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NCT06879340 · ClinicalTrials.gov registry record · Phase 1
Evaluating the Safety and Efficacy of DuoCAR20.19.22-D95 in Adult Patients With Relapsed or Refractory B-cell Malignancies
A Phase 1 study of B-Cell Non-Hodgkin Lymphoma and B-cell Acute Lymphoblastic Leukemia, sponsored by University of Kansas Medical Center.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 54
- Enrollment target
- 1
- Study location
NCT06879340: Recruiting Phase 1 study of B-Cell Non-Hodgkin Lymphoma and B-cell Acute Lymphoblastic Leukemia, sponsored by University of Kansas Medical Center.
NCT06879340 is a Phase 1 study of B-Cell Non-Hodgkin Lymphoma and B-cell Acute Lymphoblastic Leukemia that is actively recruiting participants, run by University of Kansas Medical Center. The registered enrollment target is 54 participants, below the 127-participant average among 24 other B-Cell Non-Hodgkin Lymphoma trials with a reported enrollment target (57% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06879340, a Phase 1 study of B-Cell Non-Hodgkin Lymphoma and B-cell Acute Lymphoblastic Leukemia, is actively recruiting participants, sponsored by University of Kansas Medical Center.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 54 participants
- Enrollment target
- 1
- Study location
Study Summary
This multicenter phase 1 trial with "3 + 3" dose escalation design seeks to examine the feasibility and safety of the administration of autologous T cells that have been modified through the introduction of chimeric antigen receptors targeting the B cell surface antigens CD19/20/22 following administration of a chemotherapy lymphodepletion regimen in adults with relapsed/refractory B-cell acute lymphoblastic leukemia (ALL) or Non-Hodgkin's lymphoma (NHL). The overall goals of this study are to estimate maximum tolerated dose (MTD) level, establish the overall safety profile and evaluate initial efficacy of administering duo-CAR-T cell treatment in this patient population.
Primary Outcome
The MTD is defined as the dose level immediately below that in which ≥ 2/6 participants experience a dose limiting toxicity (DLT).
Conditions Studied
Interventions
- DRUG DuoCAR20.19.22-D95
- DRUG Fludarabine (Conditional therapy)
- DRUG Cyclophosphamide (Conditional therapy)
Study Locations (1)
Kansas
- University of Kansas Cancer Center - Westwood
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 54 participants |
| Start Date | 2025-03-31 |
| Est. Completion | 2040-03 |
| Phase | Phase 1 |
What NCT06879340 shows while recruiting
NCT06879340 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 54 participants, a relatively small participant target, below the 127-participant average among 24 other B-Cell Non-Hodgkin Lymphoma trials with a reported enrollment target (57% lower).
The record links to 2 conditions, with B-Cell Non-Hodgkin Lymphoma appearing as the primary indexed condition, and to 3 interventions - of which DuoCAR20.19.22-D95 is the first listed.
NCT06879340 reports a single indexed study location in Kansas.
Frequently Asked Questions
What is clinical trial NCT06879340 about?
NCT06879340 is a clinical study titled "Evaluating the Safety and Efficacy of DuoCAR20.19.22-D95 in Adult Patients With Relapsed or Refractory B-cell Malignancies". This multicenter phase 1 trial with "3 + 3" dose escalation design seeks to examine the feasibility and safety of the administration of autologous T cells that have been modified through the introduction of chimeric antigen receptors targeting the B cell surface antigens CD19/20/22 following adminis...
What is the current status of trial NCT06879340?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 54 participants. The study started on 2025-03-31. Estimated completion is 2040-03.
What conditions does trial NCT06879340 study?
This clinical trial studies the following conditions: B-Cell Non-Hodgkin Lymphoma, B-cell Acute Lymphoblastic Leukemia.
What interventions are being tested in trial NCT06879340?
The interventions under investigation include: DuoCAR20.19.22-D95 (DRUG), Fludarabine (Conditional therapy) (DRUG), Cyclophosphamide (Conditional therapy) (DRUG).
Who is sponsoring clinical trial NCT06879340?
This trial is sponsored by University of Kansas Medical Center, which has 408 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06879340 being conducted?
This trial has 1 study location across Kansas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for B-Cell Non-Hodgkin Lymphoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06879340's enrollment target sits among peer trials
54 14th of 24 higher than 11 of 24 other B-Cell Non-Hodgkin Lymphoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other B-Cell Non-Hodgkin Lymphoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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