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NCT04544592 · ClinicalTrials.gov registry record · Phase 1
UCD19 CarT in Treatment of Pediatric B-ALL and B-NHL
A Phase 1 study of B-Cell Non-Hodgkin Lymphoma and B-cell Acute Lymphoblastic Leukemia, sponsored by University of Colorado, Denver.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 45
- Enrollment target
- 1
- Study location
NCT04544592 is a Phase 1 study of B-Cell Non-Hodgkin Lymphoma and B-cell Acute Lymphoblastic Leukemia that is actively recruiting participants, run by University of Colorado, Denver. The registered enrollment target is 45 participants, below the 128-participant average among 24 other B-Cell Non-Hodgkin Lymphoma trials with a reported enrollment target (65% lower). The trial reports 1 study location across 1 state.
The verdict
NCT04544592, a Phase 1 study of B-Cell Non-Hodgkin Lymphoma and B-cell Acute Lymphoblastic Leukemia, is actively recruiting participants, sponsored by University of Colorado, Denver.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 45 participants
- Enrollment target
- 1
- Study location
Study Summary
This phase I/II trial will investigate a new CD19 directed CAR-T therapy manufactured locally with the goals to expedite infusion to wider patient inclusion that includes those who were previously excluded, such as pediatric patients with B-cell NHL and patients in primary relapse.
Conditions Studied
Interventions
- DRUG CD19CAR-CD3Zeta-4-1BB-Expressing Autologous T-Lymphocyte Cells
Study Locations (1)
Colorado
- Children's Hospital Colorado - Aurora
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 45 participants |
| Start Date | 2021-03-10 |
| Est. Completion | 2026-07 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04544592
The ClinicalTrials.gov registry entry for NCT04544592 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 45 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 128-participant average among 24 other B-Cell Non-Hodgkin Lymphoma trials with a reported enrollment target (65% lower). The listed sponsor is University of Colorado, Denver, which has 1,283 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with B-Cell Non-Hodgkin Lymphoma appearing as the primary indexed condition, and to 1 intervention - of which CD19CAR-CD3Zeta-4-1BB-Expressing Autologous T-Lymphocyte Cells is the first listed.
NCT04544592 reports 1 study location spanning 1 distinct geographic area - top geographies include Colorado.
Frequently Asked Questions
What is clinical trial NCT04544592 about?
NCT04544592 is a clinical study titled "UCD19 CarT in Treatment of Pediatric B-ALL and B-NHL". This phase I/II trial will investigate a new CD19 directed CAR-T therapy manufactured locally with the goals to expedite infusion to wider patient inclusion that includes those who were previously excluded, such as pediatric patients with B-cell NHL and patients in primary relapse.
What is the current status of trial NCT04544592?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 45 participants. The study started on 2021-03-10. Estimated completion is 2026-07.
What conditions does trial NCT04544592 study?
This clinical trial studies the following conditions: B-Cell Non-Hodgkin Lymphoma, B-cell Acute Lymphoblastic Leukemia.
What interventions are being tested in trial NCT04544592?
The interventions under investigation include: CD19CAR-CD3Zeta-4-1BB-Expressing Autologous T-Lymphocyte Cells (DRUG).
Who is sponsoring clinical trial NCT04544592?
This trial is sponsored by University of Colorado, Denver, which has 1,283 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04544592 being conducted?
This trial has 1 study location across Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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