCT03920865

COMPLETED NA 12 participants

Progressive Strength Training in Spinal Muscular Atrophy

University of Utah

NCT01233817

Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 4
Phase 3 4
Phase 4 2

Top Sponsors

Biogen 4 trials
Scholar Rock 3 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Muscular Atrophy, Spinal Trial Landscape

16 indexed Muscular Atrophy, Spinal studies · 6 recruiting (38%).

Phase mix: 6 late (III/IV) vs 7 early (I/II).

Top sponsor: Hoffmann-La Roche (7 trials), 4 others listed. 16 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Muscular Atrophy, Spinal?

PlainTrial tracks 16 US clinical trials for Muscular Atrophy, Spinal, of which 6 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Muscular Atrophy, Spinal?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.