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ClinicalTrials.gov 5 recruiting now official registry

Locally Advanced Lung Non-Small Cell Carcinoma clinical trials

5 of 9 indexed Locally Advanced Lung Non-Small Cell Carcinoma trials are currently recruiting.

9 US clinical trials · 5 currently recruiting

Locally Advanced Lung Non-Small Cell Carcinoma is the subject of 9 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 3 of these trials.

The research picture

Locally Advanced Lung Non-Small Cell Carcinoma has 9 registered US clinical trials, 5 of them open to new participants right now, about 56% of the total.

5
recruiting participants now
56%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
3
top sponsor: M.D. Anderson Cancer Center
Phase 15Phase 21Phase 31

Active & Recent Trials

9 total, page 1 of 1

RECRUITING Phase 3 474 participants

Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer

NRG Oncology

NCT05624996

RECRUITING NA 100 participants

Cardiovascular Injury and Cardiac Fitness in Locally Advanced Non-Small Cell Lung Cancer Patients Receiving Model Based Personalized Chemoradiation

M.D. Anderson Cancer Center

NCT05010109

RECRUITING Phase 1 37 participants

Sotorasib in Combination With Trastuzumab Deruxtecan for the Treatment of Locally Advanced and Metastatic Non-small Cell Lung Cancer With a KRAS G12C Mutation

National Cancer Institute (NCI)

NCT07012031

RECRUITING NA 34 participants

Adaptive Radiation Planning for the Reduction of Radiation-Induced Toxicity in Patients With Stage II-IV Non-small Cell Lung Cancer

Rutgers, The State University of New Jersey

NCT04751747

RECRUITING Phase 1 28 participants

Papaverine in Combination With Chemoradiation for the Treatment of Stage II-III Non-small Cell Lung Cancer

Ohio State University Comprehensive Cancer Center

NCT05136846

ACTIVE NOT RECRUITING Phase 2 35 participants

Tocilizumab, Ipilimumab, and Nivolumab for the Treatment of Advanced Melanoma, Non-Small Cell Lung Cancer, or Urothelial Carcinoma

M.D. Anderson Cancer Center

NCT04940299

ACTIVE NOT RECRUITING Phase 1 21 participants

Ipilimumab and Nivolumab in Combination With Radiation Therapy in Treating Patients With Stage 2-3 Non-small Lung Cancer

M.D. Anderson Cancer Center

NCT04013542

ACTIVE NOT RECRUITING Phase 1 8 participants

Minnelide and Osimertinib for the Treatment of Advanced EGFR Mutated Non-Small Cell Lung Cancer

City of Hope Medical Center

NCT05166616

ACTIVE NOT RECRUITING Phase 1 5 participants

Brigatinib and Bevacizumab for the Treatment of ALK-Rearranged Locally Advanced, Metastatic, or Recurrent NSCLC

City of Hope Medical Center

NCT04227028

Phase Distribution

PhaseTrial count
Phase 1 5
Phase 2 1
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Locally Advanced Lung Non-Small Cell Carcinoma Trial Landscape

9 indexed Locally Advanced Lung Non-Small Cell Carcinoma studies · 5 recruiting (56%).

Phase mix: 1 late (III/IV) vs 6 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (3 trials), 5 others listed. 9 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Locally Advanced Lung Non-Small Cell Carcinoma?

PlainTrial tracks 9 US clinical trials for Locally Advanced Lung Non-Small Cell Carcinoma, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Locally Advanced Lung Non-Small Cell Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.