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ClinicalTrials.gov 8 recruiting now official registry

Heart Failure With Preserved Ejection Fraction (HFPEF) clinical trials

8 of 10 indexed Heart Failure With Preserved Ejection Fraction (HFPEF) trials are currently recruiting.

10 US clinical trials · 8 currently recruiting

Heart Failure With Preserved Ejection Fraction (HFPEF) is the subject of 10 registered US clinical trials on ClinicalTrials.gov, 8 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is Occlutech International AB, running 1 of these trials.

The research picture

Heart Failure With Preserved Ejection Fraction (HFPEF) has 10 registered US clinical trials, 8 of them open to new participants right now, about 80% of the total.

8
recruiting participants now
80%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
1
top sponsor: Occlutech International AB
Phase 12Phase 31Phase 41

Active & Recent Trials

10 total, page 1 of 1

RECRUITING NA 700 participants

ELEVATE-HFpEF Clinical Study

Medtronic Cardiac Rhythm and Heart Failure

NCT06678841

RECRUITING Phase 4 250 participants

IRONICA: IRON Repletion In Heart Failure - A Comparison of Oral and IV Approaches

Syed Hamza Mufarrih

NCT07053475

RECRUITING 180 participants

Women's Ischemia Syndrome Evaluation (WISE) Pre-HFpEF

Cedars-Sinai Medical Center

NCT03876223

RECRUITING NA 150 participants

Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects Having HFpEF

Axon Therapies

NCT04592445

RECRUITING 100 participants

The Effect of Adiposity on Muscle and Microvascular Function in HFpEF

University of Texas Southwestern Medical Center

NCT06930495

RECRUITING 60 participants

The Epidemiology and Pathophysiology of Kidney Disease in HFpEF With Obesity

University of Mississippi Medical Center

NCT07052539

RECRUITING Phase 1 42 participants

A Safety, Tolerability, and Biomarker Trial of VS-041 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)

Vasa Therapeutics

NCT07219511

RECRUITING Phase 1 12 participants

Study in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)

Secretome Therapeutics

NCT06560762

ACTIVE NOT RECRUITING NA 15 participants

Flow Regulation by Opening the SepTum in Patients With Heart Failure; a Prospective, Randomized, Sham-controlled, Double-blind, Global Multicenter Study

Occlutech International AB

NCT05136820

COMPLETED Phase 3 467 participants

Changes in NT-proBNP, Safety, and Tolerability in HFpEF Patients With a WHF Event (HFpEF Decompensation) Who Have Been Stabilized and Initiated at the Time of or Within 30 Days Post-decompensation (PARAGLIDE-HF)

Novartis Pharmaceuticals

NCT03988634

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 3 1
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Heart Failure With Preserved Ejection Fraction (HFPEF) Trial Landscape

10 indexed Heart Failure With Preserved Ejection Fraction (HFPEF) studies · 8 recruiting (80%).

Phase mix: 2 late (III/IV) vs 2 early (I/II).

Top sponsor: Occlutech International AB (1 trial), 9 others listed. 10 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Heart Failure With Preserved Ejection Fraction (HFPEF)?

PlainTrial tracks 10 US clinical trials for Heart Failure With Preserved Ejection Fraction (HFPEF), of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Heart Failure With Preserved Ejection Fraction (HFPEF)?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.