Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Major Depressive Episode: early-phase trial registry
6 of 8 indexed Major Depressive Episode trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #2,176 of 28,707 conditions by registered trial count.
8 US clinical trials · 6 currently recruiting · #2,176 of 28,707 conditions by registered trial count
Major Depressive Episode: 8 US clinical trials tracked, 6 recruiting.
Major Depressive Episode is the subject of 8 registered US clinical trials on ClinicalTrials.gov, 6 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is Brian Mickey, running 1 of these trials.
Enrollment posture brief
Registry condition major-depressive-episode
OPEN 6 | RECR 75% | LATE 0 | EARLY 2 | RANK #2176 | SPON 1
Volume-matched condition peers
Nearest open-share peer: Adolescent Idiopathic Scoliosis (75% recruiting · 8 trials)
Major Depressive Episode lists 6 open slots (75% of 8 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Major Depressive Episode on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Major Depressive Episode is recruiting above its size-band peers.
6 of 8 indexed trials (75%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Major Depressive Episode trials is spread across many organizations.
Brian Mickey accounts for 1 of 8 trials (12.5%). 8 distinct sponsors appear on at least one study for this condition label.
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Most Major Depressive Episode trials plan to enrol fewer than 100 people.
Median target enrolment is 80 among the 8 trials that report a genuine target (sentinel values excluded). 5 of those (62.5%) plan for fewer than 100 participants.
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Major Depressive Episode splits between interventional and observational designs.
5 interventional and 3 observational studies make up this index (62.5% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
8 total, page 1 of 1
University of Iowa Interventional Psychiatry Service Patient Registry
Mark Niciu
NCT04480918
Reward Processing and Depressive Subtypes: Identifying Neural Biotypes
San Francisco Veterans Affairs Medical Center
NCT06080646
Circuit-Based Approach to Suicide: Biomarkers, Predictors, and Novel Therapeutics
Massachusetts General Hospital
NCT04130958
Accelerated Intermittent Theta Burst in Treatment-Naive Adolescents
University of Texas at Austin
NCT06523439
Feasibility of Home-Based Intermittent 60Hz Light Therapy for Major Depressive Disorder (MDD)
NYU Langone Health
NCT07111390
Personalized Ultrasonic Brain Stimulation for Depression (R61)
Brian Mickey
NCT06902298
Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder
Brigham and Women's Hospital
NCT03336918
Personalized Ultrasonic Brain Stimulation for Depression
University of Utah
NCT05301036
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Major Depressive Episode records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Major Depressive Episode trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Major Depressive Episode page
8 registered trials, 6 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 6 Major Depressive Episode trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Brian Mickey sponsors the most Major Depressive Episode trials on record, review their full trial history before evaluating a specific study. See Brian Mickey's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Major Depressive Episode condition card totals 8 registered trials; most-linked intervention Diadem prototype; top US site state Utah. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.