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ClinicalTrials.gov 4 recruiting now early-phase tilt small index

Malignant Mesothelioma: early-phase trial registry

4 of 13 indexed Malignant Mesothelioma trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #1,315 of 28,707 conditions by registered trial count.

13 US clinical trials · 4 currently recruiting · #1,315 of 28,707 conditions by registered trial count

Malignant Mesothelioma: 13 US clinical trials tracked, 4 recruiting.

Malignant Mesothelioma is the subject of 13 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 11 in Phase 1-2 (earlier-stage). The most active sponsor is Alliance for Clinical Trials in Oncology, running 2 of these trials.

Enrollment posture brief

Registry condition malignant-mesothelioma

OPEN 4 | RECR 31% | LATE 2 | EARLY 11 | RANK #1315 | SPON 2

Nearest open-share peer: Acute Decompensated Heart Failure (31% recruiting · 13 trials)

ACL Injury61.5%Acute Biphenotypic Leukemia46.2%Malignant Mesothelioma (this)31%Accidental Falls30.8%Actinic Keratoses23.1%
Open-enrollment share among volume-matched conditions near Malignant Mesothelioma

Malignant Mesothelioma lists 4 open slots (31% of 13 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Malignant Mesothelioma on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Malignant Mesothelioma is recruiting below its size-band peers.

    4 of 13 indexed trials (30.8%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates Malignant Mesothelioma research.

    Alliance for Clinical Trials in Oncology accounts for 2 of 13 trials (15.4%). 10 distinct sponsors appear on at least one study for this condition label.

  3. Most Malignant Mesothelioma trials plan to enrol fewer than 100 people.

    Median target enrolment is 40 among the 12 trials that report a genuine target (sentinel values excluded). 10 of those (83.3%) plan for fewer than 100 participants.

  4. Malignant Mesothelioma research is mostly interventional.

    13 interventional and 0 observational studies make up this index (100% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 15Phase 26Phase 32

Open and recent trials

13 total, page 1 of 1

RECRUITING Phase 1 100 participants

Study of ISM6331 in Participants With Advanced/Metastatic Malignant Mesothelioma or Other Solid Tumors

InSilico Medicine Hong Kong Limited

NCT06566079

RECRUITING Phase 2 64 participants

A Study of Additional Chemotherapy After Surgery for People With Malignant Peritoneal Mesothelioma

Memorial Sloan Kettering Cancer Center

NCT06057935

RECRUITING Phase 2 55 participants

Brentuximab Vedotin in Treating Patients With CD30+ Malignant Mesothelioma That Cannot Be Removed by Surgery

M.D. Anderson Cancer Center

NCT03007030

RECRUITING Phase 1 10 participants

Fast TILs to Treat Metastatic Cancer Patients With Pleural Disease

David Bartlett, MD

NCT07192900

ACTIVE NOT RECRUITING Phase 1 9 participants

Light Dosimetry for Photodynamic Therapy With Porfimer Sodium in Treating Participants With Malignant Mesothelioma or Non-Small Cell Lung Cancer With Pleural Disease Undergoing Surgery

Roswell Park Cancer Institute

NCT03678350

COMPLETED Phase 3 405 participants

Early Palliative Care With Standard Care or Standard Care Alone in Improving Quality of Life of Patients With Incurable Lung or Non-colorectal Gastrointestinal Cancer and Their Family Caregivers

Alliance for Clinical Trials in Oncology

NCT02349412

COMPLETED Phase 2 69 participants

Gemcitabine and Epirubicin in Treating Patients With Malignant Mesothelioma

Alliance for Clinical Trials in Oncology

NCT00017186

COMPLETED Phase 2 40 participants

Cyclophosphamide Plus Vaccine Therapy in Treating Patients With Advanced Cancer

St. Vincent Medical Center - Los Angeles

NCT00002475

COMPLETED Phase 2 30 participants

Liposomal-Cisplatin Analogue (L-NDDP) in Treating Patients With Malignant Pleural Mesothelioma

NYU Langone Health

NCT00004033

COMPLETED Phase 2 30 participants

Radiofrequency Ablation in Treating Patients With Refractory or Advanced Lung Cancer

Jonsson Comprehensive Cancer Center

NCT00024076

COMPLETED Phase 1 20 participants

Vaccine Therapy in Treating Patients With Stage I, Stage II, or Stage IIIA Non-small Cell Lung Cancer or With Stage I or Stage II Mesothelioma

Roswell Park Cancer Institute

NCT00003974

COMPLETED Phase 1 6 participants

Cisplatin, Interferon Alfa, Surgery, and Radiation Therapy in Treating Patients With Malignant Pleural Mesothelioma

Fox Chase Cancer Center

NCT00003263

COMPLETED Phase 3

Cisplatin With or Without Pemetrexed Disodium in Treating Patients With Malignant Mesothelioma of the Pleura That Cannot be Removed by Surgery

Memorial Sloan Kettering Cancer Center

NCT00005636

Phase Distribution

PhaseTrial count
Phase 1 5
Phase 2 6
Phase 3 2

Named interventions

Most-linked intervention names on Malignant Mesothelioma records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

recombinant interferon alfa Biological
2 trials
cisplatin Drug
2 trials
radiofrequency ablation Procedure
1 trials
therapeutic thoracoscopy Procedure
1 trials
liposomal NDDP Drug
1 trials
surgical procedure Procedure
1 trials
DetoxPC Drug
1 trials
lung tumor associated antigen Biological
1 trials

US sites by state

Facility locations filed on Malignant Mesothelioma trials. A trial with sites in several states counts in each.

New York 6 trials
Pennsylvania 5 trials
Illinois 4 trials
Texas 3 trials
Ohio 3 trials
Michigan 3 trials
California 3 trials
Virginia 2 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Malignant Mesothelioma page

13 registered trials, 4 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Malignant Mesothelioma condition card totals 13 registered trials; most-linked intervention recombinant interferon alfa; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.