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ClinicalTrials.gov 8 recruiting now official registry

Hairy Cell Leukemia clinical trials

8 of 16 indexed Hairy Cell Leukemia trials are currently recruiting.

16 US clinical trials · 8 currently recruiting

Hairy Cell Leukemia is the subject of 16 registered US clinical trials on ClinicalTrials.gov, 8 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 16 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 9 of these trials.

The research picture

Hairy Cell Leukemia has 16 registered US clinical trials, 8 of them open to new participants right now, about 50% of the total.

8
recruiting participants now
50%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
9
top sponsor: National Cancer Institute (NCI)
Phase 15Phase 211

Active & Recent Trials

16 total, page 1 of 1

RECRUITING Phase 2 150 participants

Cladribine and Rituximab in Treating Patients With Hairy Cell Leukemia

M.D. Anderson Cancer Center

NCT00412594

RECRUITING Phase 1 148 participants

AutologousCD22 Chimeric Antigen Receptor (CAR)T Cells in w/Recurrent/Refractory B Cell Lymphomas

Stanford University

NCT06340737

RECRUITING Phase 2 86 participants

A Study of Vemurafenib and Obinutuzumab Compared to Cladribine and Rituximab in People With Hairy Cell Leukemia (HCL)

Memorial Sloan Kettering Cancer Center

NCT06561360

RECRUITING Phase 1 84 participants

Testing the Combination of Anti-cancer Drugs, Tovorafenib Plus Rituximab, in Patients With Hairy Cell Leukemia

National Cancer Institute (NCI)

NCT06965114

RECRUITING Phase 1 60 participants

Study of Oral Administration of LP-168 in Patients With Relapsed or Refractory B-cell Malignancies.

Newave Pharmaceutical

NCT04775745

RECRUITING Phase 2 45 participants

Encorafenib Plus Binimetinib for People With BRAF V600 Mutated Relapsed/Refractory HCL

National Cancer Institute (NCI)

NCT04324112

RECRUITING Phase 2 40 participants

Binimetinib for People With Relapsed/Refractory BRAF Wild Type Hairy Cell Leukemia and Variant

National Cancer Institute (NCI)

NCT04322383

RECRUITING Phase 1 27 participants

Phase I Study of Anti-CD22 Chimeric Receptor T Cells in Patients With Relapsed/Refractory Hairy Cell Leukemia and Variant

National Cancer Institute (NCI)

NCT04815356

ACTIVE NOT RECRUITING Phase 2 175 participants

Cladribine With Simultaneous or Delayed Rituximab to Treat Hairy Cell Leukemia

National Cancer Institute (NCI)

NCT00923013

ACTIVE NOT RECRUITING Phase 2 69 participants

Randomized Phase II Trial of Rituximab With Either Pentostatin or Bendamustine for Multiply Relapsed or Refractory Hairy Cell Leukemia

National Cancer Institute (NCI)

NCT01059786

ACTIVE NOT RECRUITING Phase 2 44 participants

Ibrutinib in Treating Patients With Relapsed Hairy Cell Leukemia

National Cancer Institute (NCI)

NCT01841723

ACTIVE NOT RECRUITING Phase 2 30 participants

A Phase II Study of the BRAF Inhibitor, Vemurafenib, Plus Obinutuzumab in Patients With Previously Untreated Classical Hairy Cell Leukemia

Memorial Sloan Kettering Cancer Center

NCT03410875

ACTIVE NOT RECRUITING Phase 2 20 participants

Low Dose Vemurafenib and Rituximab in Hairy Cell Leukemia

Scripps Health

NCT05388123

ACTIVE NOT RECRUITING Phase 1 18 participants

Moxetumomab Pasudotox-tdfk (Lumoxiti(TM)) and Either Rituximab (Rituxan(R)) or Ruxience for Relapsed Hairy Cell Leukemia

National Cancer Institute (NCI)

NCT03805932

COMPLETED Phase 2 56 participants

A Phase II Efficacy Study of Roferon-A in Hairy Cell Leukemia

National Cancer Institute (NCI)

NCT00001567

COMPLETED Phase 2 36 participants

BRAF Inhibitor, Vemurafenib, in Patients With Relapsed or Refractory Hairy Cell Leukemia

Memorial Sloan Kettering Cancer Center

NCT01711632

Phase Distribution

PhaseTrial count
Phase 1 5
Phase 2 11

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Hairy Cell Leukemia Trial Landscape

16 indexed Hairy Cell Leukemia studies · 8 recruiting (50%).

Phase mix: 0 late (III/IV) vs 16 early (I/II).

Top sponsor: National Cancer Institute (NCI) (9 trials), 5 others listed. 16 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Hairy Cell Leukemia?

PlainTrial tracks 16 US clinical trials for Hairy Cell Leukemia, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Hairy Cell Leukemia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.