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ClinicalTrials.gov 6 recruiting now official registry

HER2 + Breast Cancer clinical trials

6 of 9 indexed HER2 + Breast Cancer trials are currently recruiting.

9 US clinical trials · 6 currently recruiting

HER2 + Breast Cancer is the subject of 9 registered US clinical trials on ClinicalTrials.gov, 6 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most active sponsor is Nagoya City University, running 1 of these trials.

The research picture

HER2 + Breast Cancer has 9 registered US clinical trials, 6 of them open to new participants right now, about 67% of the total.

6
recruiting participants now
67%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
1
top sponsor: Nagoya City University
Phase 12Phase 24

Active & Recent Trials

9 total, page 1 of 1

RECRUITING 1,000 participants

HER2-positive Breast Cancer Registry

Priyanka Sharma

NCT06603597

RECRUITING 900 participants

Evaluating Minimal Residual Disease (MRD) Through Longitudinal Circulating Tumor DNA (ctDNA) Profiling in Breast Malignancies

Tempus AI

NCT07211178

RECRUITING Phase 2 297 participants

PhII Randomized CAPecitabine + ELAcestrant vs. Capecitabine Alone in ER+ Breast Cancer (CAPELA)

Kristina A. Fanucci

NCT07222215

RECRUITING Phase 1 243 participants

A Phase 1/1b Study of IAM1363 in HER2 Cancers

Iambic Therapeutics

NCT06253871

RECRUITING Phase 2 40 participants

A Study on Adding Precisely Targeted Radiation Therapy (Stereotactic Body Radiation Therapy) to the Usual Treatment Approach (Drug Therapy) in People With Breast Cancer

Memorial Sloan Kettering Cancer Center

NCT05534438

RECRUITING Phase 1 20 participants

A Study to Assess CLBR001+ABBV-461 in Subjects With Locally Advanced or Metastatic Breast Cancer

Calibr, a division of Scripps Research

NCT06878248

ACTIVE NOT RECRUITING 50 participants

Personalized Detection of ctDNA for Patients With HER2-Positive Metastatic Breast Cancer Who Achieved Durable Response by Anti-HER2 Treatment (HER2 CR)

Nagoya City University

NCT06663787

ACTIVE NOT RECRUITING Phase 2 8 participants

A Study to Evaluate Concurrent VRP-HER2 Vaccination and Pembrolizumab for Patients With Breast Cancer

Herbert Lyerly

NCT03632941

ACTIVE NOT RECRUITING Phase 2 7 participants

HER2HEART-US: Prevention of Cardiotoxicity in Breast Cancer Patients Receiving HER2-directed Therapy

Washington University School of Medicine

NCT06844669

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the HER2 + Breast Cancer Trial Landscape

9 indexed HER2 + Breast Cancer studies · 6 recruiting (67%).

Phase mix: 0 late (III/IV) vs 6 early (I/II).

Top sponsor: Nagoya City University (1 trial), 8 others listed. 9 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for HER2 + Breast Cancer?

PlainTrial tracks 9 US clinical trials for HER2 + Breast Cancer, of which 6 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for HER2 + Breast Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.