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Lyme Disease clinical trials
5 of 10 indexed Lyme Disease trials are currently recruiting.
10 US clinical trials · 5 currently recruiting
Lyme Disease is the subject of 10 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Allergy and Infectious Diseases (NIAID), running 4 of these trials.
The research picture
Lyme Disease has 10 registered US clinical trials, 5 of them open to new participants right now, about 50% of the total.
- 5
- recruiting participants now
- 50%
- of trials open to enrollment
- 3
- in Phase 3–4 (later-stage)
- 4
- top sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Active & Recent Trials
10 total, page 1 of 1
A Comprehensive Clinical, Microbiological and Immunological Assessment of Patients With Suspected Post Treatment Lyme Disease Syndrome and Selected Control Populations
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00001539
Evaluation, Treatment, and Follow-up of Patients With Lyme Disease
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00028080
Human Immune Response to Ixodes Scapularis Tick Bites
National Institute of Allergy and Infectious Diseases (NIAID)
NCT05036707
Pregnancy and Early Neurodevelopmental Outcomes Following In Utero Lyme Disease Exposure
Children's National Research Institute
NCT06026969
Navigating Pregnancy and Parenthood With Lyme Disease
Children's National Research Institute
NCT06397794
An Efficacy, Safety, Tolerability, Immunogenicity, and Lot-Consistency Clinical Trial of a 6-Valent OspA-Based Lyme Disease Vaccine (VLA15)
Pfizer
NCT05477524
Lyme Disease Prevention Program
Brigham and Women's Hospital
NCT00000432
ImmuneSense Lyme Study
Adaptive Biotechnologies
NCT04422314
Study and Treatment of Post Lyme Disease (STOP-LD)
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00000937
First Clinical Study of the Safety and Blood Levels of a Human Monoclonal Antibody (2217LS) Against Lyme Disease Bacteria in Healthy People
MassBiologics
NCT04863287
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 3 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Lyme Disease Trial Landscape
10 indexed Lyme Disease studies · 5 recruiting (50%).
Phase mix: 3 late (III/IV) vs 2 early (I/II).
Top sponsor: National Institute of Allergy and Infectious Diseases (NIAID) (4 trials), 5 others listed. 10 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Lyme Disease?
PlainTrial tracks 10 US clinical trials for Lyme Disease, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Lyme Disease?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.