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ClinicalTrials.gov 4 recruiting now official registry

Metastatic Bladder Urothelial Carcinoma clinical trials

4 of 14 indexed Metastatic Bladder Urothelial Carcinoma trials are currently recruiting.

14 US clinical trials · 4 currently recruiting

Metastatic Bladder Urothelial Carcinoma is the subject of 14 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 9 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 6 of these trials.

The research picture

Metastatic Bladder Urothelial Carcinoma has 14 registered US clinical trials, 4 of them open to new participants right now, about 29% of the total.

4
recruiting participants now
29%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
6
top sponsor: National Cancer Institute (NCI)
Phase 12Phase 27Phase 33Phase 41

Active & Recent Trials

14 total, page 1 of 1

RECRUITING 324 participants

Immune Checkpoint Inhibitor Response in Solid Tumors Using a Live Tumor Diagnostic Platform

Mayo Clinic

NCT06349642

RECRUITING Phase 4 75 participants

Enfortumab Vedotin and Pembrolizumab With Cystectomy and/or Ureterectomy for Locally Advanced or Metastatic Bladder and Upper Urothelial Tract Cancer, CAST-AI Trial

Mayo Clinic

NCT06764095

RECRUITING Phase 2 70 participants

Therapeutic Plasma Exchange With Enfortumab Vedotin and Pembrolizumab for Treatment of Bladder Cancers

Mayo Clinic

NCT07087860

RECRUITING Phase 2 64 participants

Pemetrexed Response in Relation to Tumor Alterations of Gene Status for the Treatment of Patients With Metastatic Urothelial Bladder Cancer and Other Solid Tumors

Northwestern University

NCT06630416

ACTIVE NOT RECRUITING Phase 3 654 participants

Testing the Addition of the Anti-cancer Drug, Cabozantinib, to the Usual Immunotherapy Treatment, Avelumab, in Patients With Metastatic Urothelial Cancer, MAIN-CAV Study

National Cancer Institute (NCI)

NCT05092958

ACTIVE NOT RECRUITING Phase 3 184 participants

Comparing the New Anti-cancer Drug Eribulin With Chemotherapy Against the Usual Chemotherapy Alone in Metastatic Urothelial Cancer

National Cancer Institute (NCI)

NCT04579224

ACTIVE NOT RECRUITING Phase 2 72 participants

Atezolizumab With or Without Eribulin Mesylate in Treating Patients With Recurrent Locally Advanced or Metastatic Urothelial Cancer

National Cancer Institute (NCI)

NCT03237780

ACTIVE NOT RECRUITING Phase 1 24 participants

Testing Combination Erdafitinib and Enfortumab Vedotin in Metastatic Bladder Cancer After Treatment With Chemotherapy and Immunotherapy

National Cancer Institute (NCI)

NCT04963153

ACTIVE NOT RECRUITING Phase 1 15 participants

Pembrolizumab With Combination Chemotherapy in Treating Participants With Locally Advanced or Metastatic Small Cell/Neuroendocrine Cancers of Urothelium or Prostate

Jonsson Comprehensive Cancer Center

NCT03582475

ACTIVE NOT RECRUITING Phase 2 6 participants

ARID1A and/or KDM6A Mutation and CXCL13 Expression

M.D. Anderson Cancer Center

NCT04953104

ACTIVE NOT RECRUITING Phase 2 6 participants

Immune Checkpoint Inhibitors With or Without Propranolol Hydrochloride In Patients With Urothelial Carcinoma

Emory University

NCT04848519

ACTIVE NOT RECRUITING Phase 3 3 participants

Trying to Find the Correct Length of Treatment With Immune Checkpoint Therapy

Alliance for Clinical Trials in Oncology

NCT04637594

COMPLETED Phase 2 87 participants

Cisplatin and Gemcitabine Hydrochloride With or Without Berzosertib in Treating Patients With Metastatic Urothelial Cancer

National Cancer Institute (NCI)

NCT02567409

COMPLETED Phase 2 47 participants

Atezolizumab and CYT107 in Treating Participants With Locally Advanced, Inoperable, or Metastatic Urothelial Carcinoma

National Cancer Institute (NCI)

NCT03513952

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 7
Phase 3 3
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metastatic Bladder Urothelial Carcinoma Trial Landscape

14 indexed Metastatic Bladder Urothelial Carcinoma studies · 4 recruiting (29%).

Phase mix: 4 late (III/IV) vs 9 early (I/II).

Top sponsor: National Cancer Institute (NCI) (6 trials), 6 others listed. 14 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metastatic Bladder Urothelial Carcinoma?

PlainTrial tracks 14 US clinical trials for Metastatic Bladder Urothelial Carcinoma, of which 4 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metastatic Bladder Urothelial Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.