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NCT03876223 · ClinicalTrials.gov registry record
Women's Ischemia Syndrome Evaluation (WISE) Pre-HFpEF
A clinical trial of Heart Failure With Preserved Ejection Fraction (HFPEF) and Coronary Microvascular Dysfunction, sponsored by Cedars-Sinai Medical Center.
- Recruiting
- Registry status
- 180
- Enrollment target
- 2
- Study locations
NCT03876223: Recruiting study of Heart Failure With Preserved Ejection Fraction (HFPEF) and Coronary Microvascular Dysfunction, sponsored by Cedars-Sinai Medical Center.
NCT03876223 is a study of Heart Failure With Preserved Ejection Fraction (HFPEF) and Coronary Microvascular Dysfunction that is actively recruiting participants, run by Cedars-Sinai Medical Center. The registered enrollment target is 180 participants, below the 200-participant average among 9 other Heart Failure With Preserved Ejection Fraction (HFPEF) trials with a reported enrollment target (10% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03876223, a study of Heart Failure With Preserved Ejection Fraction (HFPEF) and Coronary Microvascular Dysfunction, is actively recruiting participants, sponsored by Cedars-Sinai Medical Center.
- RECRUITING
- Registry status
- 180 participants
- Enrollment target
- 2
- Study locations
Study Summary
The purpose of this study is to examine small vessel disease (a condition in which the small arteries in the heart become narrowed). The investigators want to know how the small vessel disease contributes to pre-HFpEF (a condition with inadequate heart muscle function in the setting of preserved muscle pumping) and to better identify potential treatment for prevention of HFpEF. The main procedures of this study include up to 2 clinic visits (initial visit and a second clinical visit only if participants are unable to complete all research procedures at the initial visit); a 6-week phone interview visit, 4 quarterly follow-up phone interview visits in year 1; year 1 follow up cardiac MRI based on availability and ongoing annual follow-up phone interview visits to track progress. If participants choose to take part in this study, participants direct participation will end after 1 year, participants will then have the option of participating in ongoing annual check-in calls. Participants will be asked to undergo a physical exam and provide a completed medical history; complete a Cardiovascular (or Cardiac) Magnetic Resonance Imaging (CMRI) with contrast agent; complete questionnaires to describe heart symptoms and overall quality of life status; undergo blood draws to provide blood samples for research testing, and allow the study team to have access to medical records.
Primary Outcome
Change from Baseline at 1 year follow up will be assessed.
Conditions Studied
Study Locations (2)
California
- Cedars-Sinai Medical Center - Los Angeles
Florida
- University of Florida - Gainesville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 180 participants |
| Start Date | 2019-07-24 |
| Est. Completion | 2026-02-28 |
What NCT03876223 shows while recruiting
NCT03876223 is an observational study that tracks outcomes without assigning an intervention. The registered 180 participants enrollment target is mid-sized for trials with a published cap, below the 200-participant average among 9 other Heart Failure With Preserved Ejection Fraction (HFPEF) trials with a reported enrollment target (10% lower).
The record links to 2 conditions, with Heart Failure With Preserved Ejection Fraction (HFPEF) appearing as the primary indexed condition, and to 0 interventions.
NCT03876223 reports a single indexed study location in California, Florida.
Frequently Asked Questions
What is clinical trial NCT03876223 about?
NCT03876223 is a clinical study titled "Women's Ischemia Syndrome Evaluation (WISE) Pre-HFpEF". The purpose of this study is to examine small vessel disease (a condition in which the small arteries in the heart become narrowed). The investigators want to know how the small vessel disease contributes to pre-HFpEF (a condition with inadequate heart muscle function in the setting of preserved mus...
What is the current status of trial NCT03876223?
This trial is currently recruiting. The enrollment target is 180 participants. The study started on 2019-07-24. Estimated completion is 2026-02-28.
What conditions does trial NCT03876223 study?
This clinical trial studies the following conditions: Heart Failure With Preserved Ejection Fraction (HFPEF), Coronary Microvascular Dysfunction.
Who is sponsoring clinical trial NCT03876223?
This trial is sponsored by Cedars-Sinai Medical Center, which has 339 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03876223 being conducted?
This trial has 2 study locations across California, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Heart Failure With Preserved Ejection Fraction (HFPEF)
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03876223's enrollment target sits among peer trials
180 4th of 9 higher than 6 of 9 other Heart Failure With Preserved Ejection Fraction (HFPEF) trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Heart Failure With Preserved Ejection Fraction (HFPEF) trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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