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ClinicalTrials.gov 4 recruiting now early-phase tilt small index

Metastatic Bladder Urothelial Carcinoma: early-phase trial registry

4 of 14 indexed Metastatic Bladder Urothelial Carcinoma trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #1,230 of 28,707 conditions by registered trial count.

14 US clinical trials · 4 currently recruiting · #1,230 of 28,707 conditions by registered trial count

Metastatic Bladder Urothelial Carcinoma: 14 US clinical trials tracked, 4 recruiting.

Metastatic Bladder Urothelial Carcinoma is the subject of 14 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 9 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 6 of these trials.

Enrollment posture brief

Registry condition metastatic-bladder-urothelial-carcinoma

OPEN 4 | RECR 29% | LATE 4 | EARLY 9 | RANK #1230 | SPON 6

Nearest open-share peer: Acne Scars (29% recruiting · 7 trials)

Acute Respiratory Failure35.7%Adherence, Medication35.7%Metastatic Bladder Uroth (th…29%Acromegaly28.6%Abscess7.1%
Open-enrollment share among volume-matched conditions near Metastatic Bladder Urothelial Carcinoma

Metastatic Bladder Urothelial Carcinoma lists 4 open slots (29% of 14 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Metastatic Bladder Urothelial Carcinoma on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Metastatic Bladder Urothelial Carcinoma is recruiting below its size-band peers.

    4 of 14 indexed trials (28.6%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates Metastatic Bladder Urothelial Carcinoma research.

    National Cancer Institute (NCI) accounts for 6 of 14 trials (42.9%). 7 distinct sponsors appear on at least one study for this condition label.

  3. Most Metastatic Bladder Urothelial Carcinoma trials plan to enrol fewer than 100 people.

    Median target enrolment is 70 among the 14 trials that report a genuine target (sentinel values excluded). 11 of those (78.6%) plan for fewer than 100 participants.

  4. Metastatic Bladder Urothelial Carcinoma research is mostly interventional.

    13 interventional and 1 observational studies make up this index (92.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 12Phase 27Phase 33Phase 41

Open and recent trials

14 total, page 1 of 1

RECRUITING 324 participants

Immune Checkpoint Inhibitor Response in Solid Tumors Using a Live Tumor Diagnostic Platform

Mayo Clinic

NCT06349642

RECRUITING Phase 4 75 participants

Enfortumab Vedotin and Pembrolizumab With Cystectomy and/or Ureterectomy for Locally Advanced or Metastatic Bladder and Upper Urothelial Tract Cancer, CAST-AI Trial

Mayo Clinic

NCT06764095

RECRUITING Phase 2 70 participants

Therapeutic Plasma Exchange With Enfortumab Vedotin and Pembrolizumab for Treatment of Bladder Cancers

Mayo Clinic

NCT07087860

RECRUITING Phase 2 64 participants

Pemetrexed Response in Relation to Tumor Alterations of Gene Status for the Treatment of Patients With Metastatic Urothelial Bladder Cancer and Other Solid Tumors

Northwestern University

NCT06630416

ACTIVE NOT RECRUITING Phase 3 654 participants

Testing the Addition of the Anti-cancer Drug, Cabozantinib, to the Usual Immunotherapy Treatment, Avelumab, in Patients With Metastatic Urothelial Cancer, MAIN-CAV Study

National Cancer Institute (NCI)

NCT05092958

ACTIVE NOT RECRUITING Phase 3 184 participants

Comparing the New Anti-cancer Drug Eribulin With Chemotherapy Against the Usual Chemotherapy Alone in Metastatic Urothelial Cancer

National Cancer Institute (NCI)

NCT04579224

ACTIVE NOT RECRUITING Phase 2 72 participants

Atezolizumab With or Without Eribulin Mesylate in Treating Patients With Recurrent Locally Advanced or Metastatic Urothelial Cancer

National Cancer Institute (NCI)

NCT03237780

ACTIVE NOT RECRUITING Phase 1 24 participants

Testing Combination Erdafitinib and Enfortumab Vedotin in Metastatic Bladder Cancer After Treatment With Chemotherapy and Immunotherapy

National Cancer Institute (NCI)

NCT04963153

ACTIVE NOT RECRUITING Phase 1 15 participants

Pembrolizumab With Combination Chemotherapy in Treating Participants With Locally Advanced or Metastatic Small Cell/Neuroendocrine Cancers of Urothelium or Prostate

Jonsson Comprehensive Cancer Center

NCT03582475

ACTIVE NOT RECRUITING Phase 2 6 participants

ARID1A and/or KDM6A Mutation and CXCL13 Expression

M.D. Anderson Cancer Center

NCT04953104

ACTIVE NOT RECRUITING Phase 2 6 participants

Immune Checkpoint Inhibitors With or Without Propranolol Hydrochloride In Patients With Urothelial Carcinoma

Emory University

NCT04848519

ACTIVE NOT RECRUITING Phase 3 3 participants

Trying to Find the Correct Length of Treatment With Immune Checkpoint Therapy

Alliance for Clinical Trials in Oncology

NCT04637594

COMPLETED Phase 2 87 participants

Cisplatin and Gemcitabine Hydrochloride With or Without Berzosertib in Treating Patients With Metastatic Urothelial Cancer

National Cancer Institute (NCI)

NCT02567409

COMPLETED Phase 2 47 participants

Atezolizumab and CYT107 in Treating Participants With Locally Advanced, Inoperable, or Metastatic Urothelial Carcinoma

National Cancer Institute (NCI)

NCT03513952

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 7
Phase 3 3
Phase 4 1

Named interventions

Most-linked intervention names on Metastatic Bladder Urothelial Carcinoma records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Biospecimen Collection Procedure
9 trials
Computed Tomography Procedure
7 trials
Avelumab Drug
3 trials
Bone Scan Procedure
3 trials
Enfortumab Vedotin Drug
3 trials
Atezolizumab Drug
3 trials
Eribulin Mesylate Drug
2 trials
Nivolumab Drug
2 trials

US sites by state

Facility locations filed on Metastatic Bladder Urothelial Carcinoma trials. A trial with sites in several states counts in each.

California 8 trials
Florida 5 trials
Arizona 5 trials
Minnesota 3 trials
Colorado 3 trials
Texas 2 trials
New York 2 trials
Missouri 2 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Metastatic Bladder Urothelial Carcinoma page

14 registered trials, 4 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

  • 4 Metastatic Bladder Urothelial Carcinoma trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
  • National Cancer Institute (NCI) sponsors the most Metastatic Bladder Urothelial Carcinoma trials on record, review their full trial history before evaluating a specific study. See National Cancer Institute (NCI)'s trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Metastatic Bladder Urothelial Carcinoma condition card totals 14 registered trials; most-linked intervention Biospecimen Collection; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.