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Hereditary Spastic Paraplegia clinical trials
5 of 6 indexed Hereditary Spastic Paraplegia trials are currently recruiting.
Corpus placement: #2,866 of 28,707 conditions by registered trial count.
6 US clinical trials · 5 currently recruiting · #2,866 of 28,707 conditions by registered trial count
Hereditary Spastic Paraplegia: 6 US clinical trials tracked, 5 recruiting.
Hereditary Spastic Paraplegia is the subject of 6 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. The most active sponsor is Boston Children's Hospital, running 3 of these trials.
Enrollment posture brief
Registry condition hereditary-spastic-paraplegia
OPEN 5 | RECR 83% | LATE 0 | EARLY 0 | RANK #2866 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Alcoholic Hepatitis (83% recruiting · 6 trials)
Hereditary Spastic Paraplegia lists 5 open slots (83% of 6 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Hereditary Spastic Paraplegia on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Hereditary Spastic Paraplegia is recruiting above its size-band peers.
5 of 6 indexed trials (83.3%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Hereditary Spastic Paraplegia research.
Boston Children's Hospital accounts for 3 of 6 trials (50%). 4 distinct sponsors appear on at least one study for this condition label.
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Typical Hereditary Spastic Paraplegia enrolment sits around 200 participants.
Median target enrolment is 200 among the 6 trials that report a genuine target (sentinel values excluded). 2 of those (33.3%) plan for fewer than 100 participants.
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Hereditary Spastic Paraplegia research leans observational.
1 interventional and 5 observational studies make up this index (16.7% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
6 total, page 1 of 1
Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia
Boston Children's Hospital
NCT04712812
Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)
Boston Children's Hospital
NCT05354622
Spastic Paraplegia - Centers of Excellence Research Network
Boston Children's Hospital
NCT06553976
Natural History Study of Patients with HPDL Mutations
University of California, San Diego
NCT05848271
Neuromodulation to Enhance Motor Function in HSP
Rahul Sachdeva
NCT07417943
Phenotype, Genotype and Biomarkers 2
University of Miami
NCT04875416
Phase Distribution
Phase data not available
Top Sponsors
Named interventions
Most-linked intervention names on Hereditary Spastic Paraplegia records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Hereditary Spastic Paraplegia trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Hereditary Spastic Paraplegia page
6 registered trials, 5 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 5 Hereditary Spastic Paraplegia trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Boston Children's Hospital sponsors the most Hereditary Spastic Paraplegia trials on record, review their full trial history before evaluating a specific study. See Boston Children's Hospital's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Hereditary Spastic Paraplegia condition card totals 6 registered trials; most-linked intervention transcutaneous spinal cord stimulation; top US site state Massachusetts. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.