Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04742894 · ClinicalTrials.gov registry record · NA
Neural Bases of Vocal Sensorimotor Impairment in Aphasia
A NA study of Aphasia, sponsored by The University of Texas at Dallas.
- Recruiting
- Registry status
- NA
- Development phase
- 100
- Enrollment target
- 3
- Study locations
NCT04742894: Recruiting NA study of Aphasia, sponsored by The University of Texas at Dallas.
NCT04742894 is a NA study of Aphasia that is actively recruiting participants, run by The University of Texas at Dallas. The registered enrollment target is 100 participants, above the 81-participant average among 42 other Aphasia trials with a reported enrollment target (23% higher). The trial reports 3 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04742894, a NA study of Aphasia, is actively recruiting participants, sponsored by The University of Texas at Dallas.
- RECRUITING
- Registry status
- NA
- Development phase
- 100 participants
- Enrollment target
- 3
- Study locations
Study Summary
Aphasia is the most common type of post-stroke communication disorder characterized by deficits in speech comprehension, production and control. While recovery can be promoted with speech therapy, improvement remains modest and typically requires a large number of sessions contributing to rising health care costs. Traditional aphasia therapy focus on enhancing speech motor output; however, recent evidence suggests that the auditory feedback also plays a critical role in fluent speech. Therefore, a key step toward refining treatment strategies is to develop objective biomarkers that can probe the integrity of sensorimotor mechanisms of speech auditory feedback and identify their impaired function in patients with post-stroke aphasia. This study aims to examine the behavioral, neurophysiological (EEG), and neuroimaging (fMRI) biomarkers of speech impairment following stroke with focus on understanding the role of auditory feedback for speech production and control. We plan to test individuals with post-stroke aphasia and a matched neuroptypical control group during different speech production tasks under the altered auditory feedback paradigm. In addition, we aim to examine the effect of audio-visual feedback training on enhancing communication ability during speech. These biomarkers will be combined with existing lesion-symptom-mapping data in the aphasic group in order to identify the patterns of brain damage and diminished structural connectivity within the auditory-motor areas of the left hemisphere that predict impaired sensorimotor processing of speech in aphasia. The long-term goal of this research is to develop a model for identifying the source of sensorimotor deficit and improve diagnosis and targeted treatment of speech disorders in aphasia.
Primary Outcome
Participants accuracy in using their speech for controlling the visual cursor will be assessed via measuring their deviation from hitting a pre-defined target on the screen.
Conditions Studied
Interventions
- BEHAVIORAL Visual Feedback Training
Study Locations (3)
California
- University of California Irvine - Irvine
South Carolina
- University of South Carolina - Columbia
Texas
- The University of Texas at Dallas - Richardson
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2021-07-11 |
| Est. Completion | 2026-02-28 |
| Phase | NA |
What NCT04742894 shows while recruiting
NCT04742894 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, above the 81-participant average among 42 other Aphasia trials with a reported enrollment target (23% higher).
The record links to 1 condition, with Aphasia appearing as the primary indexed condition, and to 1 intervention - of which Visual Feedback Training is the first listed.
NCT04742894 reports a single indexed study location in California, South Carolina, Texas.
Frequently Asked Questions
What is clinical trial NCT04742894 about?
NCT04742894 is a clinical study titled "Neural Bases of Vocal Sensorimotor Impairment in Aphasia". Aphasia is the most common type of post-stroke communication disorder characterized by deficits in speech comprehension, production and control. While recovery can be promoted with speech therapy, improvement remains modest and typically requires a large number of sessions contributing to rising hea...
What is the current status of trial NCT04742894?
This trial is currently recruiting. It is a NA study. The enrollment target is 100 participants. The study started on 2021-07-11. Estimated completion is 2026-02-28.
What conditions does trial NCT04742894 study?
This clinical trial studies the following conditions: Aphasia.
What interventions are being tested in trial NCT04742894?
The interventions under investigation include: Visual Feedback Training (BEHAVIORAL).
Who is sponsoring clinical trial NCT04742894?
This trial is sponsored by The University of Texas at Dallas, which has 50 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04742894 being conducted?
This trial has 3 study locations across California, South Carolina, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Aphasia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04742894's enrollment target sits among peer trials
100 13th of 42 higher than 29 of 42 other Aphasia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Aphasia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Transcranial Direct Current Stimulation (tDCS) With Verb Network Strengthening Treatment (VNeST) in Chronic Aphasia
RECRUITING · NA
-
Transcranial Alternating Current Stimulation (tACS) in Aphasia
RECRUITING · NA
-
tACS to Enhance Language Abilities
RECRUITING · NA
-
Treatment Outcomes With tDCS in Post-Stroke Aphasia
RECRUITING · NA
-
Telerehabilitation for Aphasia (TERRA)
RECRUITING · NA
-
Combined Exercise and Targeted Therapy for Post-Stroke Reading Deficits
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01048281 · 100 participants
Clinical & Pathological Studies of Upper Gastrointestinal Carcinoma
- NCT01161199 · 100 participants
The Use of Leukapheresis to Support HIV Pathogenesis Studies
- NCT01327690 · 100 participants · Early Phase 1
Mental Health in Veterans and Families After Group Therapies
- NCT01730781 · 100 participants
Imaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI