Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Langerhans Cell Histiocytosis: early-phase trial registry
5 of 9 indexed Langerhans Cell Histiocytosis trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #1,916 of 28,707 conditions by registered trial count.
9 US clinical trials · 5 currently recruiting · #1,916 of 28,707 conditions by registered trial count
Langerhans Cell Histiocytosis: 9 US clinical trials tracked, 5 recruiting.
Langerhans Cell Histiocytosis is the subject of 9 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 7 in Phase 1-2 (earlier-stage). The most active sponsor is Carl Allen, running 1 of these trials.
Enrollment posture brief
Registry condition langerhans-cell-histiocytosis
OPEN 5 | RECR 56% | LATE 1 | EARLY 7 | RANK #1916 | SPON 1
Volume-matched condition peers
Nearest open-share peer: Advanced Colorectal Cancer (56% recruiting · 9 trials)
Langerhans Cell Histiocytosis lists 5 open slots (56% of 9 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Langerhans Cell Histiocytosis on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Langerhans Cell Histiocytosis is recruiting above its size-band peers.
5 of 9 indexed trials (55.6%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Langerhans Cell Histiocytosis trials is spread across many organizations.
Carl Allen accounts for 1 of 9 trials (11.1%). 9 distinct sponsors appear on at least one study for this condition label.
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Typical Langerhans Cell Histiocytosis enrolment sits around 90 participants.
Median target enrolment is 90 among the 9 trials that report a genuine target (sentinel values excluded). 5 of those (55.6%) plan for fewer than 100 participants.
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Langerhans Cell Histiocytosis research is mostly interventional.
8 interventional and 1 observational studies make up this index (88.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
9 total, page 1 of 1
Histiocytic Disorder Follow-up Study
University of Alabama at Birmingham
NCT05915208
LCH-IV, International Collaborative Treatment Protocol for Children and Adolescents With Langerhans Cell Histiocytosis
North American Consortium for Histiocytosis
NCT02205762
Vinblastine/Prednisone Versus Single Therapy With Cytarabine for Langerhans Cell Histiocytosis (LCH)
Baylor College of Medicine
NCT02670707
Cobimetinib in Refractory Langerhans Cell Histiocytosis (LCH), and Other Histiocytic Disorders
Carl Allen
NCT04079179
Targeted Approach to Langerhans Cell Histiocytosis (LCH) Using MEK Inhibitor, Trametinib
Cook Children's Health Care System
NCT06582745
Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)
National Cancer Institute (NCI)
NCT03155620
Study of Clofarabine in Patients With Recurrent or Refractory Langerhans Cell Histiocytosis and LCH-related Disorders
Dana-Farber Cancer Institute
NCT02425904
A Study to Test the Ability of and Safety of GSK2110183 in Treating Langerhans Cell Histiocytosis
GlaxoSmithKline
NCT01395004
Study of Sequential Administration of Oral 6-Thioguanine After Methotrexate in Patients With LCH
Memorial Sloan Kettering Cancer Center
NCT00588536
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 7 |
| Phase 3 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Langerhans Cell Histiocytosis records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Langerhans Cell Histiocytosis trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Langerhans Cell Histiocytosis page
9 registered trials, 5 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 5 Langerhans Cell Histiocytosis trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Carl Allen sponsors the most Langerhans Cell Histiocytosis trials on record, review their full trial history before evaluating a specific study. See Carl Allen's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Langerhans Cell Histiocytosis condition card totals 9 registered trials; most-linked intervention Methotrexate; top US site state Texas. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.