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ClinicalTrials.gov 6 recruiting now official registry

Esophagus Cancer clinical trials

6 of 12 indexed Esophagus Cancer trials are currently recruiting.

12 US clinical trials · 6 currently recruiting

Esophagus Cancer is the subject of 12 registered US clinical trials on ClinicalTrials.gov, 6 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most active sponsor is Washington University School of Medicine, running 3 of these trials.

The research picture

Esophagus Cancer has 12 registered US clinical trials, 6 of them open to new participants right now, about 50% of the total.

6
recruiting participants now
50%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
3
top sponsor: Washington University School of Medicine
Phase 14Phase 22

Active & Recent Trials

12 total, page 1 of 1

RECRUITING 4,000 participants

Retrospective Review of Esophageal Cancer at MSKCC

Memorial Sloan Kettering Cancer Center

NCT05706558

RECRUITING 1,000 participants

Mayo Clinic Upper Digestive Disease Survey

Mayo Clinic

NCT02530983

RECRUITING Phase 1 42 participants

CA-4948 in Combination With FOLFOX/PD-1 Inhibitor +/- Trastuzumab for Untreated Unresectable Gastric and Esophageal Cancer

Washington University School of Medicine

NCT05187182

RECRUITING Phase 2 40 participants

Ivonescimab in Comb. With FOLFOX in Advanced HER2 Neg. GEA

Massachusetts General Hospital

NCT07070466

RECRUITING NA 38 participants

Proton Therapy for Esophageal Cancer

Loma Linda University

NCT01684904

RECRUITING NA 36 participants

Individualized Dose Escalation of 5-FU for Gastrointestinal Cancer

Dartmouth-Hitchcock Medical Center

NCT05780684

ACTIVE NOT RECRUITING Phase 1 130 participants

Study of CBX-12 in Subjects With Advanced or Metastatic Refractory Solid Tumors

Cybrexa Therapeutics

NCT04902872

ACTIVE NOT RECRUITING 28 participants

Imaging and Blood-Based Biomarkers for the Evaluation of Early Signs of Myocardial Injury After Thoracic Radiation Therapy

Ohio State University Comprehensive Cancer Center

NCT05717998

ACTIVE NOT RECRUITING NA 22 participants

Proton Beam Therapy in the Treatment of Esophageal Cancer

Washington University School of Medicine

NCT03482791

ACTIVE NOT RECRUITING Phase 1 12 participants

Radiation Dose Intensification With Accelerated Hypofractionated Intensity Modulated Radiation Therapy and Concurrent Carboplatin and Paclitaxel for Inoperable Esophageal Cancer

Washington University School of Medicine

NCT04046575

COMPLETED Phase 1 23 participants

Clinical Trial of Metastasis Inhibitor NP-G2-044 in Patients With Advanced or Metastatic Treatment-Refractory Solid Tumor Malignancies

Novita Pharmaceuticals

NCT03199586

COMPLETED Phase 2 5 participants

Tisotumab Vedotin Continued Treatment in Patients With Solid Tumors.

Seagen

NCT03245736

Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Esophagus Cancer Trial Landscape

12 indexed Esophagus Cancer studies · 6 recruiting (50%).

Phase mix: 0 late (III/IV) vs 6 early (I/II).

Top sponsor: Washington University School of Medicine (3 trials), 9 others listed. 12 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Esophagus Cancer?

PlainTrial tracks 12 US clinical trials for Esophagus Cancer, of which 6 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Esophagus Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.