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ClinicalTrials.gov 17 recruiting now official registry

B-cell Acute Lymphoblastic Leukemia clinical trials

17 of 22 indexed B-cell Acute Lymphoblastic Leukemia trials are currently recruiting.

22 US clinical trials · 17 currently recruiting

B-cell Acute Lymphoblastic Leukemia is the subject of 22 registered US clinical trials on ClinicalTrials.gov, 17 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 20 in Phase 1-2 (earlier-stage). The most active sponsor is University of Colorado, Denver, running 2 of these trials.

The research picture

B-cell Acute Lymphoblastic Leukemia has 22 registered US clinical trials, 17 of them open to new participants right now, about 77% of the total.

17
recruiting participants now
77%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
2
top sponsor: University of Colorado, Denver
Phase 114Phase 26Phase 31

Active & Recent Trials

22 total, page 1 of 1

RECRUITING 300 participants

A Multi-site Study to Evaluate the Persistence of Protective Immunity to Routine Childhood Vaccinations in Participants With B-ALL/Ly Who Have Received Blinatumomab

Arkansas Children's Hospital Research Institute

NCT07422337

RECRUITING Phase 2 240 participants

Caloric Restriction and Activity to Reduce Chemoresistance in B-ALL

Etan Orgel

NCT05082519

RECRUITING Phase 1 135 participants

Dose-escalation and Dose-expansion Study of Safety of Azer-cel (PBCAR0191) in Participants With Relapsed/Refractory (r/r) Non-Hodgkin Lymphoma (NHL) and r/r B-cell Acute Lymphoblastic Leukemia (B-ALL)

Imugene Limited

NCT03666000

RECRUITING Phase 3 130 participants

A Study of Fludarabine Dosing in Children and Young Adults With B-cell Acute Lymphoblastic Leukemia

Memorial Sloan Kettering Cancer Center

NCT07223021

RECRUITING Phase 2 95 participants

The EndRAD Trial: Eliminating Total Body Irradiation (TBI) for NGS-MRD Negative Children, Adolescents, and Young Adults With B-ALL

Pediatric Transplantation & Cellular Therapy Consortium

NCT03509961

RECRUITING Phase 1 93 participants

Co-administration of CART22-65s and huCART19 for B-ALL

Stephan Grupp MD PhD

NCT05674175

RECRUITING Phase 1 90 participants

Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)

Merck Sharp & Dohme

NCT06395103

RECRUITING Phase 2 60 participants

A Phase 2 Study to Assess the Safety and Efficacy of Subcutaneous Blinatumomab in Combination With Low Intensity Chemotherapy in Older Patients With Newly Diagnosed B-cell Acute Lymphoblastic Leukemia

M.D. Anderson Cancer Center

NCT07153796

RECRUITING Phase 1 54 participants

Evaluating the Safety and Efficacy of DuoCAR20.19.22-D95 in Adult Patients With Relapsed or Refractory B-cell Malignancies

University of Kansas Medical Center

NCT06879340

RECRUITING Phase 1 53 participants

CD19x22 Chimeric Antigen Receptor T-cell Therapy (CAR T) in Pediatric B-ALL

University of Colorado, Denver

NCT06559189

RECRUITING Phase 1 52 participants

Phase 1/2 Study of UCART22 in Patients With Relapsed or Refractory CD22+ B-cell Acute Lymphoblastic Leukemia (BALLI-01)

Cellectis S.A.

NCT04150497

RECRUITING Phase 1 45 participants

UCD19 CarT in Treatment of Pediatric B-ALL and B-NHL

University of Colorado, Denver

NCT04544592

RECRUITING Phase 1 40 participants

ABL001 + Dasatinib + Prednisone + Blinatumomab in BCR-ABL+ B-ALL or CML

Marlise Luskin, MD

NCT03595917

RECRUITING Phase 1 36 participants

Study of VIP943 in Subjects With Advanced CD123+ Hematologic Malignancies

Vincerx Pharma

NCT06034275

RECRUITING Phase 1 32 participants

Gene Therapy for CD19-Positive Hematologic Malignancies (SENTRY-CD19)

Vironexis Biotherapeutics

NCT06533579

RECRUITING Phase 1 28 participants

Study of Inotuzumab Ozogamicin, Venetoclax, and Dexamethasone for Relapsed B-cell ALL

Children's Hospital Medical Center, Cincinnati

NCT06863259

RECRUITING Phase 2 25 participants

Blinatumomab After TCR Alpha Beta/CD19 Depleted HCT

Medical College of Wisconsin

NCT04746209

ACTIVE NOT RECRUITING Phase 1 150 participants

NKX019, Intravenous Allogeneic Chimeric Antigen Receptor Natural Killer Cells (CAR NK), in Adults With B-cell Cancers

Nkarta

NCT05020678

ACTIVE NOT RECRUITING Phase 2 121 participants

Study of Efficacy and Safety of Tisagenlecleucel in HR B-ALL EOC MRD Positive Patients

Novartis Pharmaceuticals

NCT03876769

ACTIVE NOT RECRUITING Phase 1 36 participants

Phase I Study of Inotuzumab With Augmented BFM Re-Induction for Patients With Relapsed/Refractory B-cell ALL

University of Virginia

NCT03962465

ACTIVE NOT RECRUITING Phase 2 30 participants

A Second Infusion (Early Reinfusion) of Tisagenlecleucel in Children and Young Adults With B-Cell Acute Lymphoblastic Leukemia(B-ALL)

Memorial Sloan Kettering Cancer Center

NCT05460533

ACTIVE NOT RECRUITING Phase 1 23 participants

Venetoclax Plus Inotuzumab for B-ALL

Dana-Farber Cancer Institute

NCT05016947

Phase Distribution

PhaseTrial count
Phase 1 14
Phase 2 6
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the B-cell Acute Lymphoblastic Leukemia Trial Landscape

22 indexed B-cell Acute Lymphoblastic Leukemia studies · 17 recruiting (77%).

Phase mix: 1 late (III/IV) vs 20 early (I/II).

Top sponsor: University of Colorado, Denver (2 trials), 9 others listed. 22 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for B-cell Acute Lymphoblastic Leukemia?

PlainTrial tracks 22 US clinical trials for B-cell Acute Lymphoblastic Leukemia, of which 17 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for B-cell Acute Lymphoblastic Leukemia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.