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ClinicalTrials.gov 15 recruiting now official registry

Esophageal Squamous Cell Carcinoma clinical trials

15 of 23 indexed Esophageal Squamous Cell Carcinoma trials are currently recruiting.

23 US clinical trials · 15 currently recruiting

Esophageal Squamous Cell Carcinoma is the subject of 23 registered US clinical trials on ClinicalTrials.gov, 15 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 16 in Phase 1-2 (earlier-stage). The most active sponsor is Seagen, a wholly owned subsidiary of Pfizer, running 2 of these trials.

The research picture

Esophageal Squamous Cell Carcinoma has 23 registered US clinical trials, 15 of them open to new participants right now, about 65% of the total.

15
recruiting participants now
65%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
2
top sponsor: Seagen, a wholly owned subsidiary of Pfizer
Phase 114Phase 22Phase 34

Active & Recent Trials

23 total, page 1 of 1

RECRUITING 1,650 participants

A Multicenter Cancer Biospecimen Collection Study

Cofactor Genomics

NCT04510129

RECRUITING Phase 1 1,006 participants

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

Seagen, a wholly owned subsidiary of Pfizer

NCT04389632

RECRUITING Phase 1 714 participants

A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors

Seagen, a wholly owned subsidiary of Pfizer

NCT05208762

RECRUITING Phase 3 510 participants

A Study of Ifinatamab Deruxtecan in Subjects With Pretreated Advanced or Metastatic Esophageal Squamous Cell Carcinoma (ESCC) (IDeate-Esophageal01)

Daiichi Sankyo

NCT06644781

RECRUITING Phase 1 310 participants

A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors

Pfizer

NCT07090499

RECRUITING Phase 1 298 participants

Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06)

Merck Sharp & Dohme

NCT06780111

RECRUITING Phase 1 230 participants

A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B)

Merck Sharp & Dohme

NCT05319730

RECRUITING Phase 1 205 participants

A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations

Terremoto Biosciences

NCT07109726

RECRUITING Phase 1 170 participants

A Study to Investigate ALE.P02 as Monotherapy in Adult Patients With Selected CLDN1+ Solid Tumors

Alentis Therapeutics

NCT06747585

RECRUITING Phase 1 160 participants

A Study Evaluating the Safety, Efficacy, and Pharmacokinetics (PK) of EVOLVE104 in Participants With Advanced Urothelial and Squamous Cell Carcinomas

EvolveImmune United

NCT07217171

RECRUITING Phase 1 155 participants

First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors

Plexium

NCT07284186

RECRUITING Phase 1 134 participants

Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis

Neonc Technologies

NCT06047379

RECRUITING Phase 2 78 participants

A Phase II Trial to Evaluate the Effect of Itraconazole on Pathologic Complete Response Rates in Resectable Esophageal Cancer

VA Office of Research and Development

NCT05563766

RECRUITING Phase 1 37 participants

RAPA-201 Therapy of Solid Tumors

Rapa Therapeutics

NCT05144698

RECRUITING Phase 1 9 participants

Safety of RAD301 in Healthy Human Volunteers and Patients With Pancreatic Cancer or Other Solid Tumors

Radiopharm Theranostics

NCT05799274

ACTIVE NOT RECRUITING Phase 3 760 participants

A Study of Atezolizumab With or Without Tiragolumab in Participants With Unresectable Esophageal Squamous Cell Carcinoma Whose Cancers Have Not Progressed Following Definitive Concurrent Chemoradiotherapy

Hoffmann-La Roche

NCT04543617

ACTIVE NOT RECRUITING Phase 3 640 participants

Study of Durvalumab Versus Placebo in Combination With Definitive Chemoradiation Therapy in Patient With ESCC

AstraZeneca

NCT04550260

ACTIVE NOT RECRUITING Phase 1 302 participants

Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Select Advanced Solid Tumor Indications Receiving Intravenous (IV) ABBV-400

AbbVie

NCT06084481

ACTIVE NOT RECRUITING Phase 1 194 participants

Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combination

Merus B.V.

NCT04868877

ACTIVE NOT RECRUITING Phase 2 3 participants

Chemoradiation and Pembrolizumab Followed by Pembrolizumab and Lenvatinib Before Surgery for the Treatment of Non-metastatic Esophageal or Esophageal/Gastroesophageal Junction Cancer

City of Hope Medical Center

NCT04929392

COMPLETED Phase 3 746 participants

Sintilimab or Placebo With Chemotherapy in Esophageal Squamous Cell Carcinoma ( ORIENT-15 )

Innovent Biologics (Suzhou) Co.

NCT03748134

COMPLETED NA 50 participants

Esophageal Cytology With FISH in Detecting Esophageal Cancer

OHSU Knight Cancer Institute

NCT02100189

COMPLETED NA 11 participants

Swallowable Sponge Cell Sampling Device and Next Generation Sequencing in Detecting Esophageal Cancer in Patients With Low or High Grade Dysplasia, Barrett Esophagus, or Gastroesophageal Reflux Disease

OHSU Knight Cancer Institute

NCT02890979

Phase Distribution

PhaseTrial count
Phase 1 14
Phase 2 2
Phase 3 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Esophageal Squamous Cell Carcinoma Trial Landscape

23 indexed Esophageal Squamous Cell Carcinoma studies · 15 recruiting (65%).

Phase mix: 4 late (III/IV) vs 16 early (I/II).

Top sponsor: Seagen, a wholly owned subsidiary of Pfizer (2 trials), 9 others listed. 23 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Esophageal Squamous Cell Carcinoma?

PlainTrial tracks 23 US clinical trials for Esophageal Squamous Cell Carcinoma, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Esophageal Squamous Cell Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.