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ClinicalTrials.gov 4 recruiting now official registry

Gastrointestinal Stromal Tumors clinical trials

4 of 12 indexed Gastrointestinal Stromal Tumors trials are currently recruiting.

12 US clinical trials · 4 currently recruiting

Gastrointestinal Stromal Tumors is the subject of 12 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 9 in Phase 1-2 (earlier-stage). The most active sponsor is Novartis Pharmaceuticals, running 2 of these trials.

The research picture

Gastrointestinal Stromal Tumors has 12 registered US clinical trials, 4 of them open to new participants right now, about 33% of the total.

4
recruiting participants now
33%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
2
top sponsor: Novartis Pharmaceuticals
Phase 13Phase 26Phase 32

Active & Recent Trials

12 total, page 1 of 1

RECRUITING open-ended (no fixed target)

Integrated Cancer Repository for Cancer Research

University of Nebraska

NCT02012699

RECRUITING Phase 1 67 participants

A Study of the c-Kit Specific Antibody-Drug Conjugate NN3201 for Advanced and/or Metastatic Solid Tumors Known to Express c-Kit

Novelty Nobility

NCT06805825

RECRUITING Phase 2 48 participants

ctDNA-Guided Sunitinib And Regorafenib Therapy for GIST

University of Miami

NCT05366816

RECRUITING Phase 2 28 participants

Imatinib TDM in GIST

Reema A. Patel

NCT05493215

ACTIVE NOT RECRUITING Phase 3 453 participants

A Study of Ripretinib vs Sunitinib in Advanced GIST Patients After Treatment With Imatinib

Deciphera Pharmaceuticals

NCT03673501

ACTIVE NOT RECRUITING Phase 2 40 participants

SARC044: A Phase II Trial of Bezuclastinib in Combination With Sunitinib in Patients With GIST

Sarcoma Alliance for Research through Collaboration

NCT06208748

ACTIVE NOT RECRUITING Phase 2 23 participants

Temozolomide (TMZ) in Advanced Succinate Dehydrogenase (SDH)-Mutant/Deficient Gastrointestinal Stromal Tumor (GIST)

Adam Burgoyne, MD, PhD

NCT03556384

ACTIVE NOT RECRUITING Phase 2 3 participants

Phase 2 Study to Evaluate the Efficacy of Regorafenib in Specific GIST Mutation Subsets (KIT Exon 17, 18, or 14 Mutation and SDHB Deficient GIST) in the Post-imatinib Second-line Setting.

M.D. Anderson Cancer Center

NCT06087263

COMPLETED Phase 3 199 participants

Study of Regorafenib as a 3rd-line or Beyond Treatment for Gastrointestinal Stromal Tumors (GIST)

Bayer

NCT01271712

COMPLETED Phase 1 59 participants

Study of AMN107 With Imatinib in Gastrointestinal Stromal Tumors (GIST)

Novartis Pharmaceuticals

NCT00135005

COMPLETED Phase 2 16 participants

A Phase 2 Study of XL820 in Adults With Advanced GIST Resistant to Imatinib and/or Sunitinib

Exelixis

NCT00570635

COMPLETED Phase 1 14 participants

Patients Completing Core Protocol (CAMN107A2103), Exhibiting Stable Disease (SD), Partial Response (PR) or Complete Response (CR) to Nilotinib in Combination With Imatinib

Novartis Pharmaceuticals

NCT00441155

Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 6
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Gastrointestinal Stromal Tumors Trial Landscape

12 indexed Gastrointestinal Stromal Tumors studies · 4 recruiting (33%).

Phase mix: 2 late (III/IV) vs 9 early (I/II).

Top sponsor: Novartis Pharmaceuticals (2 trials), 9 others listed. 12 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Gastrointestinal Stromal Tumors?

PlainTrial tracks 12 US clinical trials for Gastrointestinal Stromal Tumors, of which 4 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Gastrointestinal Stromal Tumors?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.