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Heart Failure With Preserved Ejection Fraction (HFPEF) clinical trials
8 of 10 indexed Heart Failure With Preserved Ejection Fraction (HFPEF) trials are currently recruiting.
10 US clinical trials · 8 currently recruiting
Heart Failure With Preserved Ejection Fraction (HFPEF) is the subject of 10 registered US clinical trials on ClinicalTrials.gov, 8 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is Occlutech International AB, running 1 of these trials.
The research picture
Heart Failure With Preserved Ejection Fraction (HFPEF) has 10 registered US clinical trials, 8 of them open to new participants right now, about 80% of the total.
- 8
- recruiting participants now
- 80%
- of trials open to enrollment
- 2
- in Phase 3–4 (later-stage)
- 1
- top sponsor: Occlutech International AB
Active & Recent Trials
10 total, page 1 of 1
ELEVATE-HFpEF Clinical Study
Medtronic Cardiac Rhythm and Heart Failure
NCT06678841
IRONICA: IRON Repletion In Heart Failure - A Comparison of Oral and IV Approaches
Syed Hamza Mufarrih
NCT07053475
Women's Ischemia Syndrome Evaluation (WISE) Pre-HFpEF
Cedars-Sinai Medical Center
NCT03876223
Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects Having HFpEF
Axon Therapies
NCT04592445
The Effect of Adiposity on Muscle and Microvascular Function in HFpEF
University of Texas Southwestern Medical Center
NCT06930495
The Epidemiology and Pathophysiology of Kidney Disease in HFpEF With Obesity
University of Mississippi Medical Center
NCT07052539
A Safety, Tolerability, and Biomarker Trial of VS-041 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
Vasa Therapeutics
NCT07219511
Study in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
Secretome Therapeutics
NCT06560762
Flow Regulation by Opening the SepTum in Patients With Heart Failure; a Prospective, Randomized, Sham-controlled, Double-blind, Global Multicenter Study
Occlutech International AB
NCT05136820
Changes in NT-proBNP, Safety, and Tolerability in HFpEF Patients With a WHF Event (HFpEF Decompensation) Who Have Been Stabilized and Initiated at the Time of or Within 30 Days Post-decompensation (PARAGLIDE-HF)
Novartis Pharmaceuticals
NCT03988634
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 3 | 1 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Heart Failure With Preserved Ejection Fraction (HFPEF) Trial Landscape
10 indexed Heart Failure With Preserved Ejection Fraction (HFPEF) studies · 8 recruiting (80%).
Phase mix: 2 late (III/IV) vs 2 early (I/II).
Top sponsor: Occlutech International AB (1 trial), 9 others listed. 10 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Heart Failure With Preserved Ejection Fraction (HFPEF)?
PlainTrial tracks 10 US clinical trials for Heart Failure With Preserved Ejection Fraction (HFPEF), of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Heart Failure With Preserved Ejection Fraction (HFPEF)?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.