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ACTIVE NOT RECRUITING Phase 2

Abiraterone Acetate and Antiandrogen Therapy With or Without Cabazitaxel and Prednisone in Treating Patients With Metastatic, Castration-Resistant Prostate Cancer Previously Treated With Docetaxel

NCT03419234 · View on ClinicalTrials.gov ↗

Study Summary

This randomized phase II trial studies how well abiraterone acetate and antiandrogen therapy, with or without cabazitaxel and prednisone, work in treating patients with castration-resistant prostate cancer previously treated with docetaxel that has spread to other parts of the body. Androgens can cause the growth of prostate cancer cells. Hormone therapy using abiraterone acetate and antiandrogen therapy may fight prostate cancer by lowering and/or blocking the use of androgens by the tumor cells. Drugs used in chemotherapy, such as cabazitaxel and prednisone, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving abiraterone acetate and antiandrogen therapy with or without cabazitaxel and prednisone may help kill more tumor cells.

Interventions

  • DRUG Prednisone
  • DRUG Abiraterone Acetate
  • DRUG Cabazitaxel
  • DRUG Androgen deprivation therapy

Study Locations (20)

California

  • Kaiser Permanente-Deer Valley Medical Center — Antioch
  • PCR Oncology — Arroyo Grande
  • Sutter Auburn Faith Hospital — Auburn
  • Sutter Cancer Centers Radiation Oncology Services-Auburn — Auburn
  • Alta Bates Summit Medical Center-Herrick Campus — Berkeley
  • Mills-Peninsula Medical Center — Burlingame
  • Sutter Cancer Centers Radiation Oncology Services-Cameron Park — Cameron Park
  • Eden Hospital Medical Center — Castro Valley
  • Adventist Health Cancer Care Center Chico — Chico
  • Sutter Davis Hospital — Davis
  • Epic Care-Dublin — Dublin
  • Kaiser Permanente Dublin — Dublin
  • Bay Area Breast Surgeons Inc — Emeryville

Arkansas

  • Mercy Hospital Fort Smith — Fort Smith
  • CHI Saint Vincent Cancer Center Hot Springs — Hot Springs
  • Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro — Jonesboro
  • John L McClellan Memorial Veterans Hospital — Little Rock

Arizona

  • CTCA at Western Regional Medical Center — Goodyear
  • Kingman Regional Medical Center — Kingman

Alaska

  • Fairbanks Memorial Hospital — Fairbanks

Trial Details

FieldValue
Enrollment Target 223 participants
Start Date 2018-04-26
Est. Completion 2026-04-01
Phase Phase 2

Sponsor

ECOG-ACRIN Cancer Research Group

52 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03419234

The ClinicalTrials.gov registry entry for NCT03419234 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 223 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is ECOG-ACRIN Cancer Research Group, which has 52 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 5 conditions, with Castration-Resistant Prostate Carcinoma appearing as the primary indexed condition, and to 4 interventions — of which Prednisone is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03419234 reports 20 study locations spanning 4 distinct geographic areas — top geographies include California, Arkansas, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03419234 about?

NCT03419234 is a clinical study titled "Abiraterone Acetate and Antiandrogen Therapy With or Without Cabazitaxel and Prednisone in Treating Patients With Metastatic, Castration-Resistant Prostate Cancer Previously Treated With Docetaxel". This randomized phase II trial studies how well abiraterone acetate and antiandrogen therapy, with or without cabazitaxel and prednisone, work in treating patients with castration-resistant prostate cancer previously treated with docetaxel that has spread to other parts of the body. Androgens can ca...

What is the current status of trial NCT03419234?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 223 participants. The study started on 2018-04-26. Estimated completion is 2026-04-01.

What conditions does trial NCT03419234 study?

This clinical trial studies the following conditions: Castration-Resistant Prostate Carcinoma, Stage IV Prostate Adenocarcinoma AJCC v7, Prostate Carcinoma Metastatic in the Bone, Castration Levels of Testosterone, Metastatic Prostate Carcinoma in the Soft Tissue. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03419234?

The interventions under investigation include: Prednisone (DRUG), Abiraterone Acetate (DRUG), Cabazitaxel (DRUG), Androgen deprivation therapy (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03419234?

This trial is sponsored by ECOG-ACRIN Cancer Research Group, which has 52 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03419234 being conducted?

This trial has 20 study locations across Alaska, Arizona, Arkansas, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial