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ClinicalTrials.gov 7 recruiting now official registry

Diarrhea clinical trials

Every US clinical trial registered for Diarrhea — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

25 US clinical trials · 7 currently recruiting

The research picture

Diarrhea has 25 registered US clinical trials, 7 of them open to new participants right now — about 28% of the total.

7
recruiting participants now
28%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
2
top sponsor: Bausch Health Americas

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING Phase 1 60 participants

First in Human Dose Escalation Study Evaluating the Safety and Immunogenicity of IVT's Shigella-04 Vaccine in Healthy Young Adults

Inventprise

NCT07205926

RECRUITING Phase 4 54 participants

Rifaximin 200 mg Plus Oral Rehydration vs Oral Rehydration Alone in Children With Acute Diarrhea

Bausch Health Americas

NCT07285785

RECRUITING Phase 2 43 participants

Fecal Microbiota Transplantation for IBS

Madhusudan (Madhu) Grover, MBBS

NCT05776914

RECRUITING Phase 1 40 participants

Fecal Microbiota Transplantation in Treating Immune-Checkpoint Inhibitor Induced-Diarrhea or Colitis in Genitourinary Cancer Patients

M.D. Anderson Cancer Center

NCT04038619

RECRUITING NA 30 participants

GI Alpha-Gal Study

University of North Carolina, Chapel Hill

NCT06268717

RECRUITING Early Phase 1 20 participants

Novel Pilot Study to Treat Symptoms of IBS With Diarrhea Using Combination Therapy of a Low-FODMAP Diet and a Neuromodulator

Mayo Clinic

NCT06684470

RECRUITING Phase 1 15 participants

A Study of SER-155 to Treat Diarrhea in People on Immunotherapy

Memorial Sloan Kettering Cancer Center

NCT06801067

ACTIVE NOT RECRUITING NA 908 participants

Wells and Enteric Disease Transmission

Temple University

NCT04826991

ACTIVE NOT RECRUITING Phase 2 60 participants

Microbiota Transplant Therapy for Children With Both Autism Spectrum Disorder and Gastrointestinal Disorders

Gut-Brain-Axis Therapeutics

NCT06503978

ACTIVE NOT RECRUITING Phase 2 50 participants

MTT for Children With ASD Who Have Gastrointestinal Disorders

Arizona State University

NCT04182633

COMPLETED NA 810 participants

A Trial of Tap Water Treatment in the Elderly

National Institute on Aging (NIA)

NCT00058942

COMPLETED 308 participants

Genetic Trial to Study Diarrhea in Patients With Stage III Colon Cancer Who Are Receiving Chemotherapy

Alliance for Clinical Trials in Oncology

NCT00048971

COMPLETED NA 255 participants

Development and Validation of the Automated Evaluation of Gastrointestinal Symptoms (AEGIS) Platform

Cedars-Sinai Medical Center

NCT02436057

COMPLETED Phase 2 245 participants

A Study of Crofelemer to Treat Diarrhea Irritable Bowel Syndrome

Bausch Health Americas

NCT00101725

COMPLETED Phase 2 210 participants

Study of CB-183,315 in Participants With Clostridium Difficile Infection

Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

NCT01085591

COMPLETED Phase 2 201 participants

ETEC Logistics Trial (TREK)

Intercell USA

NCT00516659

COMPLETED Phase 3 190 participants

Yogurt Study in Children 2-4 Years Old Attending Daycare

Georgetown University

NCT00760851

COMPLETED Phase 2 60 participants

Clinical Study to Assess the Efficacy of IMM-124E (Travelan®) in a Controlled Human Infection Model

Immuron

NCT05933525

COMPLETED Phase 1 58 participants

Dose Escalating Study of Intramuscular Invaplex[AR-DETOX]

PATH

NCT03869333

COMPLETED Phase 4 41 participants

Examining the Effect of Ondansetron on Bowel Prep Success

State University of New York - Downstate Medical Center

NCT05439772

COMPLETED Phase 1 32 participants

Invaplex 50 Vaccine Dose-Ranging

U.S. Army Medical Research and Development Command

NCT00082069

COMPLETED 30 participants

AcuGraph and Digestive Symptoms

Logan College of Chiropractic

NCT00846794

COMPLETED Phase 2 25 participants

A Study of Colesevelam for Lenalidomide-Associated Diarrhea

Memorial Sloan Kettering Cancer Center

NCT03767257

COMPLETED NA 21 participants

Probiotic Yogurt Supplement in Reducing Diarrhea in Patients With Metastatic Kidney Cancer Being Treated With Vascular Endothelial Growth Factor-Tyrosine Kinase Inhibitor

City of Hope Medical Center

NCT02944617

COMPLETED Phase 1 2 participants

Irinotecan and Celecoxib in Treating Patients With Unresectable or Metastatic Colorectal Cancer

Roswell Park Cancer Institute

NCT00084721

Phase Distribution

PhaseTrial count
Phase 1 7
Phase 2 8
Phase 3 1
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Diarrhea Trial Landscape

ClinicalTrials.gov lists 25 US studies indexed under Diarrhea, and 7 of those are currently open to recruitment — roughly 28% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Diarrhea shows 3 late-stage studies (Phase 3 and Phase 4 combined) alongside 15 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Diarrhea is led by Bausch Health Americas with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 25 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Diarrhea?

PlainTrial tracks 25 US clinical trials for Diarrhea, of which 7 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Diarrhea?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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