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ClinicalTrials.gov 11 recruiting now official registry

Locally Advanced Pancreatic Adenocarcinoma clinical trials

11 of 19 indexed Locally Advanced Pancreatic Adenocarcinoma trials are currently recruiting.

19 US clinical trials · 11 currently recruiting

Locally Advanced Pancreatic Adenocarcinoma is the subject of 19 registered US clinical trials on ClinicalTrials.gov, 11 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 3 of these trials.

The research picture

Locally Advanced Pancreatic Adenocarcinoma has 19 registered US clinical trials, 11 of them open to new participants right now, about 58% of the total.

11
recruiting participants now
58%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
3
top sponsor: National Cancer Institute (NCI)
Phase 19Phase 26Phase 32

Active & Recent Trials

19 total, page 1 of 1

RECRUITING Phase 3 480 participants

The Effect of Kinisoquin™ on Thromboembolic Events in Patients With Metastatic or Locally Advanced Pancreatic Cancer

Quercis Pharma

NCT06861088

RECRUITING Phase 3 94 participants

Studying Chemotherapy With or Without Panitumumab for Unresectable, Locally Advanced, or Metastatic Pancreatic Cancer Without KRAS Mutations

SWOG Cancer Research Network

NCT06998940

RECRUITING Phase 1 92 participants

Testing the Addition of a New Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiotherapy in Patients With Locally Advanced Pancreatic Cancer

National Cancer Institute (NCI)

NCT04172532

RECRUITING Phase 2 64 participants

Neoadjuvant Chemotherapy for Borderline Resectable and Locally Advanced Pancreatic Adenocarcinoma

Wake Forest University Health Sciences

NCT05825066

RECRUITING Phase 2 52 participants

Evaluating NALIRIFOX vs Modified Gemcitabine, Nab-Paclitaxel and Cisplatin in Patients With Locally Advanced and Metastatic Pancreatic Adenocarcinoma

Medical University of South Carolina

NCT07076212

RECRUITING NA 48 participants

Stereotactic Body Radiation and Tumor Treating Fields for Locally Advanced Pancreas Cancer

Baptist Health South Florida

NCT05679674

RECRUITING Phase 1 36 participants

A Phase 1 Study to Evaluate Safety and Efficacy of XER-001 (Amifostine for Nasoduodenal Delivery) in Combination With Sterotactic Body Radiotherapy for Treatment in Patients With Locally Advanced Pancreatic Cancer.

Xerient Pharma

NCT07157033

RECRUITING Early Phase 1 30 participants

First-in-human Study of the Theranostic Pair [68Ga]Ga DOTA-5G and [177Lu]Lu DOTA-ABM-5G in Pancreatic Cancer

University of California, Davis

NCT04665947

RECRUITING Phase 1 26 participants

PTM-101 in Pancreatic Ductal Adenocarcinoma (PDAC)

PanTher Therapeutics

NCT06673017

RECRUITING Phase 2 25 participants

Photoradiation With Verteporfin to Facilitate Immunologic Activity of Pembrolizumab in Unresectable, Locally Advanced or Metastatic Pancreatic Cancer

Mayo Clinic

NCT06381154

RECRUITING Phase 2 25 participants

Acoustic Cluster Therapy (ACT) With Chemotherapy for the Treatment of Locally Advanced Pancreatic Cancer

EXACT Therapeutics AS

NCT06850623

ACTIVE NOT RECRUITING Phase 2 88 participants

Gemcitabine Hydrochloride and Cisplatin With or Without Veliparib or Veliparib Alone in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer

National Cancer Institute (NCI)

NCT01585805

ACTIVE NOT RECRUITING Phase 1 60 participants

Pressure Enabled Intrapancreatic Delivery of SD-101 With Checkpoint Blockade for Locally Advanced Pancreatic Adenocarcinoma

TriSalus Life Sciences

NCT05607953

ACTIVE NOT RECRUITING Phase 1 22 participants

BATs Treatment for Pancreatic Cancer, Phase Ib/II

University of Virginia

NCT03269526

ACTIVE NOT RECRUITING Phase 2 19 participants

Study of Paclitaxel Protein Bound + Gemcitabine + Cisplatin + Hydrochloroquine as Treatment in Untreated Pancreas Cancer

HonorHealth Research Institute

NCT04669197

ACTIVE NOT RECRUITING Phase 1 18 participants

Vaccine Therapy and Sargramostim in Treating Patients With Pancreas Cancer That Cannot Be Removed By Surgery

National Cancer Institute (NCI)

NCT00669734

ACTIVE NOT RECRUITING Phase 1 15 participants

Calaspargase Pegol-Mnkl and Cobimetinib for the Treatment of Locally Advanced or Metastatic Pancreatic Cancer

OHSU Knight Cancer Institute

NCT05034627

ACTIVE NOT RECRUITING NA 2 participants

PROACTIVE: Surgical Resection Outcomes in Locally Advanced and Unresectable Pancreatic Cancer After Neoadjuvant Chemotherapy

University of Southern California

NCT06132087

COMPLETED Phase 1 11 participants

Immunochemoradiotherapy in Patients With Pancreatic Cancer

Providence Health & Services

NCT01342224

Phase Distribution

PhaseTrial count
Phase 1 9
Phase 2 6
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Locally Advanced Pancreatic Adenocarcinoma Trial Landscape

19 indexed Locally Advanced Pancreatic Adenocarcinoma studies · 11 recruiting (58%).

Phase mix: 2 late (III/IV) vs 15 early (I/II).

Top sponsor: National Cancer Institute (NCI) (3 trials), 9 others listed. 19 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Locally Advanced Pancreatic Adenocarcinoma?

PlainTrial tracks 19 US clinical trials for Locally Advanced Pancreatic Adenocarcinoma, of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Locally Advanced Pancreatic Adenocarcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.