Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Lyme Disease: full-pipeline trial registry
5 of 10 indexed Lyme Disease trials are currently recruiting.
Corpus placement: #1,724 of 28,707 conditions by registered trial count.
10 US clinical trials · 5 currently recruiting · #1,724 of 28,707 conditions by registered trial count
Lyme Disease: 10 US clinical trials tracked, 5 recruiting.
Lyme Disease is the subject of 10 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Allergy and Infectious Diseases (NIAID), running 4 of these trials.
Enrollment posture brief
Registry condition lyme-disease
OPEN 5 | RECR 50% | LATE 3 | EARLY 2 | RANK #1724 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Abdominal Aortic Aneurysms (50% recruiting · 6 trials)
Lyme Disease lists 5 open slots (50% of 10 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Lyme Disease on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Lyme Disease is recruiting above its size-band peers.
5 of 10 indexed trials (50%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Lyme Disease research.
National Institute of Allergy and Infectious Diseases (NIAID) accounts for 4 of 10 trials (40%). 6 distinct sponsors appear on at least one study for this condition label.
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Typical Lyme Disease enrolment sits around 500 participants.
Median target enrolment is 500 among the 10 trials that report a genuine target (sentinel values excluded). 5 of those (50%) plan for fewer than 100 participants.
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Lyme Disease splits between interventional and observational designs.
5 interventional and 5 observational studies make up this index (50% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
10 total, page 1 of 1
A Comprehensive Clinical, Microbiological and Immunological Assessment of Patients With Suspected Post Treatment Lyme Disease Syndrome and Selected Control Populations
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00001539
Evaluation, Treatment, and Follow-up of Patients With Lyme Disease
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00028080
Human Immune Response to Ixodes Scapularis Tick Bites
National Institute of Allergy and Infectious Diseases (NIAID)
NCT05036707
Pregnancy and Early Neurodevelopmental Outcomes Following In Utero Lyme Disease Exposure
Children's National Research Institute
NCT06026969
Navigating Pregnancy and Parenthood With Lyme Disease
Children's National Research Institute
NCT06397794
An Efficacy, Safety, Tolerability, Immunogenicity, and Lot-Consistency Clinical Trial of a 6-Valent OspA-Based Lyme Disease Vaccine (VLA15)
Pfizer
NCT05477524
Lyme Disease Prevention Program
Brigham and Women's Hospital
NCT00000432
ImmuneSense Lyme Study
Adaptive Biotechnologies
NCT04422314
Study and Treatment of Post Lyme Disease (STOP-LD)
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00000937
First Clinical Study of the Safety and Blood Levels of a Human Monoclonal Antibody (2217LS) Against Lyme Disease Bacteria in Healthy People
MassBiologics
NCT04863287
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 3 | 3 |
Top Sponsors
Named interventions
Most-linked intervention names on Lyme Disease records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Lyme Disease trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Lyme Disease page
10 registered trials, 5 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 5 Lyme Disease trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- National Institute of Allergy and Infectious Diseases (NIAID) sponsors the most Lyme Disease trials on record, review their full trial history before evaluating a specific study. See National Institute of Allergy and Infectious Diseases (NIAID)'s trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Lyme Disease condition card totals 10 registered trials; most-linked intervention 0.9% Sodium Chloride (NaCl); top US site state Maryland. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.