Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Chronic Hepatitis B: full-pipeline trial registry
4 of 16 indexed Chronic Hepatitis B trials are currently recruiting.
Corpus placement: #1,060 of 28,707 conditions by registered trial count.
16 US clinical trials · 4 currently recruiting · #1,060 of 28,707 conditions by registered trial count
Chronic Hepatitis B: 16 US clinical trials tracked, 4 recruiting.
Chronic Hepatitis B is the subject of 16 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 9 in Phase 1-2 (earlier-stage). The most active sponsor is Gilead Sciences, running 8 of these trials.
Enrollment posture brief
Registry condition chronic-hepatitis-b
OPEN 4 | RECR 25% | LATE 6 | EARLY 9 | RANK #1060 | SPON 8
Volume-matched condition peers
Nearest open-share peer: Abdominal Cancer (25% recruiting · 8 trials)
Chronic Hepatitis B lists 4 open slots (25% of 16 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Chronic Hepatitis B on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Chronic Hepatitis B is recruiting below its size-band peers.
4 of 16 indexed trials (25%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Chronic Hepatitis B research.
Gilead Sciences accounts for 8 of 16 trials (50%). 6 distinct sponsors appear on at least one study for this condition label.
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Typical Chronic Hepatitis B enrolment sits around 150 participants.
Median target enrolment is 150 among the 15 trials that report a genuine target (sentinel values excluded). 6 of those (40%) plan for fewer than 100 participants.
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Chronic Hepatitis B research is mostly interventional.
15 interventional and 1 observational studies make up this index (93.8% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
16 total, page 1 of 1
Study of Tenofovir Alafenamide (TAF) in Children and Teen Participants With Chronic Hepatitis B Virus Infection
Gilead Sciences
NCT02932150
VIR-2218 and Peginterferon Alfa-2a for Chronic Hepatitis B
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT06092333
Intrahepatic and Peripheral Responses to Imdusiran (AB-729) in Chronic Hepatitis B
University of Maryland, Baltimore
NCT06154278
TLR-9 Adjuvanted Vaccination for Chronic Hepatitis B
University of Maryland, Baltimore
NCT04843852
Study of Bepirovirsen in Nucleos(t)Ide Analogue-treated Participants With Chronic Hepatitis B (B-Well 1)
GlaxoSmithKline
NCT05630807
Study of Bepirovirsen in Nucleos(t)Ide Analogue-treated Participants With Chronic Hepatitis B (B-Well 2)
GlaxoSmithKline
NCT05630820
Study to Evaluate the Antiviral Efficacy, Safety and Tolerability of Tenofovir Disoproxil Fumarate Versus Placebo in Pediatric Participants With Chronic Hepatitis B Infection
Gilead Sciences
NCT01651403
Efficacy & Safety of Tenofovir Disoproxil Fumarate (TDF) Plus Peginterferon α-2a (Peg-IFN) Versus TDF or Peg-IFN Monotherapy in Chronic Hepatitis B
Gilead Sciences
NCT01277601
Study to Evaluate Efficacy and Safety of Switching From TDF to TAF in Adults With Chronic Hepatitis B Who Are Virologically Suppressed
Gilead Sciences
NCT02979613
Safety and Efficacy of GS-4774 in Combination With Tenofovir Disoproxil Fumarate (TDF) for the Treatment of Participants With Chronic Hepatitis B (CHB) and Who Are Currently Not on Treatment
Gilead Sciences
NCT02174276
Study to Evaluate the Safety, Tolerability, and Efficacy of Vesatolimod in Combination With Tenofovir Disoproxil Fumarate (TDF) in Adults With Chronic Hepatitis B (CHB) Infection Who Are Currently Not Being Treated
Gilead Sciences
NCT02579382
Study To Evaluate Safety and Efficacy of Vesatolimod for the Treatment of Chronic Hepatitis B Virus in Virally-Suppressed Participants
Gilead Sciences
NCT02166047
Evaluation of Chronic HBV Patients w/Evidence of HBV Replication and Normal or Minimally Elevated Liver Transaminases.
Gilead Sciences
NCT00263614
A Study Evaluating AHB-137 in Healthy Participants and Participants with Chronic Hepatitis B
AusperBio Therapeutics
NCT05717686
Add-on Peginterferon Following Nucleos(t)Ide Analogue Treatment
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT02364336
A Phase III Study of Entecavir vs Lamivudine in Chronic Hepatitis B Subjects With Incomplete Response to Lamivudine
Bristol-Myers Squibb
NCT00036608
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 7 |
| Phase 3 | 5 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Chronic Hepatitis B records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Chronic Hepatitis B trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Chronic Hepatitis B page
16 registered trials, 4 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 4 Chronic Hepatitis B trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Gilead Sciences sponsors the most Chronic Hepatitis B trials on record, review their full trial history before evaluating a specific study. See Gilead Sciences's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Chronic Hepatitis B condition card totals 16 registered trials; most-linked intervention Placebo; top US site state Maryland. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.