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NCT06930495 · ClinicalTrials.gov registry record
The Effect of Adiposity on Muscle and Microvascular Function in HFpEF
A clinical trial of Heart Failure With Preserved Ejection Fraction (HFPEF), sponsored by University of Texas Southwestern Medical Center.
- Recruiting
- Registry status
- 100
- Enrollment target
- 1
- Study location
NCT06930495: Recruiting study of Heart Failure With Preserved Ejection Fraction (HFPEF), sponsored by University of Texas Southwestern Medical Center.
NCT06930495 is a study of Heart Failure With Preserved Ejection Fraction (HFPEF) that is actively recruiting participants, run by University of Texas Southwestern Medical Center. The registered enrollment target is 100 participants, below the 208-participant average among 9 other Heart Failure With Preserved Ejection Fraction (HFPEF) trials with a reported enrollment target (52% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06930495, a study of Heart Failure With Preserved Ejection Fraction (HFPEF), is actively recruiting participants, sponsored by University of Texas Southwestern Medical Center.
- RECRUITING
- Registry status
- 100 participants
- Enrollment target
- 1
- Study location
Study Summary
This project is an observational study in patients with heart failure with preserved ejection fraction (HFpEF) who are candidates for treatment with weight loss medication to manage obesity or diabetes as part of their standard clinical care. This study will include multiple experimental visits before and after treatment (minimum 7 percent weight loss, between 9-12 months) to understand how increased adiposity and inflammation effects skeletal muscle and cardiovascular health and function and to examine the effect of medically directed weight loss on skeletal muscle health and exercise tolerance. The objective of this study is to 1. Define the mechanisms by which adiposity impairs exercise hemodynamics, microvascular function, and oxygen transport/utilization in patients with HFpEF. 2. Determine if intensive medically directed weight loss can reduce microvascular inflammation and normalize exercise hemodynamics. 3. Quantify the effect of medically directed weight loss on skeletal muscle function and catabolism. Hypotheses 1. Perfusion of subcutaneous adipose tissue disrupts blood flow distribution and impairs muscle microvascular perfusion and exercise hemodynamics. 2. Extramyocellular muscular lipid deposition and microvascular endothelial inflammation is associated with reduced capillarity and impaired microvascular perfusions, while intramyocellular triglyceride content is associated with poor skeletal muscle oxidative capacity, 3. Intensive weight loss will improve exercise hemodynamics, microvascular perfusion, and reduce muscular inflammation, and resistance training will augment these effects.
Conditions Studied
Interventions
- DRUG Weight loss SOC Treatment with second generation anti-diabetic medications
Study Locations (1)
Texas
- University of Texas Southwestern Medical Center - Dallas
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2024-12-10 |
| Est. Completion | 2026-06-01 |
What NCT06930495 shows while recruiting
NCT06930495 is an observational study that tracks outcomes without assigning an intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 208-participant average among 9 other Heart Failure With Preserved Ejection Fraction (HFPEF) trials with a reported enrollment target (52% lower).
The record links to 1 condition, with Heart Failure With Preserved Ejection Fraction (HFPEF) appearing as the primary indexed condition, and to 1 intervention - of which Weight loss SOC Treatment with second generation anti-diabetic medications is the first listed.
NCT06930495 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT06930495 about?
NCT06930495 is a clinical study titled "The Effect of Adiposity on Muscle and Microvascular Function in HFpEF". This project is an observational study in patients with heart failure with preserved ejection fraction (HFpEF) who are candidates for treatment with weight loss medication to manage obesity or diabetes as part of their standard clinical care. This study will include multiple experimental visits befo...
What is the current status of trial NCT06930495?
This trial is currently recruiting. The enrollment target is 100 participants. The study started on 2024-12-10. Estimated completion is 2026-06-01.
What conditions does trial NCT06930495 study?
This clinical trial studies the following conditions: Heart Failure With Preserved Ejection Fraction (HFPEF).
What interventions are being tested in trial NCT06930495?
The interventions under investigation include: Weight loss SOC Treatment with second generation anti-diabetic medications (DRUG).
Who is sponsoring clinical trial NCT06930495?
This trial is sponsored by University of Texas Southwestern Medical Center, which has 837 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06930495 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Heart Failure With Preserved Ejection Fraction (HFPEF)
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06930495's enrollment target sits among peer trials
100 6th of 9 higher than 4 of 9 other Heart Failure With Preserved Ejection Fraction (HFPEF) trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Heart Failure With Preserved Ejection Fraction (HFPEF) trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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