Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Hyperinsulinism: early-phase trial registry
4 of 6 indexed Hyperinsulinism trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #2,866 of 28,707 conditions by registered trial count.
6 US clinical trials · 4 currently recruiting · #2,866 of 28,707 conditions by registered trial count
Hyperinsulinism: 6 US clinical trials tracked, 4 recruiting.
Hyperinsulinism is the subject of 6 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 3 in Phase 1-2 (earlier-stage). The most active sponsor is Children's Hospital of Philadelphia, running 2 of these trials.
Enrollment posture brief
Registry condition hyperinsulinism
OPEN 4 | RECR 67% | LATE 0 | EARLY 3 | RANK #2866 | SPON 2
Volume-matched condition peers
Nearest open-share peer: Adenocarcinoma of Lung (67% recruiting · 6 trials)
Hyperinsulinism lists 4 open slots (67% of 6 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Hyperinsulinism on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Hyperinsulinism is recruiting above its size-band peers.
4 of 6 indexed trials (66.7%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Hyperinsulinism research.
Children's Hospital of Philadelphia accounts for 2 of 6 trials (33.3%). 5 distinct sponsors appear on at least one study for this condition label.
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Typical Hyperinsulinism enrolment sits around 106 participants.
Median target enrolment is 106 among the 6 trials that report a genuine target (sentinel values excluded). 2 of those (33.3%) plan for fewer than 100 participants.
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Hyperinsulinism research is mostly interventional.
5 interventional and 1 observational studies make up this index (83.3% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
6 total, page 1 of 1
Fasting Insulin and HOMA-IR by Age, Sex, Race/Ethnicity, BMI, and PCOS Diagnosis
Lilli Health
NCT05950282
Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes
Colorado State University
NCT05543083
Utility of 18FDOPA PET/MRI for Focal Hyperinsulinism
Washington University School of Medicine
NCT05088798
Study to Evaluate Biomarkers and Safety of Dapagliflozin Concomitant with Neoadjuvant Therapy
Yale University
NCT05989347
Utility of [F-18] fluoroDOPA for Neonatal Hyperinsulinism
Children's Hospital of Philadelphia
NCT00674440
Bionic Pancreas in Children With Hyperinsulinism and Post-Pancreatectomy Diabetes
Children's Hospital of Philadelphia
NCT03303196
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Hyperinsulinism records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Hyperinsulinism trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Hyperinsulinism page
6 registered trials, 4 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 4 Hyperinsulinism trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Children's Hospital of Philadelphia sponsors the most Hyperinsulinism trials on record, review their full trial history before evaluating a specific study. See Children's Hospital of Philadelphia's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Hyperinsulinism condition card totals 6 registered trials; most-linked intervention PET scan; top US site state Pennsylvania. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.